Article: The differential clinical and neurocognitive profiles of COMT SNP rs165599 genotypes in schizophrenia

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TitleThe differential clinical and neurocognitive profiles of COMT SNP rs165599 genotypes in schizophrenia
AuthorsChan, RCK2 3
Chen, RYL2
Chen, EYH2
Hui, TCK2
Cheung, EFC4
Cheung, HK4
Sham, P1 2
Li, T1
Collier, D1
KeywordsMedical sciences - psychiatry and neurology
Issue Date2005
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=INS
CitationJournal Of The International Neuropsychological Society, 2005, v. 11 n. 2, p. 202-204 [How to Cite?]
DOI: http://dx.doi.org/10.1017/S1355617705050241
AbstractSchizophrenia is characterized by profound disturbances in cognition, emotion, and social functioning. Catechol-O-methyl transferase (COMT) is the important enzyme for the metabolism of monoamines, which play important part in the pathogenesis of schizophrenia. COMT exists in high and low activity forms. The low activity form was found to be an amino acid substitution (Val-108-Met), which reduces the thermostability of the enzyme. This genetic polymorphism has been reported to be associated with schizophrenia and its associated clinical features (Li et al., 1996).
ISSN1355-6177
2011 Impact Factor: 2.759
2011 SCImago Journal Rankings: 0.181
DOIhttp://dx.doi.org/10.1017/S1355617705050241
ISI Accession Number IDWOS:000228077900009
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorChan, RCK
dc.contributor.authorChen, RYL
dc.contributor.authorChen, EYH
dc.contributor.authorHui, TCK
dc.contributor.authorCheung, EFC
dc.contributor.authorCheung, HK
dc.contributor.authorSham, P
dc.contributor.authorLi, T
dc.contributor.authorCollier, D
dc.date.accessioned2007-03-23T04:46:44Z
dc.date.available2007-03-23T04:46:44Z
dc.date.issued2005
dc.description.abstractSchizophrenia is characterized by profound disturbances in cognition, emotion, and social functioning. Catechol-O-methyl transferase (COMT) is the important enzyme for the metabolism of monoamines, which play important part in the pathogenesis of schizophrenia. COMT exists in high and low activity forms. The low activity form was found to be an amino acid substitution (Val-108-Met), which reduces the thermostability of the enzyme. This genetic polymorphism has been reported to be associated with schizophrenia and its associated clinical features (Li et al., 1996).
dc.description.naturepublished_or_final_version
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dc.format.mimetypetext/plain
dc.identifier.citationJournal Of The International Neuropsychological Society, 2005, v. 11 n. 2, p. 202-204 [How to Cite?]
DOI: http://dx.doi.org/10.1017/S1355617705050241
dc.identifier.doihttp://dx.doi.org/10.1017/S1355617705050241
dc.identifier.epage204
dc.identifier.hkuros104610
dc.identifier.isiWOS:000228077900009
dc.identifier.issn1355-6177
2011 Impact Factor: 2.759
2011 SCImago Journal Rankings: 0.181
dc.identifier.issue2
dc.identifier.openurl
dc.identifier.pmid15962707
dc.identifier.scopuseid_2-s2.0-17644372678
dc.identifier.spage202
dc.identifier.urihttp://hdl.handle.net/10722/43484
dc.identifier.volume11
dc.languageeng
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=INS
dc.publisher.placeUnited Kingdom
dc.relation.ispartofJournal of the International Neuropsychological Society
dc.relation.referencesReferences in Scopus
dc.rightsJournal of International Neuropsychological Society. Copyright © Cambridge University Press.
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.subjectMedical sciences - psychiatry and neurology
dc.titleThe differential clinical and neurocognitive profiles of COMT SNP rs165599 genotypes in schizophrenia
dc.typeArticle
Author Affiliations
  1. King's College London
  2. The University of Hong Kong
  3. Sun Yat-Sen University
  4. Castle Peak Hospital Hong Kong