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Article: Aging effects of vitamin C on a human lens protein produced in vitro
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TitleAging effects of vitamin C on a human lens protein produced in vitro
 
AuthorsRussell, P1
Garland, D1
Zigler Jr, JS1
Meakin, SO1
Tsui, LC1
Breitman, ML1
 
Issue Date1987
 
PublisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/
 
CitationFaseb Journal, 1987, v. 1 n. 1, p. 32-35 [How to Cite?]
 
AbstractHuman lens γ-crystallin obtained from the expression of a gene construct stably integraged into mouse L cells was incubated with ascorbate in the presence of iron and oxygen. The resulting oxidation of the γ-crystallin led to more acidic species of this protein. These alterations were similar to the changes seen with aging in the human lens. The results suggest that oxidation of lens crystallins may responsible for the changes seen on aging and cataract development and that ascorbate may contribute to these alterations.
 
ISSN0892-6638
2013 Impact Factor: 5.480
 
Other Identifiershttp://www.fasebj.org/cgi/reprint/1/1/32
 
ISI Accession Number IDWOS:A1987J289800007
 
DC FieldValue
dc.contributor.authorRussell, P
 
dc.contributor.authorGarland, D
 
dc.contributor.authorZigler Jr, JS
 
dc.contributor.authorMeakin, SO
 
dc.contributor.authorTsui, LC
 
dc.contributor.authorBreitman, ML
 
dc.date.accessioned2007-09-12T03:49:18Z
 
dc.date.available2007-09-12T03:49:18Z
 
dc.date.issued1987
 
dc.description.abstractHuman lens γ-crystallin obtained from the expression of a gene construct stably integraged into mouse L cells was incubated with ascorbate in the presence of iron and oxygen. The resulting oxidation of the γ-crystallin led to more acidic species of this protein. These alterations were similar to the changes seen with aging in the human lens. The results suggest that oxidation of lens crystallins may responsible for the changes seen on aging and cataract development and that ascorbate may contribute to these alterations.
 
dc.description.naturepublished_or_final_version
 
dc.identifier.citationFaseb Journal, 1987, v. 1 n. 1, p. 32-35 [How to Cite?]
 
dc.identifier.epage35
 
dc.identifier.isiWOS:A1987J289800007
 
dc.identifier.issn0892-6638
2013 Impact Factor: 5.480
 
dc.identifier.issue1
 
dc.identifierhttp://www.fasebj.org/cgi/reprint/1/1/32
 
dc.identifier.pmid3301496
 
dc.identifier.scopuseid_2-s2.0-0023607180
 
dc.identifier.spage32
 
dc.identifier.urihttp://hdl.handle.net/10722/44222
 
dc.identifier.volume1
 
dc.languageeng
 
dc.publisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofFASEB Journal
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshAging - metabolism
 
dc.subject.meshAscorbic Acid - pharmacology
 
dc.subject.meshCrystallins- metabolism
 
dc.subject.meshElectrophoresis, Polyacrylamide Gel
 
dc.subject.meshImmunologic Techniques
 
dc.titleAging effects of vitamin C on a human lens protein produced in vitro
 
dc.typeArticle
 
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<contributor.author>Tsui, LC</contributor.author>
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Author Affiliations
  1. National Eye Institute