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Article: In vitro effects of Trichinella spiralis on muscle cells

TitleIn vitro effects of Trichinella spiralis on muscle cells
Authors
Issue Date1997
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=JHL
Citation
Journal of Helminthology, 1997, v. 71 n. 2, p. 113-118 How to Cite?
AbstractIntroduction of excretory/secretory (ES) products of both infective-stage and newborn larvae of Trichinella spiralis into cultures of primary rat myocytes elicited morphological and structural changes in the myotubes. They appeared more granular, thinner, and failed to form networks. The most prominent lesion was the formation of 'nodular' structures, each bearing an enlarged nucleus, along the myotubes. Each node contained numerous cavities enclosed by an intact sarcolemma. Co-culture of myocytes with newborn larvae also elicited nodular formation but each node contained a large central cavity encircled by smaller ones. An immunocytolocalization study using IFAT and laser confocal microscopy showed the presence of parasitic epitopes inside the nodes. However, ES products from adult worms did not affect the myotubes.
Persistent Identifierhttp://hdl.handle.net/10722/43521
ISSN
2015 Impact Factor: 1.63
2015 SCImago Journal Rankings: 0.562
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLeung, RKMen_HK
dc.contributor.authorKo, RCen_HK
dc.date.accessioned2007-03-23T04:47:52Z-
dc.date.available2007-03-23T04:47:52Z-
dc.date.issued1997en_HK
dc.identifier.citationJournal of Helminthology, 1997, v. 71 n. 2, p. 113-118en_HK
dc.identifier.issn0022-149Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/43521-
dc.description.abstractIntroduction of excretory/secretory (ES) products of both infective-stage and newborn larvae of Trichinella spiralis into cultures of primary rat myocytes elicited morphological and structural changes in the myotubes. They appeared more granular, thinner, and failed to form networks. The most prominent lesion was the formation of 'nodular' structures, each bearing an enlarged nucleus, along the myotubes. Each node contained numerous cavities enclosed by an intact sarcolemma. Co-culture of myocytes with newborn larvae also elicited nodular formation but each node contained a large central cavity encircled by smaller ones. An immunocytolocalization study using IFAT and laser confocal microscopy showed the presence of parasitic epitopes inside the nodes. However, ES products from adult worms did not affect the myotubes.en_HK
dc.format.extent1850468 bytes-
dc.format.extent25600 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/msword-
dc.languageengen_HK
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=JHLen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsJournal of Helminthology. Copyright © Cambridge University Press.en_HK
dc.subject.meshAntigens, helminth - pharmacologyen_HK
dc.subject.meshFluorescent antibody technique, indirecten_HK
dc.subject.meshHost-parasite relationsen_HK
dc.subject.meshMuscle, skeletalen_HK
dc.subject.meshParasitologyen_HK
dc.titleIn vitro effects of Trichinella spiralis on muscle cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-149X&volume=71&issue=2&spage=113&epage=118&date=1997&atitle=In+vitro+effects+of+Trichinella+spiralis+on+muscle+cellsen_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid9192713-
dc.identifier.scopuseid_2-s2.0-0031005648-
dc.identifier.hkuros23136-
dc.identifier.isiWOS:A1997XE21100007-

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