File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: The role of polyamines in gastric mucus synthesis inhibited by cigarette smoke or its extract

TitleThe role of polyamines in gastric mucus synthesis inhibited by cigarette smoke or its extract
Authors
KeywordsMucus
Ornithine decarbozylase
Cigarette smoking
Ulcers
Issue Date2000
PublisherB M J Publishing Group. The Journal's web site is located at http://gut.bmjjournals.com/
Citation
Gut, 2000, v. 47 n. 2, p. 170-177 How to Cite?
AbstractBackground-Cigarette smoking was shown to delay gastric ulcer healing and reduce synthesis of mucus, which is important for gastric ulcer protection and healing. Polyamines are important in these processes. Aims-To study the effects of cigarette smoking on the synthesis of mucus and to investigate if such an effect is acting by interference with the polyamine pathway. Methods-Gastric mucosal ornithine decarboxylase activity, mucous secreting layer thickness, and ulcer size were determined after different concentrations of cigarette smoke exposure (0, 2, or 4%) in intact animals and animals with ulcers. Synthesis of mucus and ornithine decarboxylase activity and mRNA expression were also assessed in cigarette smoke extract treated MKN-28 cells. Results-Exposure to cigarette smoke significantly reduced the thickness of the mucous secreting layer and gastric mucosal ornithine decarboxylase activity in animals with or without ulcers. Spermidine not only reversed inhibition of mucus synthesis in both intact and ulcer bearing animals but also reversed the delay in ulcer healing. Cigarette smoke extract significantly reduced mucus synthesis and ornithine decarboxylase activity but not its mRNA expression in MKN-28 cells. The reduction in mucus synthesis was restored by spermidine. Conclusions-Cigarette smoke and its extract repress mucus synthesis in vivo and in vitro, respectively. Reduction of ornithine decarboxylase activity in gastric mucosa is closely associated with this effect.
Persistent Identifierhttp://hdl.handle.net/10722/43092
ISSN
2015 Impact Factor: 14.921
2015 SCImago Journal Rankings: 6.474
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMa, Len_HK
dc.contributor.authorWang, WPen_HK
dc.contributor.authorChow, JYCen_HK
dc.contributor.authorLam, SKen_HK
dc.contributor.authorCho, CHen_HK
dc.date.accessioned2007-03-23T04:38:41Z-
dc.date.available2007-03-23T04:38:41Z-
dc.date.issued2000en_HK
dc.identifier.citationGut, 2000, v. 47 n. 2, p. 170-177en_HK
dc.identifier.issn0017-5749en_HK
dc.identifier.urihttp://hdl.handle.net/10722/43092-
dc.description.abstractBackground-Cigarette smoking was shown to delay gastric ulcer healing and reduce synthesis of mucus, which is important for gastric ulcer protection and healing. Polyamines are important in these processes. Aims-To study the effects of cigarette smoking on the synthesis of mucus and to investigate if such an effect is acting by interference with the polyamine pathway. Methods-Gastric mucosal ornithine decarboxylase activity, mucous secreting layer thickness, and ulcer size were determined after different concentrations of cigarette smoke exposure (0, 2, or 4%) in intact animals and animals with ulcers. Synthesis of mucus and ornithine decarboxylase activity and mRNA expression were also assessed in cigarette smoke extract treated MKN-28 cells. Results-Exposure to cigarette smoke significantly reduced the thickness of the mucous secreting layer and gastric mucosal ornithine decarboxylase activity in animals with or without ulcers. Spermidine not only reversed inhibition of mucus synthesis in both intact and ulcer bearing animals but also reversed the delay in ulcer healing. Cigarette smoke extract significantly reduced mucus synthesis and ornithine decarboxylase activity but not its mRNA expression in MKN-28 cells. The reduction in mucus synthesis was restored by spermidine. Conclusions-Cigarette smoke and its extract repress mucus synthesis in vivo and in vitro, respectively. Reduction of ornithine decarboxylase activity in gastric mucosa is closely associated with this effect.en_HK
dc.format.extent1738999 bytes-
dc.format.extent27648 bytes-
dc.format.extent79456 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/msword-
dc.format.mimetypeapplication/pdf-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://gut.bmjjournals.com/en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsGut. Copyright © B M J Publishing Group.en_HK
dc.subjectMucusen_HK
dc.subjectOrnithine decarbozylaseen_HK
dc.subjectCigarette smokingen_HK
dc.subjectUlcersen_HK
dc.titleThe role of polyamines in gastric mucus synthesis inhibited by cigarette smoke or its extracten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0017-5749&volume=47&issue=2&spage=170&epage=177&date=2000&atitle=The+role+of+polyamines+in+gastric+mucus+synthesis+inhibited+by+cigarette+smoke+or+its+extracten_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1136/gut.47.2.170-
dc.identifier.pmid10896906-
dc.identifier.scopuseid_2-s2.0-0033944530-
dc.identifier.hkuros51691-
dc.identifier.isiWOS:000088380700007-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats