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Article: Diagnostic cues for natural killer cell lymphoma: Primary nodal presentation and the role of in situ hybridisation for Epstein-Barr virus encoded early small RNA in detecting occult bone marrow involvement

TitleDiagnostic cues for natural killer cell lymphoma: Primary nodal presentation and the role of in situ hybridisation for Epstein-Barr virus encoded early small RNA in detecting occult bone marrow involvement
Authors
Chim, CSMa, ESKLoong, FKwong, YL
Issue Date2005
PublisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/
Citation
Journal Of Clinical Pathology, 2005, v. 58 n. 4, p. 443-445 How to Cite?
DOI: http://dx.doi.org/10.1136/jcp.2004.022608
AbstractNatural killer (NK) cell lymphomas are rare, and atypical features might lead to diagnostic pitfalls. This report describes an unusual patient in whom lymphoma occurred initially as isolated lymph node involvement, an exceptional presentation of an almost exclusively extranodal disease. Furthermore, during the terminal haemophagocytosis in the bone marrow, lymphoma cells lost the expression of the NK cell marker, CD56, making the histopathological diagnosis of bone marrow involvement difficult. This was resolved by in situ hybridisation for Epstein-Barr virus encoded small RNA, which detected occult bone marrow infiltration.
Persistent Identifierhttp://hdl.handle.net/10722/43114
ISSN
0021-9746
2023 Impact Factor: 2.5
2023 SCImago Journal Rankings: 0.934
PubMed Central ID
PMC1770628
ISI Accession Number ID
WOS:000227872000026
References
References in Scopus

 

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dc.contributor.authorChim, CSen_HK
dc.contributor.authorMa, ESKen_HK
dc.contributor.authorLoong, Fen_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2007-03-23T04:39:09Z-
dc.date.available2007-03-23T04:39:09Z-
dc.date.issued2005en_HK
dc.identifier.citationJournal Of Clinical Pathology, 2005, v. 58 n. 4, p. 443-445en_HK
dc.identifier.issn0021-9746en_HK
dc.identifier.urihttp://hdl.handle.net/10722/43114-
dc.description.abstractNatural killer (NK) cell lymphomas are rare, and atypical features might lead to diagnostic pitfalls. This report describes an unusual patient in whom lymphoma occurred initially as isolated lymph node involvement, an exceptional presentation of an almost exclusively extranodal disease. Furthermore, during the terminal haemophagocytosis in the bone marrow, lymphoma cells lost the expression of the NK cell marker, CD56, making the histopathological diagnosis of bone marrow involvement difficult. This was resolved by in situ hybridisation for Epstein-Barr virus encoded small RNA, which detected occult bone marrow infiltration.en_HK
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dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/en_HK
dc.relation.ispartofJournal of Clinical Pathologyen_HK
dc.rightsJournal of clinical pathology. Copyright © B M J Publishing Group.en_HK
dc.subject.meshBone marrow neoplasms - immunology - pathologyen_HK
dc.subject.meshHerpesvirus 4, human - geneticsen_HK
dc.subject.meshKiller cells, natural - immunology - pathologyen_HK
dc.subject.meshLymphoma - diagnosis - immunology - pathologyen_HK
dc.subject.meshRna, viral - analysisen_HK
dc.titleDiagnostic cues for natural killer cell lymphoma: Primary nodal presentation and the role of in situ hybridisation for Epstein-Barr virus encoded early small RNA in detecting occult bone marrow involvementen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9746&volume=58&issue=4&spage=443&epage=445&date=2005&atitle=Diagnostic+cues+for+natural+killer+cell+lymphoma:+primary+nodal+presentation+and+the+role+of+in+situ+hybridisation+for+Epstein-Barr+virus+encoded+early+small+RNA+in+detecting+occult+bone+marrow+involvementen_HK
dc.identifier.emailChim, CS:jcschim@hku.hken_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityChim, CS=rp00408en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1136/jcp.2004.022608en_HK
dc.identifier.pmid15790718-
dc.identifier.pmcidPMC1770628-
dc.identifier.scopuseid_2-s2.0-17144417380en_HK
dc.identifier.hkuros99014-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-17144417380&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume58en_HK
dc.identifier.issue4en_HK
dc.identifier.spage443en_HK
dc.identifier.epage445en_HK
dc.identifier.isiWOS:000227872000026-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChim, CS=7004597253en_HK
dc.identifier.scopusauthoridMa, ESK=7202039934en_HK
dc.identifier.scopusauthoridLoong, F=6602794154en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.issnl0021-9746-

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