Article: Klebsiella infection in patients with thalassemia

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TitleKlebsiella infection in patients with thalassemia
AuthorsChung, BHY1
Ha, SY1
Chan, GCF1
Chiang, A1
Lee, TL1
Ho, HK1
Lee, CY3
Luk, CW2
Lau, YL1
Issue Date2003
PublisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/cid/
CitationClinical Infectious Diseases, 2003, v. 36 n. 5, p. 575-579 [How to Cite?]
DOI: http://dx.doi.org/10.1086/367656
AbstractKlebsiella infection has previously been reported in a few patients with transfusion-dependent thalassemia. The incidence and clinical spectrum of this infection in our cohort of patients were reviewed retrospectively. Among 160 patients observed for 12 years, there were 15 episodes of Klebsiella infection that occurred in 12 patients (7.5%), resulting in an incidence of 0.78 infections per 100 patient-years. The clinical spectrum included sinusitis (4 cases), intracranial infection (5 cases), septicemia (4 cases), and abscesses of the liver, lung, kidney, and parotid gland (1 case each). Three patients had recurrent infections involving different sites, 2 (16%) died of fulminant septicemia, and 3 (25%) had significant permanent neurological deficits. The antibiotic susceptibility pattern for the isolates was similar to the pattern for isolates recovered in the community. With regard to predisposing factors, iron overload and liver function derangement were found to be significant on univariate analysis (P = .046 and P = .049, respectively) but insignificant on multivariate analysis. Klebsiella infection was a serious and frequently encountered complication in our patients with transfusion-dependent thalassemia, resulting in high mortality and morbidity rates.
ISSN1058-4838
2011 Impact Factor: 9.154
2011 SCImago Journal Rankings: 0.821
DOIhttp://dx.doi.org/10.1086/367656
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorChung, BHY
dc.contributor.authorHa, SY
dc.contributor.authorChan, GCF
dc.contributor.authorChiang, A
dc.contributor.authorLee, TL
dc.contributor.authorHo, HK
dc.contributor.authorLee, CY
dc.contributor.authorLuk, CW
dc.contributor.authorLau, YL
dc.date.accessioned2007-03-23T04:39:57Z
dc.date.available2007-03-23T04:39:57Z
dc.date.issued2003
dc.description.abstractKlebsiella infection has previously been reported in a few patients with transfusion-dependent thalassemia. The incidence and clinical spectrum of this infection in our cohort of patients were reviewed retrospectively. Among 160 patients observed for 12 years, there were 15 episodes of Klebsiella infection that occurred in 12 patients (7.5%), resulting in an incidence of 0.78 infections per 100 patient-years. The clinical spectrum included sinusitis (4 cases), intracranial infection (5 cases), septicemia (4 cases), and abscesses of the liver, lung, kidney, and parotid gland (1 case each). Three patients had recurrent infections involving different sites, 2 (16%) died of fulminant septicemia, and 3 (25%) had significant permanent neurological deficits. The antibiotic susceptibility pattern for the isolates was similar to the pattern for isolates recovered in the community. With regard to predisposing factors, iron overload and liver function derangement were found to be significant on univariate analysis (P = .046 and P = .049, respectively) but insignificant on multivariate analysis. Klebsiella infection was a serious and frequently encountered complication in our patients with transfusion-dependent thalassemia, resulting in high mortality and morbidity rates.
dc.description.naturepublished_or_final_version
dc.format.extent86224 bytes
dc.format.extent2190 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.identifier.citationClinical Infectious Diseases, 2003, v. 36 n. 5, p. 575-579 [How to Cite?]
DOI: http://dx.doi.org/10.1086/367656
dc.identifier.doihttp://dx.doi.org/10.1086/367656
dc.identifier.epage579
dc.identifier.hkuros76040
dc.identifier.isiWOS:000181073600005
dc.identifier.issn1058-4838
2011 Impact Factor: 9.154
2011 SCImago Journal Rankings: 0.821
dc.identifier.issue5
dc.identifier.openurl
dc.identifier.pmid12594637
dc.identifier.scopuseid_2-s2.0-0037370120
dc.identifier.spage575
dc.identifier.urihttp://hdl.handle.net/10722/43146
dc.identifier.volume36
dc.languageeng
dc.publisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/cid/
dc.publisher.placeUnited States
dc.relation.ispartofClinical Infectious Diseases
dc.relation.referencesReferences in Scopus
dc.rightsClinical Infectious Diseases. Copyright © University of Chicago Press.
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.subject.meshAdolescent
dc.subject.meshAnti-bacterial agents - therapeutic use
dc.subject.meshKlebsiella infections - complications - drug therapy - epidemiology
dc.subject.meshKlebsiella pneumoniae - drug effects
dc.subject.meshThalassemia - complications
dc.titleKlebsiella infection in patients with thalassemia
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Queen Elizabeth Hospital Hong Kong
  3. Caritas Medical Centre Hong Kong