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Article: Differential regulation of γ-crystallin genes during mouse lens development

TitleDifferential regulation of γ-crystallin genes during mouse lens development
Authors
Issue Date1987
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ydbio
Citation
Developmental Biology, 1987, v. 119 n. 1, p. 260-267 How to Cite?
AbstractUsing gene-specific probes derived from four mouse γ-crystallin cDNAs, we have examined the regulation of different members of the mouse γ-crystallin gene family during lens development. Our analysis revealed that, while the different γ-crystallin genes appear to be coordinately activated during embryogenesis, the steady-state levels of their corresponding transcripts are differentially regulated, resulting in variations in the relative abundance of individual species at different stages of development. This complex pattern of gene regulation presumably accounts for one of the mechanisms determining the spatial distribution γ-crystallins within the lens.
Persistent Identifierhttp://hdl.handle.net/10722/44219
ISSN
2015 Impact Factor: 3.155
2015 SCImago Journal Rankings: 2.554
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMurerOrlando, Men_HK
dc.contributor.authorPaterson, RCen_HK
dc.contributor.authorLok, Sen_HK
dc.date.accessioned2007-09-12T03:49:15Z-
dc.date.available2007-09-12T03:49:15Z-
dc.date.issued1987en_HK
dc.identifier.citationDevelopmental Biology, 1987, v. 119 n. 1, p. 260-267en_HK
dc.identifier.issn0012-1606en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44219-
dc.description.abstractUsing gene-specific probes derived from four mouse γ-crystallin cDNAs, we have examined the regulation of different members of the mouse γ-crystallin gene family during lens development. Our analysis revealed that, while the different γ-crystallin genes appear to be coordinately activated during embryogenesis, the steady-state levels of their corresponding transcripts are differentially regulated, resulting in variations in the relative abundance of individual species at different stages of development. This complex pattern of gene regulation presumably accounts for one of the mechanisms determining the spatial distribution γ-crystallins within the lens.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ydbioen_HK
dc.relation.ispartofDevelopmental Biologyen_HK
dc.subject.meshAmino acid sequenceen_HK
dc.subject.meshCrystallins - geneticsen_HK
dc.subject.meshDna - metabolismen_HK
dc.subject.meshEmbryonic and fetal developmenten_HK
dc.subject.meshGenesen_HK
dc.titleDifferential regulation of γ-crystallin genes during mouse lens developmenten_HK
dc.typeArticleen_HK
dc.identifier.emailLok, S: silok@genome.hku.hken_HK
dc.identifier.authorityLok, S=rp00271en_HK
dc.description.naturelink_to_subscribed_fulltexten_HK
dc.identifier.doi10.1016/0012-1606(87)90227-2en_HK
dc.identifier.pmid3792630-
dc.identifier.scopuseid_2-s2.0-0023139661en_HK
dc.identifier.volume119en_HK
dc.identifier.issue1en_HK
dc.identifier.spage260en_HK
dc.identifier.epage267en_HK
dc.identifier.isiWOS:A1987F660900028-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridMurerOrlando, M=6602472036en_HK
dc.identifier.scopusauthoridPaterson, RC=7103355150en_HK
dc.identifier.scopusauthoridLok, S=21035019900en_HK

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