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Article: Comparison of the HbH inclusion test and a PCR test in routine screening for α thalassaemia in Hong Kong

TitleComparison of the HbH inclusion test and a PCR test in routine screening for α thalassaemia in Hong Kong
Authors
Keywords(--SEA/) deletion
HbH inclusion test
PCR
Thalassaemia
Issue Date1996
PublisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/
Citation
Journal Of Clinical Pathology, 1996, v. 49 n. 5, p. 411-413 How to Cite?
AbstractAim - To compare the haemoglobin (Hb) H inclusion test with a polymerase chain reaction CPCR) test in routine screening for or thalassaemia. Methods - Ninety nine peripheral blood samples from Chinese patients with mean corpuscular volume below 80fl were screened for a thalassaemia using the HbH inclusion test and by PCR utilising primers bridging the common deletion breakpoint of the South East Asian (--SEA/) deletion. Results - The HbH inclusion test was positive in 78 (79%) patients, 73 (93.7%) of whom carried the (--SEA/) deletion on analysis of their DNA by PCR, as did one patient with a negative HbH inclusion test. Conclusions - These results suggest that in areas with a high prevalence of the (--SEA/) deletion, such as Hong Kong, the HbH inclusion test can be replaced by PCR as the investigation of choice in screening for a thalassaemia.
Persistent Identifierhttp://hdl.handle.net/10722/43597
ISSN
2015 Impact Factor: 2.912
2015 SCImago Journal Rankings: 1.260
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, AYYen_HK
dc.contributor.authorSo, CKCen_HK
dc.contributor.authorChan, LCen_HK
dc.date.accessioned2007-03-23T04:49:58Z-
dc.date.available2007-03-23T04:49:58Z-
dc.date.issued1996en_HK
dc.identifier.citationJournal Of Clinical Pathology, 1996, v. 49 n. 5, p. 411-413en_HK
dc.identifier.issn0021-9746en_HK
dc.identifier.urihttp://hdl.handle.net/10722/43597-
dc.description.abstractAim - To compare the haemoglobin (Hb) H inclusion test with a polymerase chain reaction CPCR) test in routine screening for or thalassaemia. Methods - Ninety nine peripheral blood samples from Chinese patients with mean corpuscular volume below 80fl were screened for a thalassaemia using the HbH inclusion test and by PCR utilising primers bridging the common deletion breakpoint of the South East Asian (--SEA/) deletion. Results - The HbH inclusion test was positive in 78 (79%) patients, 73 (93.7%) of whom carried the (--SEA/) deletion on analysis of their DNA by PCR, as did one patient with a negative HbH inclusion test. Conclusions - These results suggest that in areas with a high prevalence of the (--SEA/) deletion, such as Hong Kong, the HbH inclusion test can be replaced by PCR as the investigation of choice in screening for a thalassaemia.en_HK
dc.format.extent754086 bytes-
dc.format.extent26624 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/msword-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/en_HK
dc.relation.ispartofJournal of Clinical Pathologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsJournal of Clinical Pathology. Copyright © B M J Publishing Group.en_HK
dc.subject(--SEA/) deletionen_HK
dc.subjectHbH inclusion testen_HK
dc.subjectPCRen_HK
dc.subjectThalassaemiaen_HK
dc.subject.meshHemoglobin h - chemistryen_HK
dc.subject.meshInclusion bodiesen_HK
dc.subject.meshPolymerase chain reactionen_HK
dc.subject.meshAlpha-thalassemia - diagnosisen_HK
dc.subject.meshDna primersen_HK
dc.titleComparison of the HbH inclusion test and a PCR test in routine screening for α thalassaemia in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9746&volume=49&issue=5&spage=411&epage=413&date=1996&atitle=Comparison+of+the+HbH+inclusion+test+and+a+PCR+test+in+routine+screening+for+alpha+thalassaemia+in+Hong+Kongen_HK
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_HK
dc.identifier.authorityChan, LC=rp00373en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid8707958-
dc.identifier.pmcidPMC500483-
dc.identifier.scopuseid_2-s2.0-0030032670en_HK
dc.identifier.hkuros14038-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030032670&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume49en_HK
dc.identifier.issue5en_HK
dc.identifier.spage411en_HK
dc.identifier.epage413en_HK
dc.identifier.isiWOS:A1996UL61000014-
dc.publisher.placeUnited Kingdomen_HK

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