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Article: Bacteremia caused by staphylococci with inducible vancomycin heteroresistance

TitleBacteremia caused by staphylococci with inducible vancomycin heteroresistance
Authors
Issue Date1999
PublisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/cid/
Citation
Clinical Infectious Diseases, 1999, v. 29 n. 4, p. 760-767 How to Cite?
AbstractThe clinical significance of bacteremia due to vancomycin- heteroresistant staphylococci and a rapid laboratory screening method were examined; 203 strains of staphylococci isolated from patients with clinically significant bacteremia were screened by the disk-agar method with use of vancomycin-salt agar to demonstrate satellitism around an aztreonam disk as well as by conventional population screening. Eighteen isolates (three Staphylococcus aureus and 15 coagulase-negative staphylococci) were shown to be heteroresistant to vancomycin. A case-control clinical study showed that the interval between admission and bacteremia, admission to the intensive care unit, prior use of vancomycin and/or β-lactams, and isolation of methicillin-resistant staphylococci were significantly more common among patients with bacteremia due to staphylococci with heteroresistance to vancomycin; these patients had an overall mortality of 44.4%. The use of vancomycin and admission to the intensive care unit were independently significant risk factors on multivariate analysis. Vancomycin heteroresistance is inducible by salt and β-lactams. Indiscriminate sequential use of β-lactams and glycopeptides may facilitate the emergence of glycopeptide resistance.
Persistent Identifierhttp://hdl.handle.net/10722/43128
ISSN
2015 Impact Factor: 8.736
2015 SCImago Journal Rankings: 4.742
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, SSYen_HK
dc.contributor.authorHo, PLen_HK
dc.contributor.authorWoo, PCYen_HK
dc.contributor.authorYuen, KYen_HK
dc.date.accessioned2007-03-23T04:39:31Z-
dc.date.available2007-03-23T04:39:31Z-
dc.date.issued1999en_HK
dc.identifier.citationClinical Infectious Diseases, 1999, v. 29 n. 4, p. 760-767en_HK
dc.identifier.issn1058-4838en_HK
dc.identifier.urihttp://hdl.handle.net/10722/43128-
dc.description.abstractThe clinical significance of bacteremia due to vancomycin- heteroresistant staphylococci and a rapid laboratory screening method were examined; 203 strains of staphylococci isolated from patients with clinically significant bacteremia were screened by the disk-agar method with use of vancomycin-salt agar to demonstrate satellitism around an aztreonam disk as well as by conventional population screening. Eighteen isolates (three Staphylococcus aureus and 15 coagulase-negative staphylococci) were shown to be heteroresistant to vancomycin. A case-control clinical study showed that the interval between admission and bacteremia, admission to the intensive care unit, prior use of vancomycin and/or β-lactams, and isolation of methicillin-resistant staphylococci were significantly more common among patients with bacteremia due to staphylococci with heteroresistance to vancomycin; these patients had an overall mortality of 44.4%. The use of vancomycin and admission to the intensive care unit were independently significant risk factors on multivariate analysis. Vancomycin heteroresistance is inducible by salt and β-lactams. Indiscriminate sequential use of β-lactams and glycopeptides may facilitate the emergence of glycopeptide resistance.en_HK
dc.format.extent712022 bytes-
dc.format.extent30720 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/msword-
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/cid/en_HK
dc.relation.ispartofClinical Infectious Diseasesen_HK
dc.rightsClinical Infectious Diseases. Copyright © University of Chicago Press.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshBacteremia - drug therapy - etiology - mortalityen_HK
dc.subject.meshMethicillin resistanceen_HK
dc.subject.meshStaphylococcus - drug effectsen_HK
dc.subject.meshVancomycin resistanceen_HK
dc.subject.meshRisk factorsen_HK
dc.titleBacteremia caused by staphylococci with inducible vancomycin heteroresistanceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1058-4838&volume=29&issue=4&spage=760&epage=767&date=1999&atitle=Bacteremia+caused+by+staphylococci+with+inducible+vancomycin+heteroresistanceen_HK
dc.identifier.emailWong, SSY:samsonsy@hkucc.hku.hken_HK
dc.identifier.emailHo, PL:plho@hkucc.hku.hken_HK
dc.identifier.emailWoo, PCY:pcywoo@hkucc.hku.hken_HK
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_HK
dc.identifier.authorityWong, SSY=rp00395en_HK
dc.identifier.authorityHo, PL=rp00406en_HK
dc.identifier.authorityWoo, PCY=rp00430en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid10589883-
dc.identifier.scopuseid_2-s2.0-0033509736en_HK
dc.identifier.hkuros50552-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033509736&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue4en_HK
dc.identifier.spage760en_HK
dc.identifier.epage767en_HK
dc.identifier.isiWOS:000083289500010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWong, SSY=13310021400en_HK
dc.identifier.scopusauthoridHo, PL=7402211363en_HK
dc.identifier.scopusauthoridWoo, PCY=7201801340en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK

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