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Article: Klebsiella infection in patients with thalassemia
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TitleKlebsiella infection in patients with thalassemia
 
AuthorsChung, BHY1
Ha, SY1
Chan, GCF1
Chiang, A1
Lee, TL1
Ho, HK1
Lee, CY3
Luk, CW2
Lau, YL1
 
Issue Date2003
 
PublisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/cid/
 
CitationClinical Infectious Diseases, 2003, v. 36 n. 5, p. 575-579 [How to Cite?]
DOI: http://dx.doi.org/10.1086/367656
 
AbstractKlebsiella infection has previously been reported in a few patients with transfusion-dependent thalassemia. The incidence and clinical spectrum of this infection in our cohort of patients were reviewed retrospectively. Among 160 patients observed for 12 years, there were 15 episodes of Klebsiella infection that occurred in 12 patients (7.5%), resulting in an incidence of 0.78 infections per 100 patient-years. The clinical spectrum included sinusitis (4 cases), intracranial infection (5 cases), septicemia (4 cases), and abscesses of the liver, lung, kidney, and parotid gland (1 case each). Three patients had recurrent infections involving different sites, 2 (16%) died of fulminant septicemia, and 3 (25%) had significant permanent neurological deficits. The antibiotic susceptibility pattern for the isolates was similar to the pattern for isolates recovered in the community. With regard to predisposing factors, iron overload and liver function derangement were found to be significant on univariate analysis (P = .046 and P = .049, respectively) but insignificant on multivariate analysis. Klebsiella infection was a serious and frequently encountered complication in our patients with transfusion-dependent thalassemia, resulting in high mortality and morbidity rates.
 
ISSN1058-4838
2012 Impact Factor: 9.374
2012 SCImago Journal Rankings: 3.728
 
DOIhttp://dx.doi.org/10.1086/367656
 
ISI Accession Number IDWOS:000181073600005
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChung, BHY
 
dc.contributor.authorHa, SY
 
dc.contributor.authorChan, GCF
 
dc.contributor.authorChiang, A
 
dc.contributor.authorLee, TL
 
dc.contributor.authorHo, HK
 
dc.contributor.authorLee, CY
 
dc.contributor.authorLuk, CW
 
dc.contributor.authorLau, YL
 
dc.date.accessioned2007-03-23T04:39:57Z
 
dc.date.available2007-03-23T04:39:57Z
 
dc.date.issued2003
 
dc.description.abstractKlebsiella infection has previously been reported in a few patients with transfusion-dependent thalassemia. The incidence and clinical spectrum of this infection in our cohort of patients were reviewed retrospectively. Among 160 patients observed for 12 years, there were 15 episodes of Klebsiella infection that occurred in 12 patients (7.5%), resulting in an incidence of 0.78 infections per 100 patient-years. The clinical spectrum included sinusitis (4 cases), intracranial infection (5 cases), septicemia (4 cases), and abscesses of the liver, lung, kidney, and parotid gland (1 case each). Three patients had recurrent infections involving different sites, 2 (16%) died of fulminant septicemia, and 3 (25%) had significant permanent neurological deficits. The antibiotic susceptibility pattern for the isolates was similar to the pattern for isolates recovered in the community. With regard to predisposing factors, iron overload and liver function derangement were found to be significant on univariate analysis (P = .046 and P = .049, respectively) but insignificant on multivariate analysis. Klebsiella infection was a serious and frequently encountered complication in our patients with transfusion-dependent thalassemia, resulting in high mortality and morbidity rates.
 
dc.description.naturepublished_or_final_version
 
dc.format.extent86224 bytes
 
dc.format.extent2190 bytes
 
dc.format.mimetypeapplication/pdf
 
dc.format.mimetypetext/plain
 
dc.identifier.citationClinical Infectious Diseases, 2003, v. 36 n. 5, p. 575-579 [How to Cite?]
DOI: http://dx.doi.org/10.1086/367656
 
dc.identifier.doihttp://dx.doi.org/10.1086/367656
 
dc.identifier.epage579
 
dc.identifier.hkuros76040
 
dc.identifier.isiWOS:000181073600005
 
dc.identifier.issn1058-4838
2012 Impact Factor: 9.374
2012 SCImago Journal Rankings: 3.728
 
dc.identifier.issue5
 
dc.identifier.openurl
 
dc.identifier.pmid12594637
 
dc.identifier.scopuseid_2-s2.0-0037370120
 
dc.identifier.spage575
 
dc.identifier.urihttp://hdl.handle.net/10722/43146
 
dc.identifier.volume36
 
dc.languageeng
 
dc.publisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/cid/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofClinical Infectious Diseases
 
dc.relation.referencesReferences in Scopus
 
dc.rightsClinical Infectious Diseases. Copyright © University of Chicago Press.
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshAdolescent
 
dc.subject.meshAnti-bacterial agents - therapeutic use
 
dc.subject.meshKlebsiella infections - complications - drug therapy - epidemiology
 
dc.subject.meshKlebsiella pneumoniae - drug effects
 
dc.subject.meshThalassemia - complications
 
dc.titleKlebsiella infection in patients with thalassemia
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Queen Elizabeth Hospital Hong Kong
  3. Caritas Medical Centre Hong Kong