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Article: The mouse eye lens obsolescence (Elo) mutant: studies on crystallin gene expression and linkage analysis between the mutant locus and the gamma-crystallin genes.

TitleThe mouse eye lens obsolescence (Elo) mutant: studies on crystallin gene expression and linkage analysis between the mutant locus and the gamma-crystallin genes.
Authors
Issue Date1987
PublisherCold Spring Harbor Laboratory Press. The Journal's web site is located at http://genesdev.cshlp.org/
Citation
Genes & Development, 1987, v. 1 n. 7, p. 637-644 How to Cite?
AbstractPrevious studies showed that the mouse Elo (eye lens obsolescence) mutation is located on chromosome 1, at a site near the Len-1 locus, which is defined by a set of polymorphic gamma-crystallin proteins. To investigate further the relationship between Elo and the gamma-crystallins, we have examined the steady-state levels of gamma-crystallin transcripts in normal and mutant eyes and analyzed the linkage relationship between the Elo locus and the gamma-crystallin genes. Our data showed that, while gamma-crystallin mRNA levels are preferentially reduced in the mutant eyes, the mutation does not seem to map within the gamma-crystallin gene cluster. The distance between Elo and the gamma 6 gene (the most proximal gamma-crystallin gene member) is estimated to be 1.4 +/- 0.9 cM, whereas that between gamma 6 and the distantly linked gamma 2 gene is 2.7 +/- 1.3 cM. Our data also suggest the possibility of recombination hot spots with the gamma-crystallin gene cluster.
Persistent Identifierhttp://hdl.handle.net/10722/44225
ISSN
2015 Impact Factor: 10.042
2015 SCImago Journal Rankings: 11.812
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorQuinlan, Pen_HK
dc.contributor.authorOda, Sen_HK
dc.contributor.authorBreitman, MLen_HK
dc.contributor.authorTsui, LCen_HK
dc.date.accessioned2007-09-12T03:49:22Z-
dc.date.available2007-09-12T03:49:22Z-
dc.date.issued1987en_HK
dc.identifier.citationGenes & Development, 1987, v. 1 n. 7, p. 637-644en_HK
dc.identifier.issn0890-9369en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44225-
dc.description.abstractPrevious studies showed that the mouse Elo (eye lens obsolescence) mutation is located on chromosome 1, at a site near the Len-1 locus, which is defined by a set of polymorphic gamma-crystallin proteins. To investigate further the relationship between Elo and the gamma-crystallins, we have examined the steady-state levels of gamma-crystallin transcripts in normal and mutant eyes and analyzed the linkage relationship between the Elo locus and the gamma-crystallin genes. Our data showed that, while gamma-crystallin mRNA levels are preferentially reduced in the mutant eyes, the mutation does not seem to map within the gamma-crystallin gene cluster. The distance between Elo and the gamma 6 gene (the most proximal gamma-crystallin gene member) is estimated to be 1.4 +/- 0.9 cM, whereas that between gamma 6 and the distantly linked gamma 2 gene is 2.7 +/- 1.3 cM. Our data also suggest the possibility of recombination hot spots with the gamma-crystallin gene cluster.en_HK
dc.languageengen_HK
dc.publisherCold Spring Harbor Laboratory Press. The Journal's web site is located at http://genesdev.cshlp.org/en_HK
dc.relation.ispartofGenes & developmenten_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshCrystallins - geneticsen_HK
dc.subject.meshGenesen_HK
dc.subject.meshLens, Crystalline - abnormalitiesen_HK
dc.subject.meshLinkage (Genetics)en_HK
dc.subject.meshMutationen_HK
dc.titleThe mouse eye lens obsolescence (Elo) mutant: studies on crystallin gene expression and linkage analysis between the mutant locus and the gamma-crystallin genes.en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0890-9369&volume=1&issue=7&spage=637&epage=644&date=1987&atitle=The+mouse+eye+lens+obsolescence+(Elo)+mutant:+studies+on+crystallin+gene+expression+and+linkage+analysis+between+the+mutant+locus+and+the+gamma-crystallin+genesen_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1101/gad.1.7.637-
dc.identifier.pmid3428594-
dc.identifier.scopuseid_2-s2.0-0023405816en_HK
dc.identifier.volume1en_HK
dc.identifier.issue7en_HK
dc.identifier.spage637en_HK
dc.identifier.epage644en_HK
dc.identifier.isiWOS:A1987K161900001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridQuinlan, P=7007185610en_HK
dc.identifier.scopusauthoridOda, S=7202872496en_HK
dc.identifier.scopusauthoridBreitman, ML=7005448008en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK

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