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Article: Identification of the cystic fibrosis gene: Cloning and characterization of complementary DNA

TitleIdentification of the cystic fibrosis gene: Cloning and characterization of complementary DNA
Authors
Issue Date1989
PublisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org
Citation
Science, 1989, v. 245 n. 4922, p. 1066-1073 How to Cite?
AbstractOverlapping complementary DNA clones were isolated from epithelial cell libraries with a genomic DNA segment containing a portion of the putative cystic fibrosis (CF) locus, which is on chromosome 7. Transcripts, approximately 6500 nucleotides in size, were detected in the tissues affected in patients with CF. The predicted protein consists of two similar motifs, each with (i) a domain having properties consistent with membrane association and (ii) a domain believed to be involved in ATP (adenosine triphosphate) binding. A deletion of three base pairs that results in the omission of a phenylalanine residue at the center of the first predicted nucleotide-binding domain was detected in CF patients.
Persistent Identifierhttp://hdl.handle.net/10722/44235
ISSN
2014 Impact Factor: 33.611
2014 SCImago Journal Rankings: 10.107
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRiordan, JRen_HK
dc.contributor.authorRommens, JMen_HK
dc.contributor.authorKerem, BSen_HK
dc.contributor.authorAlon, Nen_HK
dc.contributor.authorRozmahel, Ren_HK
dc.contributor.authorGrzelczak, Zen_HK
dc.contributor.authorZielinski, Jen_HK
dc.contributor.authorLok, Sen_HK
dc.contributor.authorPlavsic, Nen_HK
dc.contributor.authorChou, JLen_HK
dc.contributor.authorDrumm, MLen_HK
dc.contributor.authorIannuzzi, MCen_HK
dc.contributor.authorCollins, FSen_HK
dc.contributor.authorTsui, LCen_HK
dc.date.accessioned2007-09-12T03:49:35Z-
dc.date.available2007-09-12T03:49:35Z-
dc.date.issued1989en_HK
dc.identifier.citationScience, 1989, v. 245 n. 4922, p. 1066-1073en_HK
dc.identifier.issn0036-8075en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44235-
dc.description.abstractOverlapping complementary DNA clones were isolated from epithelial cell libraries with a genomic DNA segment containing a portion of the putative cystic fibrosis (CF) locus, which is on chromosome 7. Transcripts, approximately 6500 nucleotides in size, were detected in the tissues affected in patients with CF. The predicted protein consists of two similar motifs, each with (i) a domain having properties consistent with membrane association and (ii) a domain believed to be involved in ATP (adenosine triphosphate) binding. A deletion of three base pairs that results in the omission of a phenylalanine residue at the center of the first predicted nucleotide-binding domain was detected in CF patients.en_HK
dc.languageengen_HK
dc.publisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.orgen_HK
dc.relation.ispartofScienceen_HK
dc.rightsScience. Copyright © American Association for the Advancement of Science.en_HK
dc.subject.meshAmino acid sequenceen_HK
dc.subject.meshBiological transporten_HK
dc.subject.meshCloning, molecular - methodsen_HK
dc.subject.meshCystic fibrosis - genetics - metabolism - pathologyen_HK
dc.subject.meshCystic fibrosis transmembrane conductance regulatoren_HK
dc.titleIdentification of the cystic fibrosis gene: Cloning and characterization of complementary DNAen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0036-8075&volume=245&issue=4922&spage=1066&epage=1073&date=1989&atitle=Identification+of+the+cystic+fibrosis+gene:+cloning+and+characterization+of+complementary+DNAen_HK
dc.identifier.emailLok, S: silok@genome.hku.hken_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityLok, S=rp00271en_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.natureabstracten_HK
dc.identifier.doi10.1126/science.2475911-
dc.identifier.pmid2475911en_HK
dc.identifier.scopuseid_2-s2.0-0024424270en_HK
dc.identifier.volume245en_HK
dc.identifier.issue4922en_HK
dc.identifier.spage1066en_HK
dc.identifier.epage1073en_HK
dc.identifier.isiWOS:A1989AN70200026-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridRiordan, JR=7202229758en_HK
dc.identifier.scopusauthoridRommens, JM=7006884140en_HK
dc.identifier.scopusauthoridKerem, BS=35376353800en_HK
dc.identifier.scopusauthoridAlon, N=7102272586en_HK
dc.identifier.scopusauthoridRozmahel, R=6701510561en_HK
dc.identifier.scopusauthoridGrzelczak, Z=6602366698en_HK
dc.identifier.scopusauthoridZielinski, J=7203065105en_HK
dc.identifier.scopusauthoridLok, S=21035019900en_HK
dc.identifier.scopusauthoridPlavsic, N=8314412600en_HK
dc.identifier.scopusauthoridChou, JL=24443879300en_HK
dc.identifier.scopusauthoridDrumm, ML=7006422406en_HK
dc.identifier.scopusauthoridIannuzzi, MC=7006338485en_HK
dc.identifier.scopusauthoridCollins, FS=7403031285en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.citeulike3717390-

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