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Article: The differential clinical and neurocognitive profiles of COMT SNP rs165599 genotypes in schizophrenia

TitleThe differential clinical and neurocognitive profiles of COMT SNP rs165599 genotypes in schizophrenia
Authors
KeywordsMedical sciences - psychiatry and neurology
Issue Date2005
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=INS
Citation
Journal Of The International Neuropsychological Society, 2005, v. 11 n. 2, p. 202-204 How to Cite?
Abstract
Schizophrenia is characterized by profound disturbances in cognition, emotion, and social functioning. Catechol-O-methyl transferase (COMT) is the important enzyme for the metabolism of monoamines, which play important part in the pathogenesis of schizophrenia. COMT exists in high and low activity forms. The low activity form was found to be an amino acid substitution (Val-108-Met), which reduces the thermostability of the enzyme. This genetic polymorphism has been reported to be associated with schizophrenia and its associated clinical features (Li et al., 1996).
Persistent Identifierhttp://hdl.handle.net/10722/43484
ISSN
2013 Impact Factor: 3.009
ISI Accession Number ID
References

 

Author Affiliations
  1. King's College London
  2. The University of Hong Kong
  3. Sun Yat-Sen University
  4. Castle Peak Hospital Hong Kong
DC FieldValueLanguage
dc.contributor.authorChan, RCKen_HK
dc.contributor.authorChen, RYLen_HK
dc.contributor.authorChen, EYHen_HK
dc.contributor.authorHui, TCKen_HK
dc.contributor.authorCheung, EFCen_HK
dc.contributor.authorCheung, HKen_HK
dc.contributor.authorSham, Pen_HK
dc.contributor.authorLi, Ten_HK
dc.contributor.authorCollier, Den_HK
dc.date.accessioned2007-03-23T04:46:44Z-
dc.date.available2007-03-23T04:46:44Z-
dc.date.issued2005en_HK
dc.identifier.citationJournal Of The International Neuropsychological Society, 2005, v. 11 n. 2, p. 202-204en_HK
dc.identifier.issn1355-6177en_HK
dc.identifier.urihttp://hdl.handle.net/10722/43484-
dc.description.abstractSchizophrenia is characterized by profound disturbances in cognition, emotion, and social functioning. Catechol-O-methyl transferase (COMT) is the important enzyme for the metabolism of monoamines, which play important part in the pathogenesis of schizophrenia. COMT exists in high and low activity forms. The low activity form was found to be an amino acid substitution (Val-108-Met), which reduces the thermostability of the enzyme. This genetic polymorphism has been reported to be associated with schizophrenia and its associated clinical features (Li et al., 1996).en_HK
dc.format.extent31299 bytes-
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dc.format.extent1957 bytes-
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dc.languageengen_HK
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=INSen_HK
dc.relation.ispartofJournal of the International Neuropsychological Societyen_HK
dc.rightsJournal of International Neuropsychological Society. Copyright © Cambridge University Press.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectMedical sciences - psychiatry and neurologyen_HK
dc.titleThe differential clinical and neurocognitive profiles of COMT SNP rs165599 genotypes in schizophreniaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1355-6177&volume=11&issue=2&spage=202&epage=204&date=2005&atitle=The+differential+clinical+and+neurocognitive+profiles+of+COMT+SNP+rs165599+genotypes+in+schizophreniaen_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.emailSham, P: pcsham@hku.hken_HK
dc.identifier.authorityChen, EYH=rp00392en_HK
dc.identifier.authoritySham, P=rp00459en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1017/S1355617705050241en_HK
dc.identifier.pmid15962707en_HK
dc.identifier.scopuseid_2-s2.0-17644372678en_HK
dc.identifier.hkuros104610-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-17644372678&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue2en_HK
dc.identifier.spage202en_HK
dc.identifier.epage204en_HK
dc.identifier.isiWOS:000228077900009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChan, RCK=35236280300en_HK
dc.identifier.scopusauthoridChen, RYL=16635066600en_HK
dc.identifier.scopusauthoridChen, EYH=7402315729en_HK
dc.identifier.scopusauthoridHui, TCK=7005618911en_HK
dc.identifier.scopusauthoridCheung, EFC=7006522469en_HK
dc.identifier.scopusauthoridCheung, HK=7201839420en_HK
dc.identifier.scopusauthoridSham, P=34573429300en_HK
dc.identifier.scopusauthoridLi, T=36072008200en_HK
dc.identifier.scopusauthoridCollier, D=26642980600en_HK

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