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Article: Role of mannose-binding lectin in the innate defense against Candida albicans: Enhancement of complement activation, but lack of opsonic function, in phagocytosis by human dendritic cells

TitleRole of mannose-binding lectin in the innate defense against Candida albicans: Enhancement of complement activation, but lack of opsonic function, in phagocytosis by human dendritic cells
Authors
Issue Date2004
PublisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
Citation
Journal Of Infectious Diseases, 2004, v. 190 n. 3, p. 632-640 How to Cite?
AbstractMannose-binding lectin (MBL) is a serum collectin believed to be of importance in innate immunity. We have investigated the role of MBL in the first-line defense against Candida albicans, an opportunistic fungal pathogen. MBL bound C. albicans via its lectin domain, resulting in agglutination of the organisms upon their outgrowth of hyphae. In a human in vitro MBL system, deposition of C4 fragments on C. albicans was increased when exogenous MBL was added to serum samples from MBL-deficient individuals. Similar enhancement of deposition of iC3b also was observed. MBL and enhanced opsonic C3 fragments mediated by MBL did not facilitate opsonophagocytosis of the organisms by monocyte-derived dendritic cells (DCs). However, MBL was found to inhibit the growth of C. albicans independently of complement activation, although, with complement activation, further inhibition was observed. We concluded that MBL plays an important role in the first-line defense against C. albicans without the need for opsonophagocytosis by DCs, in which a direct interaction of MBL with C. albicans results in agglutination and accelerated complement activation via the lectin pathway, leading to inhibition of growth.
Persistent Identifierhttp://hdl.handle.net/10722/43148
ISSN
2015 Impact Factor: 6.344
2015 SCImago Journal Rankings: 4.000
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorIp, WKen_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2007-03-23T04:39:59Z-
dc.date.available2007-03-23T04:39:59Z-
dc.date.issued2004en_HK
dc.identifier.citationJournal Of Infectious Diseases, 2004, v. 190 n. 3, p. 632-640en_HK
dc.identifier.issn0022-1899en_HK
dc.identifier.urihttp://hdl.handle.net/10722/43148-
dc.description.abstractMannose-binding lectin (MBL) is a serum collectin believed to be of importance in innate immunity. We have investigated the role of MBL in the first-line defense against Candida albicans, an opportunistic fungal pathogen. MBL bound C. albicans via its lectin domain, resulting in agglutination of the organisms upon their outgrowth of hyphae. In a human in vitro MBL system, deposition of C4 fragments on C. albicans was increased when exogenous MBL was added to serum samples from MBL-deficient individuals. Similar enhancement of deposition of iC3b also was observed. MBL and enhanced opsonic C3 fragments mediated by MBL did not facilitate opsonophagocytosis of the organisms by monocyte-derived dendritic cells (DCs). However, MBL was found to inhibit the growth of C. albicans independently of complement activation, although, with complement activation, further inhibition was observed. We concluded that MBL plays an important role in the first-line defense against C. albicans without the need for opsonophagocytosis by DCs, in which a direct interaction of MBL with C. albicans results in agglutination and accelerated complement activation via the lectin pathway, leading to inhibition of growth.en_HK
dc.format.extent541172 bytes-
dc.format.extent3258 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org en_HK
dc.relation.ispartofJournal of Infectious Diseasesen_HK
dc.rightsJournal of Infectious Diseases. Copyright © University of Chicago Press.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshCandida albicans - growth & development - metabolism - pathogenicityen_HK
dc.subject.meshComplement pathway, mannose-binding lectinen_HK
dc.subject.meshDendritic cells - immunology - microbiologyen_HK
dc.subject.meshImmunity, naturalen_HK
dc.subject.meshMannose-binding lectin - metabolismen_HK
dc.titleRole of mannose-binding lectin in the innate defense against Candida albicans: Enhancement of complement activation, but lack of opsonic function, in phagocytosis by human dendritic cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-1899&volume=190&issue=3&spage=632&epage=640&date=2004&atitle=Role+of+Mannose-Binding+Lectin+in+the+Innate+Defense+against+Candida+albicans:+Enhancement+of+Complement+Activation,+but+Lack+of+Opsonic+Function,+in+Phagocytosis+by+Human+Dendritic+Cellsen_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1086/422397en_HK
dc.identifier.pmid15243942-
dc.identifier.scopuseid_2-s2.0-3242748243en_HK
dc.identifier.hkuros90176-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-3242748243&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume190en_HK
dc.identifier.issue3en_HK
dc.identifier.spage632en_HK
dc.identifier.epage640en_HK
dc.identifier.isiWOS:000222549500030-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridIp, WK=35991732900en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK

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