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Article: Histogenesis of human colorectal adenomas and hyperplastic polyps: The role of cell proliferation and crypt fission

TitleHistogenesis of human colorectal adenomas and hyperplastic polyps: The role of cell proliferation and crypt fission
Authors
Issue Date2002
PublisherBMJ Publishing Group. The Journal's web site is located at http://gut.bmjjournals.com/
Citation
Gut, 2002, v. 50 n. 2, p. 212-217 How to Cite?
AbstractBackground: The histogenesis of human colorectal hyperplastic polyps and colorectal adenomas is poorly understood even now. Method: Human colorectal adenomas, hyperplastic polyps, and normal colorectal mucosae (patients with familial adenomatous polyposis and hereditary non-polyposis colorectal carcinoma were excluded) were obtained during colonoscopy and microdissected into individual crypts. Morphology, cell proliferation characteristics, and fission indices of crypts isolated from these lesions were then studied. Results: Crypts isolated from colorectal adenomas and colorectal hyperplastic polyps were significantly larger (p<0.001) than crypts from normal colorectal mucosae. Crypt fission was an uncommon event in normal colonic mucosae but common in crypts isolated from adenomas and hyperplastic polyps (p<0.001). Analysis of the distribution of mitoses suggested an upward expansion of the proliferation compartment in adenomas to the surface of the crypt with no reversal of proliferating cell distribution, as has previously been described. Conclusions: Sporadic human colorectal adenomas and hyperplastic polyps grow by the process of crypt fission. Expansion of the proliferative compartment was demonstrated in crypts from adenomas, consistent with deregulation of cell cycle control.
Persistent Identifierhttp://hdl.handle.net/10722/43097
ISSN
2015 Impact Factor: 14.921
2015 SCImago Journal Rankings: 6.474
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, WMen_HK
dc.contributor.authorMandir, Nen_HK
dc.contributor.authorGoodlad, RAen_HK
dc.contributor.authorWong, BCYen_HK
dc.contributor.authorGarcia, SBen_HK
dc.contributor.authorLam, SKen_HK
dc.contributor.authorWright, NAen_HK
dc.date.accessioned2007-03-23T04:38:47Z-
dc.date.available2007-03-23T04:38:47Z-
dc.date.issued2002en_HK
dc.identifier.citationGut, 2002, v. 50 n. 2, p. 212-217en_HK
dc.identifier.issn0017-5749en_HK
dc.identifier.urihttp://hdl.handle.net/10722/43097-
dc.description.abstractBackground: The histogenesis of human colorectal hyperplastic polyps and colorectal adenomas is poorly understood even now. Method: Human colorectal adenomas, hyperplastic polyps, and normal colorectal mucosae (patients with familial adenomatous polyposis and hereditary non-polyposis colorectal carcinoma were excluded) were obtained during colonoscopy and microdissected into individual crypts. Morphology, cell proliferation characteristics, and fission indices of crypts isolated from these lesions were then studied. Results: Crypts isolated from colorectal adenomas and colorectal hyperplastic polyps were significantly larger (p<0.001) than crypts from normal colorectal mucosae. Crypt fission was an uncommon event in normal colonic mucosae but common in crypts isolated from adenomas and hyperplastic polyps (p<0.001). Analysis of the distribution of mitoses suggested an upward expansion of the proliferation compartment in adenomas to the surface of the crypt with no reversal of proliferating cell distribution, as has previously been described. Conclusions: Sporadic human colorectal adenomas and hyperplastic polyps grow by the process of crypt fission. Expansion of the proliferative compartment was demonstrated in crypts from adenomas, consistent with deregulation of cell cycle control.en_HK
dc.format.extent282903 bytes-
dc.format.extent28672 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/msword-
dc.languageengen_HK
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://gut.bmjjournals.com/en_HK
dc.relation.ispartofGuten_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsGut. Copyright © B M J Publishing Group.en_HK
dc.subject.meshAdenoma - pathologyen_HK
dc.subject.meshColorectal neoplasms - pathologyen_HK
dc.subject.meshIntestinal polyps - pathologyen_HK
dc.subject.meshRectal neoplasms - pathologyen_HK
dc.subject.meshImmunohistochemistry - methodsen_HK
dc.titleHistogenesis of human colorectal adenomas and hyperplastic polyps: The role of cell proliferation and crypt fissionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0017-5749&volume=50&issue=2&spage=212&epage=217&date=2002&atitle=Histogenesis+of+human+colorectal+adenomas+and+hyperplastic+polyps:+the+role+of+cell+proliferation+and+crypt+fissionen_HK
dc.identifier.emailWong, BCY:bcywong@hku.hken_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1136/gut.0500212..en_HK
dc.identifier.pmid11788562-
dc.identifier.pmcidPMC1773120-
dc.identifier.scopuseid_2-s2.0-0036150962en_HK
dc.identifier.hkuros72110-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036150962&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume50en_HK
dc.identifier.issue2en_HK
dc.identifier.spage212en_HK
dc.identifier.epage217en_HK
dc.identifier.isiWOS:000173416800015-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWong, WM=36847934700en_HK
dc.identifier.scopusauthoridMandir, N=6602820690en_HK
dc.identifier.scopusauthoridGoodlad, RA=35459498300en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK
dc.identifier.scopusauthoridGarcia, SB=7201561208en_HK
dc.identifier.scopusauthoridLam, SK=7402279473en_HK
dc.identifier.scopusauthoridWright, NA=7201531909en_HK

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