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Article: Antigenic cross-reactivity between severe acute respiratory syndrome-associated coronavirus and human coronaviruses 229E and OC43

TitleAntigenic cross-reactivity between severe acute respiratory syndrome-associated coronavirus and human coronaviruses 229E and OC43
Authors
Issue Date2005
PublisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
Citation
Journal Of Infectious Diseases, 2005, v. 191 n. 12, p. 2033-2037 How to Cite?
AbstractCross-reactivity between antibodies to different human coronaviruses (HCoVs) has not been systematically studied. By use of Western blot analysis, indirect immunofluorescence assay (IFA), and enzyme-linked immunosorbent assay (ELISA), antigenic cross-reactivity between severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) and 2 HCoVs (229E and OC43) was demonstrated in immunized animals and human serum. In 5 of 11 and 10 of 11 patients with SARS, paired serum samples showed a ≥4-fold increase in antibody titers against HCoV-229E and HCoV-OC43, respectively, by IFA. Overall, serum samples from convalescent patients who had SARS had a 1-way cross-reactivity with the 2 known HCoVs. Antigens of SARS-CoV and HCoV-OC43 were more cross-reactive than were those of SARS-CoV and HCoV-229E. © 2005 by the Infectious Diseases Society of America. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/43117
ISSN
2015 Impact Factor: 6.344
2015 SCImago Journal Rankings: 4.000
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChe, XYen_HK
dc.contributor.authorQiu, LWen_HK
dc.contributor.authorLiao, ZYen_HK
dc.contributor.authorWang, YDen_HK
dc.contributor.authorWen, Ken_HK
dc.contributor.authorPan, YXen_HK
dc.contributor.authorHao, Wen_HK
dc.contributor.authorMei, YBen_HK
dc.contributor.authorCheng, VCCen_HK
dc.contributor.authorYuen, KYen_HK
dc.date.accessioned2007-03-23T04:39:16Z-
dc.date.available2007-03-23T04:39:16Z-
dc.date.issued2005en_HK
dc.identifier.citationJournal Of Infectious Diseases, 2005, v. 191 n. 12, p. 2033-2037en_HK
dc.identifier.issn0022-1899en_HK
dc.identifier.urihttp://hdl.handle.net/10722/43117-
dc.description.abstractCross-reactivity between antibodies to different human coronaviruses (HCoVs) has not been systematically studied. By use of Western blot analysis, indirect immunofluorescence assay (IFA), and enzyme-linked immunosorbent assay (ELISA), antigenic cross-reactivity between severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) and 2 HCoVs (229E and OC43) was demonstrated in immunized animals and human serum. In 5 of 11 and 10 of 11 patients with SARS, paired serum samples showed a ≥4-fold increase in antibody titers against HCoV-229E and HCoV-OC43, respectively, by IFA. Overall, serum samples from convalescent patients who had SARS had a 1-way cross-reactivity with the 2 known HCoVs. Antigens of SARS-CoV and HCoV-OC43 were more cross-reactive than were those of SARS-CoV and HCoV-229E. © 2005 by the Infectious Diseases Society of America. All rights reserved.en_HK
dc.format.extent474921 bytes-
dc.format.extent30720 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/msword-
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org en_HK
dc.relation.ispartofJournal of Infectious Diseasesen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsJournal of Infectious Diseases. Copyright © University of Chicago Press.en_HK
dc.subject.meshAntigens, viral - blooden_HK
dc.subject.meshCoronavirus 229e, human - immunologyen_HK
dc.subject.meshCoronavirus oc43, human - immunologyen_HK
dc.subject.meshSars virus - immunologyen_HK
dc.subject.meshAntibodies, viral - blooden_HK
dc.titleAntigenic cross-reactivity between severe acute respiratory syndrome-associated coronavirus and human coronaviruses 229E and OC43en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-1899&volume=191&issue=12&spage=2033&epage=2037&date=2005&atitle=Antigenic+cross-reactivity+between+severe+acute+respiratory+syndrome-associated+coronavirus+and+human+coronaviruses+229E+and+OC43en_HK
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1086/430355en_HK
dc.identifier.pmid15897988en_HK
dc.identifier.scopuseid_2-s2.0-20444399476en_HK
dc.identifier.hkuros100344-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-20444399476&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume191en_HK
dc.identifier.issue12en_HK
dc.identifier.spage2033en_HK
dc.identifier.epage2037en_HK
dc.identifier.isiWOS:000229203900006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChe, XY=7005743182en_HK
dc.identifier.scopusauthoridQiu, LW=8719102700en_HK
dc.identifier.scopusauthoridLiao, ZY=7203032864en_HK
dc.identifier.scopusauthoridWang, YD=9638471800en_HK
dc.identifier.scopusauthoridWen, K=8231190100en_HK
dc.identifier.scopusauthoridPan, YX=35765899800en_HK
dc.identifier.scopusauthoridHao, W=7101686587en_HK
dc.identifier.scopusauthoridMei, YB=8231190400en_HK
dc.identifier.scopusauthoridCheng, VCC=23670479400en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK

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