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Article: Association of pure red cell aplasia with T large granular lymphocyte leukaemia

TitleAssociation of pure red cell aplasia with T large granular lymphocyte leukaemia
Authors
KeywordsLarge granular lymphocyte leukaemia
Pure red cell aplasia
Issue Date1998
PublisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/
Citation
Journal Of Clinical Pathology, 1998, v. 51 n. 9, p. 672-675 How to Cite?
AbstractAim - To define the relation between T large granular lymphocyte (T- LGL) leukaemia and pure red cell aplasia in Chinese patients. Methods - Patients with T-LGL leukaemia were identified from a consecutive series of Chinese patients with chronic lymphoproliferative disorders. The diagnosis of T-LGL leukaemia was based on typical morphological and immunophenotypical features, and confirmed by the detection of clonal T cell receptor gene rearrangement. The clinicopathological features, response to treatment, and long term follow up were also examined. Results - Five patients were identified as having T-LGL leukaemia from a consecutive series of 33 Chinese patients with chronic lymphoproliferative disorders. The median follow up time was 45 months. An obvious lymphocytosis was present in only two cases, although an increase in large granular lymphocytes in the peripheral blood was found in four. In one case, the LGL count was within the normal range. Epstein-Barr virus encoded early nuclear RNA was negative in all the cases. There was no evidence of rheumatoid arthritis, and none of the patients presented with recurrent infections. On follow up, pure red cell aplasia occurred at some stage of the disease in all the patients. This responded to treatment with cyclosporin A in two and with antithymocyte globulin in one. Two patients remained transfusion dependent. Conclusions - In contrast to Western patients, Chinese patients with T-LGL leukaemia do not appear to suffer from rheumatoid arthritis and recurrent infections, but pure red cell aplasia is a major cause of morbidity in this ethnic group.
Persistent Identifierhttp://hdl.handle.net/10722/43087
ISSN
2015 Impact Factor: 2.912
2015 SCImago Journal Rankings: 1.260
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKwong, YLen_HK
dc.contributor.authorWong, KFen_HK
dc.date.accessioned2007-03-23T04:38:34Z-
dc.date.available2007-03-23T04:38:34Z-
dc.date.issued1998en_HK
dc.identifier.citationJournal Of Clinical Pathology, 1998, v. 51 n. 9, p. 672-675en_HK
dc.identifier.issn0021-9746en_HK
dc.identifier.urihttp://hdl.handle.net/10722/43087-
dc.description.abstractAim - To define the relation between T large granular lymphocyte (T- LGL) leukaemia and pure red cell aplasia in Chinese patients. Methods - Patients with T-LGL leukaemia were identified from a consecutive series of Chinese patients with chronic lymphoproliferative disorders. The diagnosis of T-LGL leukaemia was based on typical morphological and immunophenotypical features, and confirmed by the detection of clonal T cell receptor gene rearrangement. The clinicopathological features, response to treatment, and long term follow up were also examined. Results - Five patients were identified as having T-LGL leukaemia from a consecutive series of 33 Chinese patients with chronic lymphoproliferative disorders. The median follow up time was 45 months. An obvious lymphocytosis was present in only two cases, although an increase in large granular lymphocytes in the peripheral blood was found in four. In one case, the LGL count was within the normal range. Epstein-Barr virus encoded early nuclear RNA was negative in all the cases. There was no evidence of rheumatoid arthritis, and none of the patients presented with recurrent infections. On follow up, pure red cell aplasia occurred at some stage of the disease in all the patients. This responded to treatment with cyclosporin A in two and with antithymocyte globulin in one. Two patients remained transfusion dependent. Conclusions - In contrast to Western patients, Chinese patients with T-LGL leukaemia do not appear to suffer from rheumatoid arthritis and recurrent infections, but pure red cell aplasia is a major cause of morbidity in this ethnic group.en_HK
dc.format.extent191500 bytes-
dc.format.extent26112 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/msword-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/en_HK
dc.relation.ispartofJournal of Clinical Pathologyen_HK
dc.rightsJournal of Clinical Pathology. Copyright © B M J Publishing Group.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectLarge granular lymphocyte leukaemiaen_HK
dc.subjectPure red cell aplasiaen_HK
dc.subject.meshGene rearrangement, gamma-chain t-cell antigen receptoren_HK
dc.subject.meshLeukemia, t-cell - complications - ethnology - pathologyen_HK
dc.subject.meshPolymerase chain reactionen_HK
dc.subject.meshRed-cell aplasia, pure - etiology - therapyen_HK
dc.subject.meshTreatment outcomeen_HK
dc.titleAssociation of pure red cell aplasia with T large granular lymphocyte leukaemiaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9746&volume=51&issue=9&spage=672&epage=675&date=1998&atitle=Association+of+pure+red+cell+aplasia+with+T+large+granular+lymphocyte+leukaemiaen_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid9930071-
dc.identifier.pmcidPMC500904-
dc.identifier.scopuseid_2-s2.0-0031715912en_HK
dc.identifier.hkuros41948-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031715912&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume51en_HK
dc.identifier.issue9en_HK
dc.identifier.spage672en_HK
dc.identifier.epage675en_HK
dc.identifier.isiWOS:000075907600009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.scopusauthoridWong, KF=7404759860en_HK

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