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Article: Immunorestitution disease involving the innate and adaptive response

TitleImmunorestitution disease involving the innate and adaptive response
Authors
Issue Date2000
PublisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/cid/
Citation
Clinical Infectious Diseases, 2000, v. 30 n. 6, p. 882-892 How to Cite?
AbstractImmunorestitution disease (IRD) is defined as an acute symptomatic or paradoxical deterioration of a (presumably) preexisting infection that is temporally related to the recovery of the immune system. We report the temporal sequence of events that led to IRD caused by Pneumocystis carinii and Aspergillus terreus in 2 human immunodeficiency virus (HIV)-negative patients soon after the recovery of adaptive and innate immunity, respectively, and we review episodes noted in the English-language literature that fit the definition of IRD (109 episodes in 107 patients). The median time from the recovery of neutrophil counts or termination of steroid therapy to the development of IRD was 8 days in cases of pulmonary aspergillosis (23 episodes) and hepatosplenic candidiasis (8) and 21 days for viral diseases such as hepatitis B (24) and viral pneumonitis (6). For IRD due to mycobacteriosis (27 episodes) and cryptococcosis (4) in HIV-positive patients, the median interval between the initiation of highly active antiretroviral therapy (HAART) and the onset of IRD was 11 days; for viral infections, including those due to cytomegalovirus (14), hepatitis B virus (1), and hepatitis C virus (2), the median interval was 42 days. As an emerging clinical entity, IRD merits further study to optimize treatment of immunosuppressed patients.
Persistent Identifierhttp://hdl.handle.net/10722/43094
ISSN
2015 Impact Factor: 8.736
2015 SCImago Journal Rankings: 4.742
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheng, VCCen_HK
dc.contributor.authorYuen, KYen_HK
dc.contributor.authorChan, WMen_HK
dc.contributor.authorWong, SSYen_HK
dc.contributor.authorMa, ESKen_HK
dc.contributor.authorChan, RMTen_HK
dc.date.accessioned2007-03-23T04:38:43Z-
dc.date.available2007-03-23T04:38:43Z-
dc.date.issued2000en_HK
dc.identifier.citationClinical Infectious Diseases, 2000, v. 30 n. 6, p. 882-892en_HK
dc.identifier.issn1058-4838en_HK
dc.identifier.urihttp://hdl.handle.net/10722/43094-
dc.description.abstractImmunorestitution disease (IRD) is defined as an acute symptomatic or paradoxical deterioration of a (presumably) preexisting infection that is temporally related to the recovery of the immune system. We report the temporal sequence of events that led to IRD caused by Pneumocystis carinii and Aspergillus terreus in 2 human immunodeficiency virus (HIV)-negative patients soon after the recovery of adaptive and innate immunity, respectively, and we review episodes noted in the English-language literature that fit the definition of IRD (109 episodes in 107 patients). The median time from the recovery of neutrophil counts or termination of steroid therapy to the development of IRD was 8 days in cases of pulmonary aspergillosis (23 episodes) and hepatosplenic candidiasis (8) and 21 days for viral diseases such as hepatitis B (24) and viral pneumonitis (6). For IRD due to mycobacteriosis (27 episodes) and cryptococcosis (4) in HIV-positive patients, the median interval between the initiation of highly active antiretroviral therapy (HAART) and the onset of IRD was 11 days; for viral infections, including those due to cytomegalovirus (14), hepatitis B virus (1), and hepatitis C virus (2), the median interval was 42 days. As an emerging clinical entity, IRD merits further study to optimize treatment of immunosuppressed patients.en_HK
dc.format.extent125710 bytes-
dc.format.extent30720 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/msword-
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/cid/en_HK
dc.relation.ispartofClinical Infectious Diseasesen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsClinical Infectious Diseases. Copyright © University of Chicago Press.en_HK
dc.subject.meshAspergillosis - immunology - microbiologyen_HK
dc.subject.meshImmunity, activeen_HK
dc.subject.meshImmunity, naturalen_HK
dc.subject.meshLung diseases, fungal - immunology - microbiologyen_HK
dc.subject.meshPneumocystis - immunologyen_HK
dc.titleImmunorestitution disease involving the innate and adaptive responseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1058-4838&volume=30&issue=6&spage=882&epage=892&date=2000&atitle=Immunorestitution+Disease+Involving+the+Innate+and+Adaptive+Responseen_HK
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_HK
dc.identifier.emailWong, SSY:samsonsy@hkucc.hku.hken_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.identifier.authorityWong, SSY=rp00395en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1086/313809en_HK
dc.identifier.pmid10880300-
dc.identifier.scopuseid_2-s2.0-0034463167en_HK
dc.identifier.hkuros54349-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034463167&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume30en_HK
dc.identifier.issue6en_HK
dc.identifier.spage882en_HK
dc.identifier.epage892en_HK
dc.identifier.isiWOS:000088525400009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheng, VCC=23670479400en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.scopusauthoridChan, WM=36338834700en_HK
dc.identifier.scopusauthoridWong, SSY=13310021400en_HK
dc.identifier.scopusauthoridMa, ESK=24725277400en_HK
dc.identifier.scopusauthoridChan, RMT=7403110774en_HK

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