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Article: The cystic fibrosis gene and resting energy expenditure

TitleThe cystic fibrosis gene and resting energy expenditure
Authors
Issue Date1991
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/jpeds
Citation
Journal Of Pediatrics, 1991, v. 119 n. 6, p. 913-916 How to Cite?
AbstractTo determine whether the increase in resting energy expenditure in cystic fibrosis is associated with the primary genetic defect (ΔF508) or with declining pulmonary function, or both, we tested resting every energy expenditure prospectively in 32 male subjects (aged 7 to 39 years) who were normally nourished and had good pulmonary function. They were categorized into three genotype groups on the basis of the presence or absence of ΔF508 and pancreatic function. Mean resting energy expenditure was 104% of the predicted value and was not associated with genotype. When 29 subjects with normal nutritional status but variable lung function were added to the group, there was a strong correlation between declining pulmonary function and increased resting energy expenditure. We conclude that increased resting energy expenditure in normally nourished boys and men with cystic fibrosis appears to be more closely associated with declining pulmonary function than with genotype.
Persistent Identifierhttp://hdl.handle.net/10722/44247
ISSN
2015 Impact Factor: 3.89
2015 SCImago Journal Rankings: 1.849
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFried, MDen_HK
dc.contributor.authorDurie, PRen_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorCorey, Men_HK
dc.contributor.authorLevison, Hen_HK
dc.contributor.authorPencharz, PBen_HK
dc.date.accessioned2007-09-12T03:49:50Z-
dc.date.available2007-09-12T03:49:50Z-
dc.date.issued1991en_HK
dc.identifier.citationJournal Of Pediatrics, 1991, v. 119 n. 6, p. 913-916en_HK
dc.identifier.issn0022-3476en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44247-
dc.description.abstractTo determine whether the increase in resting energy expenditure in cystic fibrosis is associated with the primary genetic defect (ΔF508) or with declining pulmonary function, or both, we tested resting every energy expenditure prospectively in 32 male subjects (aged 7 to 39 years) who were normally nourished and had good pulmonary function. They were categorized into three genotype groups on the basis of the presence or absence of ΔF508 and pancreatic function. Mean resting energy expenditure was 104% of the predicted value and was not associated with genotype. When 29 subjects with normal nutritional status but variable lung function were added to the group, there was a strong correlation between declining pulmonary function and increased resting energy expenditure. We conclude that increased resting energy expenditure in normally nourished boys and men with cystic fibrosis appears to be more closely associated with declining pulmonary function than with genotype.en_HK
dc.languageengen_HK
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/jpedsen_HK
dc.relation.ispartofJournal of Pediatricsen_HK
dc.subject.meshCystic Fibrosis - genetics - metabolism - physiopathologyen_HK
dc.subject.meshEnergy Metabolism - geneticsen_HK
dc.subject.meshForced Expiratory Volumeen_HK
dc.subject.meshNutritional Statusen_HK
dc.subject.meshCalorimetryen_HK
dc.titleThe cystic fibrosis gene and resting energy expenditureen_HK
dc.typeArticleen_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_subscribed_fulltexten_HK
dc.identifier.doi10.1016/S0022-3476(05)83042-2en_HK
dc.identifier.pmid1960606-
dc.identifier.scopuseid_2-s2.0-0025720681en_HK
dc.identifier.volume119en_HK
dc.identifier.issue6en_HK
dc.identifier.spage913en_HK
dc.identifier.epage916en_HK
dc.identifier.isiWOS:A1991GV18500011-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridFried, MD=36724734100en_HK
dc.identifier.scopusauthoridDurie, PR=7005360997en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridCorey, M=7005819978en_HK
dc.identifier.scopusauthoridLevison, H=7103193312en_HK
dc.identifier.scopusauthoridPencharz, PB=7102429571en_HK

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