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Article: A cluster of cases of severe acute respiratory syndrome in Hong Kong

TitleA cluster of cases of severe acute respiratory syndrome in Hong Kong
Authors
Issue Date2003
PublisherMassachusetts Medical Society. The Journal's web site is located at http://content.nejm.org/
Citation
New England Journal Of Medicine, 2003, v. 348 n. 20, p. 1977-1985 How to Cite?
AbstractBACKGROUND: Information on the clinical features of the severe acute respiratory syndrome (SARS) will be of value to physicians caring for patients suspected of having this disorder. METHODS: We abstracted data on the clinical presentation and course of disease in 10 epidemiologically linked Chinese patients (5 men and 5 women 38 to 72 years old) in whom SARS was diagnosed between February 22, 2003, and March 22, 2003, at our hospitals in Hong Kong, China. RESULTS: Exposure between the source patient and subsequent patients ranged from minimal to that between patient and health care provider. The incubation period ranged from 2 to 11 days. All patients presented with fever (temperature, >38°C for over 24 hours), and most presented with rigor, dry cough, dyspnea, malaise, headache, and hypoxemia. Physical examination of the chest revealed crackles and percussion dullness. Lymphopenia was observed in nine patients, and most patients had mildly elevated aminotransferase levels but normal serum creatinine levels. Serial chest radiographs showed progressive air-space disease. Two patients died of progressive respiratory failure; histologic analysis of their lungs showed diffuse alveolar damage. There was no evidence of infection by Mycoplasma pneumoniae, Chlamydia pneumoniae, or Legionella pneumophila. All patients received corticosteroid and ribavirin therapy a mean (±SD) of 9.6±5.42 days after the onset of symptoms, and eight were treated earlier with a combination of beta-lactams and macrolide for 4±1.9 days, with no clinical or radiologic efficacy. CONCLUSIONS: SARS appears to be infectious in origin. Fever followed by rapidly progressive respiratory compromise is the key complex of signs and symptoms from which the syndrome derives its name. The microbiologic origins of SARS remain unclear.
Persistent Identifierhttp://hdl.handle.net/10722/43134
ISSN
2015 Impact Factor: 59.558
2015 SCImago Journal Rankings: 14.619
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTsang, KWen_HK
dc.contributor.authorHo, PLen_HK
dc.contributor.authorOoi, GCen_HK
dc.contributor.authorYee, WKen_HK
dc.contributor.authorWang, Ten_HK
dc.contributor.authorChanYeung, Men_HK
dc.contributor.authorLam, WKen_HK
dc.contributor.authorSeto, WHen_HK
dc.contributor.authorYam, LYen_HK
dc.contributor.authorCheung, TMen_HK
dc.contributor.authorWong, PCen_HK
dc.contributor.authorLam, Ben_HK
dc.contributor.authorIp, MSen_HK
dc.contributor.authorChan, Jen_HK
dc.contributor.authorYuen, KYen_HK
dc.contributor.authorLai, KNen_HK
dc.date.accessioned2007-03-23T04:39:39Z-
dc.date.available2007-03-23T04:39:39Z-
dc.date.issued2003en_HK
dc.identifier.citationNew England Journal Of Medicine, 2003, v. 348 n. 20, p. 1977-1985en_HK
dc.identifier.issn0028-4793en_HK
dc.identifier.urihttp://hdl.handle.net/10722/43134-
dc.description.abstractBACKGROUND: Information on the clinical features of the severe acute respiratory syndrome (SARS) will be of value to physicians caring for patients suspected of having this disorder. METHODS: We abstracted data on the clinical presentation and course of disease in 10 epidemiologically linked Chinese patients (5 men and 5 women 38 to 72 years old) in whom SARS was diagnosed between February 22, 2003, and March 22, 2003, at our hospitals in Hong Kong, China. RESULTS: Exposure between the source patient and subsequent patients ranged from minimal to that between patient and health care provider. The incubation period ranged from 2 to 11 days. All patients presented with fever (temperature, >38°C for over 24 hours), and most presented with rigor, dry cough, dyspnea, malaise, headache, and hypoxemia. Physical examination of the chest revealed crackles and percussion dullness. Lymphopenia was observed in nine patients, and most patients had mildly elevated aminotransferase levels but normal serum creatinine levels. Serial chest radiographs showed progressive air-space disease. Two patients died of progressive respiratory failure; histologic analysis of their lungs showed diffuse alveolar damage. There was no evidence of infection by Mycoplasma pneumoniae, Chlamydia pneumoniae, or Legionella pneumophila. All patients received corticosteroid and ribavirin therapy a mean (±SD) of 9.6±5.42 days after the onset of symptoms, and eight were treated earlier with a combination of beta-lactams and macrolide for 4±1.9 days, with no clinical or radiologic efficacy. CONCLUSIONS: SARS appears to be infectious in origin. Fever followed by rapidly progressive respiratory compromise is the key complex of signs and symptoms from which the syndrome derives its name. The microbiologic origins of SARS remain unclear.en_HK
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dc.languageengen_HK
dc.publisherMassachusetts Medical Society. The Journal's web site is located at http://content.nejm.org/en_HK
dc.relation.ispartofNew England Journal of Medicineen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsNew England Journal of Medicine. Copyright © Massachusetts Medical Society.en_HK
dc.subject.meshDisease outbreaksen_HK
dc.subject.meshDrug therapy, combinationen_HK
dc.subject.meshHong kong - epidemiologyen_HK
dc.subject.meshLung - radiographyen_HK
dc.subject.meshRibavirin - therapeutic useen_HK
dc.titleA cluster of cases of severe acute respiratory syndrome in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0028-4793&volume=348&issue=20&spage=1977&epage=1985&date=2003&atitle=A+cluster+of+cases+of+severe+acute+respiratory+syndrome+in+Hong+Kongen_HK
dc.identifier.emailHo, PL: plho@hkucc.hku.hken_HK
dc.identifier.emailIp, MS: msmip@hku.hken_HK
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hken_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityHo, PL=rp00406en_HK
dc.identifier.authorityIp, MS=rp00347en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1056/NEJMoa030666en_HK
dc.identifier.pmid12671062-
dc.identifier.scopuseid_2-s2.0-0013255608en_HK
dc.identifier.hkuros79043-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0013255608&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume348en_HK
dc.identifier.issue20en_HK
dc.identifier.spage1977en_HK
dc.identifier.epage1985en_HK
dc.identifier.isiWOS:000182823400006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTsang, KW=7201555024en_HK
dc.identifier.scopusauthoridHo, PL=7402211363en_HK
dc.identifier.scopusauthoridOoi, GC=7006176119en_HK
dc.identifier.scopusauthoridYee, WK=7005216073en_HK
dc.identifier.scopusauthoridWang, T=7405566621en_HK
dc.identifier.scopusauthoridChanYeung, M=54790582200en_HK
dc.identifier.scopusauthoridLam, WK=7203021937en_HK
dc.identifier.scopusauthoridSeto, WH=7005799377en_HK
dc.identifier.scopusauthoridYam, LY=7102764741en_HK
dc.identifier.scopusauthoridCheung, TM=7103334508en_HK
dc.identifier.scopusauthoridWong, PC=7403979916en_HK
dc.identifier.scopusauthoridLam, B=9246012800en_HK
dc.identifier.scopusauthoridIp, MS=7102423259en_HK
dc.identifier.scopusauthoridChan, J=27169797600en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK

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