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Article: The differential clinical and neurocognitive profiles of COMT SNP rs165599 genotypes in schizophrenia
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TitleThe differential clinical and neurocognitive profiles of COMT SNP rs165599 genotypes in schizophrenia
 
AuthorsChan, RCK3 2
Chen, RYL2
Chen, EYH2
Hui, TCK2
Cheung, EFC4
Cheung, HK4
Sham, P2 1
Li, T1
Collier, D1
 
KeywordsMedical sciences - psychiatry and neurology
 
Issue Date2005
 
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=INS
 
CitationJournal Of The International Neuropsychological Society, 2005, v. 11 n. 2, p. 202-204 [How to Cite?]
DOI: http://dx.doi.org/10.1017/S1355617705050241
 
AbstractSchizophrenia is characterized by profound disturbances in cognition, emotion, and social functioning. Catechol-O-methyl transferase (COMT) is the important enzyme for the metabolism of monoamines, which play important part in the pathogenesis of schizophrenia. COMT exists in high and low activity forms. The low activity form was found to be an amino acid substitution (Val-108-Met), which reduces the thermostability of the enzyme. This genetic polymorphism has been reported to be associated with schizophrenia and its associated clinical features (Li et al., 1996).
 
ISSN1355-6177
2012 Impact Factor: 2.697
2012 SCImago Journal Rankings: 1.179
 
DOIhttp://dx.doi.org/10.1017/S1355617705050241
 
ISI Accession Number IDWOS:000228077900009
 
ReferencesReferences in Scopus
 
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dc.contributor.authorChan, RCK
 
dc.contributor.authorChen, RYL
 
dc.contributor.authorChen, EYH
 
dc.contributor.authorHui, TCK
 
dc.contributor.authorCheung, EFC
 
dc.contributor.authorCheung, HK
 
dc.contributor.authorSham, P
 
dc.contributor.authorLi, T
 
dc.contributor.authorCollier, D
 
dc.date.accessioned2007-03-23T04:46:44Z
 
dc.date.available2007-03-23T04:46:44Z
 
dc.date.issued2005
 
dc.description.abstractSchizophrenia is characterized by profound disturbances in cognition, emotion, and social functioning. Catechol-O-methyl transferase (COMT) is the important enzyme for the metabolism of monoamines, which play important part in the pathogenesis of schizophrenia. COMT exists in high and low activity forms. The low activity form was found to be an amino acid substitution (Val-108-Met), which reduces the thermostability of the enzyme. This genetic polymorphism has been reported to be associated with schizophrenia and its associated clinical features (Li et al., 1996).
 
dc.description.naturepublished_or_final_version
 
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dc.identifier.citationJournal Of The International Neuropsychological Society, 2005, v. 11 n. 2, p. 202-204 [How to Cite?]
DOI: http://dx.doi.org/10.1017/S1355617705050241
 
dc.identifier.doihttp://dx.doi.org/10.1017/S1355617705050241
 
dc.identifier.epage204
 
dc.identifier.hkuros104610
 
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dc.identifier.issn1355-6177
2012 Impact Factor: 2.697
2012 SCImago Journal Rankings: 1.179
 
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dc.identifier.urihttp://hdl.handle.net/10722/43484
 
dc.identifier.volume11
 
dc.languageeng
 
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=INS
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofJournal of the International Neuropsychological Society
 
dc.relation.referencesReferences in Scopus
 
dc.rightsJournal of International Neuropsychological Society. Copyright © Cambridge University Press.
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subjectMedical sciences - psychiatry and neurology
 
dc.titleThe differential clinical and neurocognitive profiles of COMT SNP rs165599 genotypes in schizophrenia
 
dc.typeArticle
 
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Author Affiliations
  1. King's College London
  2. The University of Hong Kong
  3. Sun Yat-Sen University
  4. Castle Peak Hospital Hong Kong