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Article: Aging effects of vitamin C on a human lens protein produced in vitro

TitleAging effects of vitamin C on a human lens protein produced in vitro
Authors
Issue Date1987
PublisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/
Citation
Faseb Journal, 1987, v. 1 n. 1, p. 32-35 How to Cite?
Abstract
Human lens γ-crystallin obtained from the expression of a gene construct stably integraged into mouse L cells was incubated with ascorbate in the presence of iron and oxygen. The resulting oxidation of the γ-crystallin led to more acidic species of this protein. These alterations were similar to the changes seen with aging in the human lens. The results suggest that oxidation of lens crystallins may responsible for the changes seen on aging and cataract development and that ascorbate may contribute to these alterations.
Persistent Identifierhttp://hdl.handle.net/10722/44222
ISSN
2013 Impact Factor: 5.480
Other Identifiers
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRussell, Pen_HK
dc.contributor.authorGarland, Den_HK
dc.contributor.authorZigler Jr, JSen_HK
dc.contributor.authorMeakin, SOen_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorBreitman, MLen_HK
dc.date.accessioned2007-09-12T03:49:18Z-
dc.date.available2007-09-12T03:49:18Z-
dc.date.issued1987en_HK
dc.identifierhttp://www.fasebj.org/cgi/reprint/1/1/32en_HK
dc.identifier.citationFaseb Journal, 1987, v. 1 n. 1, p. 32-35en_HK
dc.identifier.issn0892-6638en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44222-
dc.description.abstractHuman lens γ-crystallin obtained from the expression of a gene construct stably integraged into mouse L cells was incubated with ascorbate in the presence of iron and oxygen. The resulting oxidation of the γ-crystallin led to more acidic species of this protein. These alterations were similar to the changes seen with aging in the human lens. The results suggest that oxidation of lens crystallins may responsible for the changes seen on aging and cataract development and that ascorbate may contribute to these alterations.en_HK
dc.languageengen_HK
dc.publisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/en_HK
dc.relation.ispartofFASEB Journalen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAging - metabolismen_HK
dc.subject.meshAscorbic Acid - pharmacologyen_HK
dc.subject.meshCrystallins- metabolismen_HK
dc.subject.meshElectrophoresis, Polyacrylamide Gelen_HK
dc.subject.meshImmunologic Techniquesen_HK
dc.titleAging effects of vitamin C on a human lens protein produced in vitroen_HK
dc.typeArticleen_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid3301496en_HK
dc.identifier.scopuseid_2-s2.0-0023607180en_HK
dc.identifier.volume1en_HK
dc.identifier.issue1en_HK
dc.identifier.spage32en_HK
dc.identifier.epage35en_HK
dc.identifier.isiWOS:A1987J289800007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridRussell, P=7401844544en_HK
dc.identifier.scopusauthoridGarland, D=7006362711en_HK
dc.identifier.scopusauthoridZigler Jr, JS=24300314300en_HK
dc.identifier.scopusauthoridMeakin, SO=7006735265en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridBreitman, ML=7005448008en_HK

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