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Article: Analysis of the mouse γ-crystallin gene family: Assignment of multiple cDNAs to discrete genomic sequences and characterization of a representative gene

TitleAnalysis of the mouse γ-crystallin gene family: Assignment of multiple cDNAs to discrete genomic sequences and characterization of a representative gene
Authors
Issue Date1984
PublisherOxford University Press. The Journal's web site is located at http://nar.oxfordjournals.org/
Citation
Nucleic Acids Research, 1984, v. 12 n. 11, p. 4517-4529 How to Cite?
AbstractBlot hybridization analysis of mouse DNA with γ-crystallin-specific CDNAs has detected the presence of a multigene family comprised of at least four related genes. The detailed structure of one of these genes, mouse γ 4-crystallin (Mγ 4.1), and its corresponding cDNA has been determined. The gene spans approximately 2.6 kilobases (kb) and contains two introns. The gene predicts a polypeptide of 174 amino acids that shares extensive sequence homology with γ-crystallin polypeptides of other species. The two similar structural domains of the protein correspond exactly to the second and third exons of the gene, supporting an exon-duplication model of gene evolution. The similarity in structure of this gene to that recently reported for a γ-crystallin gene of the rat (1) suggests that a common structure may exist for all γ-crystallin genes of the two species. Moreover, a highly conserved region, 50 nucleotides in length, immediately precedes the TATA box of both the mouse and rat genes, suggesting that this sequence may be important in gene regulation. © 1984 IRL Press Limited.
Persistent Identifierhttp://hdl.handle.net/10722/44207
ISSN
2014 Impact Factor: 9.112
2014 SCImago Journal Rankings: 6.160
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLok, Sen_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorShinohara, Ten_HK
dc.contributor.authorPiatigorsky, Jen_HK
dc.contributor.authorGold, Ren_HK
dc.contributor.authorBreitman, Men_HK
dc.date.accessioned2007-09-12T03:49:00Z-
dc.date.available2007-09-12T03:49:00Z-
dc.date.issued1984en_HK
dc.identifier.citationNucleic Acids Research, 1984, v. 12 n. 11, p. 4517-4529en_HK
dc.identifier.issn0305-1048en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44207-
dc.description.abstractBlot hybridization analysis of mouse DNA with γ-crystallin-specific CDNAs has detected the presence of a multigene family comprised of at least four related genes. The detailed structure of one of these genes, mouse γ 4-crystallin (Mγ 4.1), and its corresponding cDNA has been determined. The gene spans approximately 2.6 kilobases (kb) and contains two introns. The gene predicts a polypeptide of 174 amino acids that shares extensive sequence homology with γ-crystallin polypeptides of other species. The two similar structural domains of the protein correspond exactly to the second and third exons of the gene, supporting an exon-duplication model of gene evolution. The similarity in structure of this gene to that recently reported for a γ-crystallin gene of the rat (1) suggests that a common structure may exist for all γ-crystallin genes of the two species. Moreover, a highly conserved region, 50 nucleotides in length, immediately precedes the TATA box of both the mouse and rat genes, suggesting that this sequence may be important in gene regulation. © 1984 IRL Press Limited.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://nar.oxfordjournals.org/en_HK
dc.relation.ispartofNucleic Acids Researchen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAmino acid sequenceen_HK
dc.subject.meshBacteriophage lambda - geneticsen_HK
dc.subject.meshCloning, molecularen_HK
dc.subject.meshCrystallins - geneticsen_HK
dc.subject.meshDna - analysisen_HK
dc.titleAnalysis of the mouse γ-crystallin gene family: Assignment of multiple cDNAs to discrete genomic sequences and characterization of a representative geneen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0305-1048&volume=12&issue=11&spage=4517&epage=4529&date=1984&atitle=Analysis+of+the+mouse+g-crystallin+gene+family:+Assignment+of+multiple+cDNAs+to+discrete+genomic+sequences+and+characterization+of+a+representative+geneen_HK
dc.identifier.emailLok, S: silok@genome.hku.hken_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityLok, S=rp00271en_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1093/nar/12.11.4517en_HK
dc.identifier.pmid6330674-
dc.identifier.pmcidPMC318855-
dc.identifier.scopuseid_2-s2.0-0021760456en_HK
dc.identifier.volume12en_HK
dc.identifier.issue11en_HK
dc.identifier.spage4517en_HK
dc.identifier.epage4529en_HK
dc.identifier.isiWOS:A1984SW20600008-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLok, S=21035019900en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridShinohara, T=7202958417en_HK
dc.identifier.scopusauthoridPiatigorsky, J=7102833468en_HK
dc.identifier.scopusauthoridGold, R=24514035500en_HK
dc.identifier.scopusauthoridBreitman, M=7005448008en_HK

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