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Article: Measurement of extent of spread of oesophageal squamous carcinoma by serial sectioning

TitleMeasurement of extent of spread of oesophageal squamous carcinoma by serial sectioning
Authors
KeywordsIntramural metastasis
Multiple primaries
Oesophagus
Squamous carcinoma
Issue Date1996
PublisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/
Citation
Journal Of Clinical Pathology, 1996, v. 49 n. 2, p. 124-129 How to Cite?
AbstractObjectives - (1) To examine the prevalence and extent of intramural metastasis in squamous cell carcinomas of the oesophagus so as to delineate the resection margins for these tumours; (2) to devise an appropriate method for measurement of these lesions which takes into account of the contraction of the specimens after resection. Methods - Oesophagectomy specimens were prospectively collected from 96 patients (87 males, nine females) with primary oesophageal squamous cell carcinoma over a two year period. The sizes of the tumours were measured in situ, after resection and after application of muscle relaxant (to regain their in situ length). The specimens were then serially sectioned for histological examination. Results - The sizes of the tumours measured after application of muscle relaxant roughly corresponded to those measured in situ. Intramural metastasis was observed in 26% of the cases. Sixty four per cent (16 cases) of these were on the oral side, 72% (18 cases) on the gastic side, and 25% (nine cases) on both sides of the tumours. The most distant extent of intramural metastasis from the primary tumour was from 0.5 cm to 7.7 cm (mean = 3.4 cm) on the oral side, and 0.5 to 9.5 cm (mean 4 cm) on the gastric aspect of the tumour. Intramural metastasis was seen only in patients in whom the primary cancer had deep muscle infiltration. Multiple neoplastic lesions could be detected in 33% of the patients. Both intramural metastasis and multiple neoplastic lesions were associated with extensive lymph node infiltration. However, they had different histological features and extent of infiltration. Conclusions-Intramural metastasis was frequently observed in oesophageal squamous cell carcinoma. This implies that excision with wide margins should be considered for local control of the disease.
Persistent Identifierhttp://hdl.handle.net/10722/43598
ISSN
2015 Impact Factor: 2.912
2015 SCImago Journal Rankings: 1.260
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, KYen_HK
dc.contributor.authorMa, LTen_HK
dc.contributor.authorWong, Jen_HK
dc.date.accessioned2007-03-23T04:50:00Z-
dc.date.available2007-03-23T04:50:00Z-
dc.date.issued1996en_HK
dc.identifier.citationJournal Of Clinical Pathology, 1996, v. 49 n. 2, p. 124-129en_HK
dc.identifier.issn0021-9746en_HK
dc.identifier.urihttp://hdl.handle.net/10722/43598-
dc.description.abstractObjectives - (1) To examine the prevalence and extent of intramural metastasis in squamous cell carcinomas of the oesophagus so as to delineate the resection margins for these tumours; (2) to devise an appropriate method for measurement of these lesions which takes into account of the contraction of the specimens after resection. Methods - Oesophagectomy specimens were prospectively collected from 96 patients (87 males, nine females) with primary oesophageal squamous cell carcinoma over a two year period. The sizes of the tumours were measured in situ, after resection and after application of muscle relaxant (to regain their in situ length). The specimens were then serially sectioned for histological examination. Results - The sizes of the tumours measured after application of muscle relaxant roughly corresponded to those measured in situ. Intramural metastasis was observed in 26% of the cases. Sixty four per cent (16 cases) of these were on the oral side, 72% (18 cases) on the gastic side, and 25% (nine cases) on both sides of the tumours. The most distant extent of intramural metastasis from the primary tumour was from 0.5 cm to 7.7 cm (mean = 3.4 cm) on the oral side, and 0.5 to 9.5 cm (mean 4 cm) on the gastric aspect of the tumour. Intramural metastasis was seen only in patients in whom the primary cancer had deep muscle infiltration. Multiple neoplastic lesions could be detected in 33% of the patients. Both intramural metastasis and multiple neoplastic lesions were associated with extensive lymph node infiltration. However, they had different histological features and extent of infiltration. Conclusions-Intramural metastasis was frequently observed in oesophageal squamous cell carcinoma. This implies that excision with wide margins should be considered for local control of the disease.en_HK
dc.format.extent1441447 bytes-
dc.format.extent27648 bytes-
dc.format.extent454989 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/msword-
dc.format.mimetypeapplication/pdf-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/en_HK
dc.relation.ispartofJournal of Clinical Pathologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsJournal of Clinical Pathology. Copyright © B M J Publishing Group.en_HK
dc.subjectIntramural metastasisen_HK
dc.subjectMultiple primariesen_HK
dc.subjectOesophagusen_HK
dc.subjectSquamous carcinomaen_HK
dc.subject.meshCarcinoma, squamous cell - pathology - secondary - surgeryen_HK
dc.subject.meshEsophageal neoplasms - pathology - surgeryen_HK
dc.subject.meshLymphatic metastasisen_HK
dc.subject.meshNeoplasm invasiveneen_HK
dc.subject.meshProspective studiesen_HK
dc.titleMeasurement of extent of spread of oesophageal squamous carcinoma by serial sectioningen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9746&volume=49&issue=2&spage=124&epage=129&date=1996&atitle=Measurement+of+extent+of+spread+of+oesophageal+squamous+carcinoma+by+serial+sectioningen_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid8655677-
dc.identifier.pmcidPMC500344-
dc.identifier.scopuseid_2-s2.0-0030038410en_HK
dc.identifier.hkuros14056-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030038410&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume49en_HK
dc.identifier.issue2en_HK
dc.identifier.spage124en_HK
dc.identifier.epage129en_HK
dc.identifier.isiWOS:A1996TV52700008-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLam, KY=7403657165en_HK
dc.identifier.scopusauthoridMa, LT=7403574642en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK

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