Article: Aging effects of vitamin C on a human lens protein produced in vitro

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TitleAging effects of vitamin C on a human lens protein produced in vitro
AuthorsRussell, P1
Garland, D1
Zigler Jr, JS1
Meakin, SO1
Tsui, LC1
Breitman, ML1
Issue Date1987
PublisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/
CitationFaseb Journal, 1987, v. 1 n. 1, p. 32-35 [How to Cite?]
AbstractHuman lens γ-crystallin obtained from the expression of a gene construct stably integraged into mouse L cells was incubated with ascorbate in the presence of iron and oxygen. The resulting oxidation of the γ-crystallin led to more acidic species of this protein. These alterations were similar to the changes seen with aging in the human lens. The results suggest that oxidation of lens crystallins may responsible for the changes seen on aging and cataract development and that ascorbate may contribute to these alterations.
ISSN0892-6638
2011 Impact Factor: 5.712
2011 SCImago Journal Rankings: 0.680
Other Identifiershttp://www.fasebj.org/cgi/reprint/1/1/32
ISI Accession Number IDWOS:A1987J289800007
DC Field
Value
dc.contributor.authorRussell, P
dc.contributor.authorGarland, D
dc.contributor.authorZigler Jr, JS
dc.contributor.authorMeakin, SO
dc.contributor.authorTsui, LC
dc.contributor.authorBreitman, ML
dc.date.accessioned2007-09-12T03:49:18Z
dc.date.available2007-09-12T03:49:18Z
dc.date.issued1987
dc.description.abstractHuman lens γ-crystallin obtained from the expression of a gene construct stably integraged into mouse L cells was incubated with ascorbate in the presence of iron and oxygen. The resulting oxidation of the γ-crystallin led to more acidic species of this protein. These alterations were similar to the changes seen with aging in the human lens. The results suggest that oxidation of lens crystallins may responsible for the changes seen on aging and cataract development and that ascorbate may contribute to these alterations.
dc.description.naturepublished_or_final_version
dc.identifier.citationFaseb Journal, 1987, v. 1 n. 1, p. 32-35 [How to Cite?]
dc.identifier.epage35
dc.identifier.isiWOS:A1987J289800007
dc.identifier.issn0892-6638
2011 Impact Factor: 5.712
2011 SCImago Journal Rankings: 0.680
dc.identifier.issue1
dc.identifierhttp://www.fasebj.org/cgi/reprint/1/1/32
dc.identifier.pmid3301496
dc.identifier.scopuseid_2-s2.0-0023607180
dc.identifier.spage32
dc.identifier.urihttp://hdl.handle.net/10722/44222
dc.identifier.volume1
dc.languageeng
dc.publisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/
dc.publisher.placeUnited States
dc.relation.ispartofFASEB Journal
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.subject.meshAging - metabolism
dc.subject.meshAscorbic Acid - pharmacology
dc.subject.meshCrystallins- metabolism
dc.subject.meshElectrophoresis, Polyacrylamide Gel
dc.subject.meshImmunologic Techniques
dc.titleAging effects of vitamin C on a human lens protein produced in vitro
dc.typeArticle
Author Affiliations
  1. National Eye Institute