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Article: Assignment to human gamma crystallin multigene family to chromosome 2

TitleAssignment to human gamma crystallin multigene family to chromosome 2
Authors
Issue Date1985
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0740-7750
Citation
Somatic Cell And Molecular Genetics, 1985, v. 11 n. 5, p. 511-516 How to Cite?
Abstract
The multigene family for human γ-crystallin has been assigned to chromosome 2 using rodent-human somatic cell hybrids and filter hybridization analysis of cell hybrid DNA. Two genomic DNA probes containing human γ-crystallin gene sequences hybridize to five fragments in human DNA digested with the restriction enzyme EcoRI. By correlating the presence of these fragments in somatic cell hybrid DNA with the human chromosome content of the hybrids, at least six human γ-crystallin genes can be mapped to chromosome 2. Data obtained with a hybrid clone containing a mouse-human interspecies translocation suggest that these genes may be clustered together on the long arm of human chromosome 2.
Persistent Identifierhttp://hdl.handle.net/10722/44212
ISSN
ISI Accession Number ID

 

Author Affiliations
  1. University of Toronto
  2. Hospital for Sick Children University of Toronto
DC FieldValueLanguage
dc.contributor.authorWillard, HFen_HK
dc.contributor.authorMeakin, SOen_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorBreitman, MLen_HK
dc.date.accessioned2007-09-12T03:49:07Z-
dc.date.available2007-09-12T03:49:07Z-
dc.date.issued1985en_HK
dc.identifier.citationSomatic Cell And Molecular Genetics, 1985, v. 11 n. 5, p. 511-516en_HK
dc.identifier.issn0740-7750en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44212-
dc.description.abstractThe multigene family for human γ-crystallin has been assigned to chromosome 2 using rodent-human somatic cell hybrids and filter hybridization analysis of cell hybrid DNA. Two genomic DNA probes containing human γ-crystallin gene sequences hybridize to five fragments in human DNA digested with the restriction enzyme EcoRI. By correlating the presence of these fragments in somatic cell hybrid DNA with the human chromosome content of the hybrids, at least six human γ-crystallin genes can be mapped to chromosome 2. Data obtained with a hybrid clone containing a mouse-human interspecies translocation suggest that these genes may be clustered together on the long arm of human chromosome 2.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0740-7750en_HK
dc.relation.ispartofSomatic Cell and Molecular Geneticsen_HK
dc.rightsThe original publication is available at www.springerlink.comen_HK
dc.subject.meshChromosome mappingen_HK
dc.subject.meshChromosomes, human, 1-3en_HK
dc.subject.meshCricetinaeen_HK
dc.subject.meshCrystallins - geneticsen_HK
dc.subject.meshDna restriction enzymesen_HK
dc.titleAssignment to human gamma crystallin multigene family to chromosome 2en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0740-7750&volume=11&issue=5&spage=511&epage=516&date=1985&atitle=Assignment+of+the+human+g-crystallin+multigene+family+to+chromosome+2en_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.natureabstracten_HK
dc.identifier.doi10.1007/BF01534846-
dc.identifier.pmid2994242en_HK
dc.identifier.scopuseid_2-s2.0-0022409931en_HK
dc.identifier.volume11en_HK
dc.identifier.issue5en_HK
dc.identifier.spage511en_HK
dc.identifier.epage516en_HK
dc.identifier.isiWOS:A1985ARK8400012-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWillard, HF=7103010013en_HK
dc.identifier.scopusauthoridMeakin, SO=7006735265en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridBreitman, ML=7005448008en_HK

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