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Article: Klebsiella infection in patients with thalassemia

TitleKlebsiella infection in patients with thalassemia
Authors
Issue Date2003
PublisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/cid/
Citation
Clinical Infectious Diseases, 2003, v. 36 n. 5, p. 575-579 How to Cite?
Abstract
Klebsiella infection has previously been reported in a few patients with transfusion-dependent thalassemia. The incidence and clinical spectrum of this infection in our cohort of patients were reviewed retrospectively. Among 160 patients observed for 12 years, there were 15 episodes of Klebsiella infection that occurred in 12 patients (7.5%), resulting in an incidence of 0.78 infections per 100 patient-years. The clinical spectrum included sinusitis (4 cases), intracranial infection (5 cases), septicemia (4 cases), and abscesses of the liver, lung, kidney, and parotid gland (1 case each). Three patients had recurrent infections involving different sites, 2 (16%) died of fulminant septicemia, and 3 (25%) had significant permanent neurological deficits. The antibiotic susceptibility pattern for the isolates was similar to the pattern for isolates recovered in the community. With regard to predisposing factors, iron overload and liver function derangement were found to be significant on univariate analysis (P = .046 and P = .049, respectively) but insignificant on multivariate analysis. Klebsiella infection was a serious and frequently encountered complication in our patients with transfusion-dependent thalassemia, resulting in high mortality and morbidity rates.
Persistent Identifierhttp://hdl.handle.net/10722/43146
ISSN
2013 Impact Factor: 9.416
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong
  2. Queen Elizabeth Hospital Hong Kong
  3. Caritas Medical Centre Hong Kong
DC FieldValueLanguage
dc.contributor.authorChung, BHYen_HK
dc.contributor.authorHa, SYen_HK
dc.contributor.authorChan, GCFen_HK
dc.contributor.authorChiang, Aen_HK
dc.contributor.authorLee, TLen_HK
dc.contributor.authorHo, HKen_HK
dc.contributor.authorLee, CYen_HK
dc.contributor.authorLuk, CWen_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2007-03-23T04:39:57Z-
dc.date.available2007-03-23T04:39:57Z-
dc.date.issued2003en_HK
dc.identifier.citationClinical Infectious Diseases, 2003, v. 36 n. 5, p. 575-579en_HK
dc.identifier.issn1058-4838en_HK
dc.identifier.urihttp://hdl.handle.net/10722/43146-
dc.description.abstractKlebsiella infection has previously been reported in a few patients with transfusion-dependent thalassemia. The incidence and clinical spectrum of this infection in our cohort of patients were reviewed retrospectively. Among 160 patients observed for 12 years, there were 15 episodes of Klebsiella infection that occurred in 12 patients (7.5%), resulting in an incidence of 0.78 infections per 100 patient-years. The clinical spectrum included sinusitis (4 cases), intracranial infection (5 cases), septicemia (4 cases), and abscesses of the liver, lung, kidney, and parotid gland (1 case each). Three patients had recurrent infections involving different sites, 2 (16%) died of fulminant septicemia, and 3 (25%) had significant permanent neurological deficits. The antibiotic susceptibility pattern for the isolates was similar to the pattern for isolates recovered in the community. With regard to predisposing factors, iron overload and liver function derangement were found to be significant on univariate analysis (P = .046 and P = .049, respectively) but insignificant on multivariate analysis. Klebsiella infection was a serious and frequently encountered complication in our patients with transfusion-dependent thalassemia, resulting in high mortality and morbidity rates.en_HK
dc.format.extent86224 bytes-
dc.format.extent2190 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/cid/en_HK
dc.relation.ispartofClinical Infectious Diseasesen_HK
dc.rightsClinical Infectious Diseases. Copyright © University of Chicago Press.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAdolescenten_HK
dc.subject.meshAnti-bacterial agents - therapeutic useen_HK
dc.subject.meshKlebsiella infections - complications - drug therapy - epidemiologyen_HK
dc.subject.meshKlebsiella pneumoniae - drug effectsen_HK
dc.subject.meshThalassemia - complicationsen_HK
dc.titleKlebsiella infection in patients with thalassemiaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1058-4838&volume=36&issue=5&spage=575&epage=579&date=2003&atitle=Klebsiella+infection+in+patients+with+thalassemiaen_HK
dc.identifier.emailChung, BHY:bhychung@hku.hken_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.emailChiang, A:chiangak@hkucc.hku.hken_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityChung, BHY=rp00473en_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.identifier.authorityChiang, A=rp00403en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1086/367656en_HK
dc.identifier.pmid12594637en_HK
dc.identifier.scopuseid_2-s2.0-0037370120en_HK
dc.identifier.hkuros76040-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037370120&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume36en_HK
dc.identifier.issue5en_HK
dc.identifier.spage575en_HK
dc.identifier.epage579en_HK
dc.identifier.isiWOS:000181073600005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChung, BHY=7203043997en_HK
dc.identifier.scopusauthoridHa, SY=7202501115en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK
dc.identifier.scopusauthoridChiang, A=7101623534en_HK
dc.identifier.scopusauthoridLee, TL=24483772800en_HK
dc.identifier.scopusauthoridHo, HK=7401465257en_HK
dc.identifier.scopusauthoridLee, CY=7410150061en_HK
dc.identifier.scopusauthoridLuk, CW=7005748744en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK

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