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Article: The murine cataractogenic mutation, Cat Fraser, segregates independently of the gamma crystallin genes

TitleThe murine cataractogenic mutation, Cat Fraser, segregates independently of the gamma crystallin genes
Authors
Issue Date1988
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=GRH
Citation
Genetical Research, 1988, v. 51 n. 1, p. 23-28 How to Cite?
AbstractThe murine mutation, Cat Fraser (Cat(Fr)), causes dominantly inherited ocular cataracts. Lenses of adult mice bearing this mutation contain reduced amounts of all seven γ-crystallin proteins and their corresponding transcripts. Levels of other lens proteins and transcripts appear normal and no extra-ocular effects of the mutation have been observed. The selective effect of this mutation on the γ-crystallins is consistent with the possibility that the site at which it occurs is involved in the coordinated regulation of the family of genes which encodes them. We have shown that several restriction fragment length polymorphisms in the γ-crystallin genes segregate independently of the Cat(Fr) mutation. Therefore, despite its selective effect on the expression of the γ-crystallin genes, the mutation is not linked to them. This observation rules out the possibility that the mutation is in a cis-acting regulatory site.
Persistent Identifierhttp://hdl.handle.net/10722/43552
ISSN
2015 Impact Factor: 0.743
2015 SCImago Journal Rankings: 0.520
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRupert, JLen_HK
dc.contributor.authorKuliszewki, Men_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorBreitman, MLen_HK
dc.contributor.authorGold, RJMen_HK
dc.date.accessioned2007-03-23T04:48:49Z-
dc.date.available2007-03-23T04:48:49Z-
dc.date.issued1988en_HK
dc.identifier.citationGenetical Research, 1988, v. 51 n. 1, p. 23-28en_HK
dc.identifier.issn0016-6723en_HK
dc.identifier.urihttp://hdl.handle.net/10722/43552-
dc.description.abstractThe murine mutation, Cat Fraser (Cat(Fr)), causes dominantly inherited ocular cataracts. Lenses of adult mice bearing this mutation contain reduced amounts of all seven γ-crystallin proteins and their corresponding transcripts. Levels of other lens proteins and transcripts appear normal and no extra-ocular effects of the mutation have been observed. The selective effect of this mutation on the γ-crystallins is consistent with the possibility that the site at which it occurs is involved in the coordinated regulation of the family of genes which encodes them. We have shown that several restriction fragment length polymorphisms in the γ-crystallin genes segregate independently of the Cat(Fr) mutation. Therefore, despite its selective effect on the expression of the γ-crystallin genes, the mutation is not linked to them. This observation rules out the possibility that the mutation is in a cis-acting regulatory site.en_HK
dc.format.extent3870201 bytes-
dc.format.extent25088 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/msword-
dc.languageengen_HK
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=GRHen_HK
dc.relation.ispartofGenetical Researchen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsGenetical research. Copyright © Cambridge University Press.en_HK
dc.subject.meshCataract - geneticsen_HK
dc.subject.meshCrystallinsen_HK
dc.subject.meshMice, mutant strainsen_HK
dc.subject.meshGenes, dominanten_HK
dc.subject.meshMutationen_HK
dc.titleThe murine cataractogenic mutation, Cat Fraser, segregates independently of the gamma crystallin genesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0016-6723&volume=51&issue=1&spage=23&epage=28&date=1988&atitle=The+murine+cataractogenic+mutation,+Cat+Fraser,+segregates+independently+of+the+gamma+crystallin+genesen_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1017/S0016672300023909-
dc.identifier.pmid3366376-
dc.identifier.scopuseid_2-s2.0-0023865691en_HK
dc.identifier.volume51en_HK
dc.identifier.issue1en_HK
dc.identifier.spage23en_HK
dc.identifier.epage28en_HK
dc.identifier.isiWOS:A1988M615500006-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridRupert, JL=55392371400en_HK
dc.identifier.scopusauthoridKuliszewki, M=6504068181en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridBreitman, ML=7005448008en_HK
dc.identifier.scopusauthoridGold, RJM=24514035500en_HK

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