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Article: Prevalence of human papillomavirus types 16 and 18 in penile carcinoma: A study of 41 cases using PCR

TitlePrevalence of human papillomavirus types 16 and 18 in penile carcinoma: A study of 41 cases using PCR
Authors
Issue Date1994
PublisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/
Citation
Journal Of Clinical Pathology, 1994, v. 47 n. 9, p. 823-826 How to Cite?
AbstractAims - To determine retrospectively the prevalence of human papillomavirus (HPV) types 16 and 18 in penile carcinomas. Methods - Forty one surgically resected penile carcinomas from the archives at Queen Mary Hospital, Hong Kong, were reviewed and classified into verrucous carcinoma, and well, moderately, and poorly differentiated squamous cell carcinomas. Paraffin wax embedded tumour tissue was sectioned and analysed for HPV 16 and HPV 18 using the polymerase chain reaction with type specific internal probes. Results - There were seven verrucous carcinomas, and 11 well, 17 moderately, and six poorly differentiated squamous cell carcinomas. Six of the 41 (15%) patients had penile carcinoma containing HPV 16 or HPV 18 DNA, or both, with HPV 16 found in four (10%) and HPV 18 in four (10%). The mean ages of HPV positive and HPV negative groups of patients were 68.5 and 57.6 years, respectively (p < 0.05). None of the seven verrucous and 11 well differentiated squamous cell carcinomas was positive for HPV. The mean age of patients who had these carcinomas was 52.4 years. As a group, these low grade carcinomas occurred in patients younger by more than a decade than those who had carcinomas of the higher grades (mean age 64.4 years; p < 0.01). Conclusions - Penile carcinomas had much lower rates of infection by HPV 16 or HPV 18 than cervical carcinomas in this Hong Kong population. Based on our findings and on data collated from published findings, it is concluded that penile verrucous carcinomas are not associated with HPV 16 and HPV 18, The overall low prevalence of HPV 16 and HPV 18 in penile carcinomas suggests that other HPV types might be important in the pathogenesis of these tumours.
Persistent Identifierhttp://hdl.handle.net/10722/43607
ISSN
2015 Impact Factor: 2.912
2015 SCImago Journal Rankings: 1.260
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, KWen_HK
dc.contributor.authorLam, KYen_HK
dc.contributor.authorChan, ACLen_HK
dc.contributor.authorLau, Pen_HK
dc.contributor.authorSrivastava, Gen_HK
dc.date.accessioned2007-03-23T04:50:12Z-
dc.date.available2007-03-23T04:50:12Z-
dc.date.issued1994en_HK
dc.identifier.citationJournal Of Clinical Pathology, 1994, v. 47 n. 9, p. 823-826en_HK
dc.identifier.issn0021-9746en_HK
dc.identifier.urihttp://hdl.handle.net/10722/43607-
dc.description.abstractAims - To determine retrospectively the prevalence of human papillomavirus (HPV) types 16 and 18 in penile carcinomas. Methods - Forty one surgically resected penile carcinomas from the archives at Queen Mary Hospital, Hong Kong, were reviewed and classified into verrucous carcinoma, and well, moderately, and poorly differentiated squamous cell carcinomas. Paraffin wax embedded tumour tissue was sectioned and analysed for HPV 16 and HPV 18 using the polymerase chain reaction with type specific internal probes. Results - There were seven verrucous carcinomas, and 11 well, 17 moderately, and six poorly differentiated squamous cell carcinomas. Six of the 41 (15%) patients had penile carcinoma containing HPV 16 or HPV 18 DNA, or both, with HPV 16 found in four (10%) and HPV 18 in four (10%). The mean ages of HPV positive and HPV negative groups of patients were 68.5 and 57.6 years, respectively (p < 0.05). None of the seven verrucous and 11 well differentiated squamous cell carcinomas was positive for HPV. The mean age of patients who had these carcinomas was 52.4 years. As a group, these low grade carcinomas occurred in patients younger by more than a decade than those who had carcinomas of the higher grades (mean age 64.4 years; p < 0.01). Conclusions - Penile carcinomas had much lower rates of infection by HPV 16 or HPV 18 than cervical carcinomas in this Hong Kong population. Based on our findings and on data collated from published findings, it is concluded that penile verrucous carcinomas are not associated with HPV 16 and HPV 18, The overall low prevalence of HPV 16 and HPV 18 in penile carcinomas suggests that other HPV types might be important in the pathogenesis of these tumours.en_HK
dc.format.extent644920 bytes-
dc.format.extent26112 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/msword-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/en_HK
dc.relation.ispartofJournal of Clinical Pathologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsJournal of Clinical Pathology. Copyright © B M J Publishing Group.en_HK
dc.subject.meshMolecular sequence dataen_HK
dc.subject.meshPolymerase chain reactionen_HK
dc.subject.meshRetrospective studiesen_HK
dc.subject.meshTumor virus infections - virologyen_HK
dc.subject.meshPapillomavirus, human - genetics - isolation & purificationen_HK
dc.titlePrevalence of human papillomavirus types 16 and 18 in penile carcinoma: A study of 41 cases using PCRen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9746&volume=47&issue=9&spage=823&epage=826&date=1994&atitle=Prevalence+of+human+papillomavirus+types+16+and+18+in+penile+carcinoma:+a+study+of+41+cases+using+PCRen_HK
dc.identifier.emailChan, KW:hrmtckw@hku.hken_HK
dc.identifier.emailSrivastava, G:gopesh@pathology.hku.hken_HK
dc.identifier.authorityChan, KW=rp00330en_HK
dc.identifier.authoritySrivastava, G=rp00365en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid7962651-
dc.identifier.pmcidPMC494939-
dc.identifier.scopuseid_2-s2.0-0028625469en_HK
dc.identifier.hkuros5240-
dc.identifier.volume47en_HK
dc.identifier.issue9en_HK
dc.identifier.spage823en_HK
dc.identifier.epage826en_HK
dc.identifier.isiWOS:A1994PG49000011-
dc.publisher.placeUnited Kingdomen_HK

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