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Article: The differential clinical and neurocognitive profiles of COMT SNP rs165599 genotypes in schizophrenia

TitleThe differential clinical and neurocognitive profiles of COMT SNP rs165599 genotypes in schizophrenia
Authors
Chan, RCKChen, RYLChen, EYHHui, TCKCheung, EFCCheung, HKSham, PLi, TCollier, D
KeywordsMedical sciences - psychiatry and neurology
Issue Date2005
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=INS
Citation
Journal Of The International Neuropsychological Society, 2005, v. 11 n. 2, p. 202-204 How to Cite?
DOI: http://dx.doi.org/10.1017/S1355617705050241
AbstractSchizophrenia is characterized by profound disturbances in cognition, emotion, and social functioning. Catechol-O-methyl transferase (COMT) is the important enzyme for the metabolism of monoamines, which play important part in the pathogenesis of schizophrenia. COMT exists in high and low activity forms. The low activity form was found to be an amino acid substitution (Val-108-Met), which reduces the thermostability of the enzyme. This genetic polymorphism has been reported to be associated with schizophrenia and its associated clinical features (Li et al., 1996).
Persistent Identifierhttp://hdl.handle.net/10722/43484
ISSN
1355-6177
2023 Impact Factor: 2.6
2023 SCImago Journal Rankings: 1.028
ISI Accession Number ID
WOS:000228077900009
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorChan, RCKen_HK
dc.contributor.authorChen, RYLen_HK
dc.contributor.authorChen, EYHen_HK
dc.contributor.authorHui, TCKen_HK
dc.contributor.authorCheung, EFCen_HK
dc.contributor.authorCheung, HKen_HK
dc.contributor.authorSham, Pen_HK
dc.contributor.authorLi, Ten_HK
dc.contributor.authorCollier, Den_HK
dc.date.accessioned2007-03-23T04:46:44Z-
dc.date.available2007-03-23T04:46:44Z-
dc.date.issued2005en_HK
dc.identifier.citationJournal Of The International Neuropsychological Society, 2005, v. 11 n. 2, p. 202-204en_HK
dc.identifier.issn1355-6177en_HK
dc.identifier.urihttp://hdl.handle.net/10722/43484-
dc.description.abstractSchizophrenia is characterized by profound disturbances in cognition, emotion, and social functioning. Catechol-O-methyl transferase (COMT) is the important enzyme for the metabolism of monoamines, which play important part in the pathogenesis of schizophrenia. COMT exists in high and low activity forms. The low activity form was found to be an amino acid substitution (Val-108-Met), which reduces the thermostability of the enzyme. This genetic polymorphism has been reported to be associated with schizophrenia and its associated clinical features (Li et al., 1996).en_HK
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dc.languageengen_HK
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=INSen_HK
dc.relation.ispartofJournal of the International Neuropsychological Societyen_HK
dc.rightsJournal of International Neuropsychological Society. Copyright © Cambridge University Press.en_HK
dc.subjectMedical sciences - psychiatry and neurologyen_HK
dc.titleThe differential clinical and neurocognitive profiles of COMT SNP rs165599 genotypes in schizophreniaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1355-6177&volume=11&issue=2&spage=202&epage=204&date=2005&atitle=The+differential+clinical+and+neurocognitive+profiles+of+COMT+SNP+rs165599+genotypes+in+schizophreniaen_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.emailSham, P: pcsham@hku.hken_HK
dc.identifier.authorityChen, EYH=rp00392en_HK
dc.identifier.authoritySham, P=rp00459en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1017/S1355617705050241en_HK
dc.identifier.pmid15962707-
dc.identifier.scopuseid_2-s2.0-17644372678en_HK
dc.identifier.hkuros104610-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-17644372678&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue2en_HK
dc.identifier.spage202en_HK
dc.identifier.epage204en_HK
dc.identifier.isiWOS:000228077900009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChan, RCK=35236280300en_HK
dc.identifier.scopusauthoridChen, RYL=16635066600en_HK
dc.identifier.scopusauthoridChen, EYH=7402315729en_HK
dc.identifier.scopusauthoridHui, TCK=7005618911en_HK
dc.identifier.scopusauthoridCheung, EFC=7006522469en_HK
dc.identifier.scopusauthoridCheung, HK=7201839420en_HK
dc.identifier.scopusauthoridSham, P=34573429300en_HK
dc.identifier.scopusauthoridLi, T=36072008200en_HK
dc.identifier.scopusauthoridCollier, D=26642980600en_HK
dc.identifier.issnl1355-6177-

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