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Article: Stage-specific manifestation of mold infections in bone marrow transplant recipients: Risk factors and clinical significance of positive concentrated smears

TitleStage-specific manifestation of mold infections in bone marrow transplant recipients: Risk factors and clinical significance of positive concentrated smears
Authors
Issue Date1997
PublisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/cid/
Citation
Clinical Infectious Diseases, 1997, v. 25 n. 1, p. 37-42 How to Cite?
AbstractPotassium hydroxide-concentrated smears, prepared from sedimented remains of clinical specimens, were used to distinguish between mold infection and exogenous contamination in fungal culture-positive specimens. This method was applied in the study of 3,857 clinical specimens from 230 bone marrow transplant recipients who were followed up prospectively for infectious complications. Concentrated smears of only 86 (from 21 infected patients) of 149 fungal culture-positive specimens were positive for hyphae; 82 of the strains were Aspergillus species. Concentrated smears of the remaining 63 fungal culture-positive specimens were negative; the strains identified by culture were considered as exogenous contaminants (87% of which were Penicillium species). A stage-specific manifestation of mold infection was observed: 67% of mold infections occurred during acute graft-vs.-host disease (GVHD) a median of 47 days after transplantation, whereas 9% of mold infections occurred as rapidly fatal invasive disease before engraftment. Overall, of the 21 patients with mold infection, 17 (81%) had invasive mold disease, and four (19%) had mold colonization of airways secondary to chronic GVHD after day 100. The significant risk factors for mold infection were total-body irradiation and grade 2-4 acute GVHD. Because of our high mortality rate (82%), the consideration of antimold prophylaxis for such patients may be warranted.
Persistent Identifierhttp://hdl.handle.net/10722/43081
ISSN
2015 Impact Factor: 8.736
2015 SCImago Journal Rankings: 4.742
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYuen, KYen_HK
dc.contributor.authorWoo, PCYen_HK
dc.contributor.authorIp, MSMen_HK
dc.contributor.authorLiang, RHSen_HK
dc.contributor.authorChiu, EKWen_HK
dc.contributor.authorSiau, Hen_HK
dc.contributor.authorHo P, Len_HK
dc.contributor.authorChen, FFEen_HK
dc.contributor.authorChan, TKen_HK
dc.date.accessioned2007-03-23T04:38:26Z-
dc.date.available2007-03-23T04:38:26Z-
dc.date.issued1997en_HK
dc.identifier.citationClinical Infectious Diseases, 1997, v. 25 n. 1, p. 37-42en_HK
dc.identifier.issn1058-4838en_HK
dc.identifier.urihttp://hdl.handle.net/10722/43081-
dc.description.abstractPotassium hydroxide-concentrated smears, prepared from sedimented remains of clinical specimens, were used to distinguish between mold infection and exogenous contamination in fungal culture-positive specimens. This method was applied in the study of 3,857 clinical specimens from 230 bone marrow transplant recipients who were followed up prospectively for infectious complications. Concentrated smears of only 86 (from 21 infected patients) of 149 fungal culture-positive specimens were positive for hyphae; 82 of the strains were Aspergillus species. Concentrated smears of the remaining 63 fungal culture-positive specimens were negative; the strains identified by culture were considered as exogenous contaminants (87% of which were Penicillium species). A stage-specific manifestation of mold infection was observed: 67% of mold infections occurred during acute graft-vs.-host disease (GVHD) a median of 47 days after transplantation, whereas 9% of mold infections occurred as rapidly fatal invasive disease before engraftment. Overall, of the 21 patients with mold infection, 17 (81%) had invasive mold disease, and four (19%) had mold colonization of airways secondary to chronic GVHD after day 100. The significant risk factors for mold infection were total-body irradiation and grade 2-4 acute GVHD. Because of our high mortality rate (82%), the consideration of antimold prophylaxis for such patients may be warranted.en_HK
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dc.format.extent3198 bytes-
dc.format.extent2603 bytes-
dc.format.mimetypeapplication/pdf-
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dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/cid/en_HK
dc.relation.ispartofClinical Infectious Diseasesen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsClinical Infectious Diseases. Copyright © University of Chicago Press.en_HK
dc.subject.meshAspergillus - isolation & purificationen_HK
dc.subject.meshBone marrow transplantation - adverse effectsen_HK
dc.subject.meshFusariumen_HK
dc.subject.meshChild, preschoolen_HK
dc.subject.meshProspective studiesen_HK
dc.titleStage-specific manifestation of mold infections in bone marrow transplant recipients: Risk factors and clinical significance of positive concentrated smearsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1058-4838&volume=25&issue=1&spage=37&epage=42&date=1997&atitle=Stage-specific+manifestation+of+mold+infections+in+bone+marrow+transplant+recipients:+risk+factors+and+clinical+significance+of+positive+concentrated+smearsen_HK
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_HK
dc.identifier.emailWoo, PCY:pcywoo@hkucc.hku.hken_HK
dc.identifier.emailIp, MSM:msmip@hku.hken_HK
dc.identifier.emailLiang, RHS:rliang@hku.hken_HK
dc.identifier.emailHo P, L:plho@hkucc.hku.hken_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.identifier.authorityWoo, PCY=rp00430en_HK
dc.identifier.authorityIp, MSM=rp00347en_HK
dc.identifier.authorityLiang, RHS=rp00345en_HK
dc.identifier.authorityHo P, L=rp00406en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid9243031-
dc.identifier.scopuseid_2-s2.0-0030744147en_HK
dc.identifier.hkuros33127-
dc.identifier.volume25en_HK
dc.identifier.issue1en_HK
dc.identifier.spage37en_HK
dc.identifier.epage42en_HK
dc.identifier.isiWOS:A1997XL36700009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.scopusauthoridWoo, PCY=7201801340en_HK
dc.identifier.scopusauthoridIp, MSM=7102423259en_HK
dc.identifier.scopusauthoridLiang, RHS=26643224900en_HK
dc.identifier.scopusauthoridChiu, EKW=24827833600en_HK
dc.identifier.scopusauthoridSiau, H=16751930400en_HK
dc.identifier.scopusauthoridHo P, L=7402211363en_HK
dc.identifier.scopusauthoridChen, FFE=25928259900en_HK
dc.identifier.scopusauthoridChan, TK=37076590700en_HK

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