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Article: Clinical profiles of chinese patients with diffuse panbronchiolitis
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TitleClinical profiles of chinese patients with diffuse panbronchiolitis
 
AuthorsTsang, KWT1
Ooi, CGC1
Ip, MSM1
Lam, WK1
Ngan, H1
Chan, EYT1
Hawkins, B1
Ho, CS1
Amitani, R2
Tanaka, E2
Itoh, H2
 
KeywordsChinese
Chronic bronchial sepsis
Diffuse panbronchiolitis
Macrolides
 
Issue Date1998
 
PublisherB M J Publishing Group. The Journal's web site is located at http://thorax.bmjjournals.com/
 
CitationThorax, 1998, v. 53 n. 4, p. 274-280 [How to Cite?]
 
AbstractBackground - Diffuse panbronchiolitis (DPB), characterised by progressive sinobronchial sepsis, is well characterised in Japanese subjects but not in other ethnic groups. The experience with DPB in seven Chinese patients is described and the clinical profiles compared with those of Japanese subjects. Methods - Seven Chinese patients (three women; mean (SD) age 48(18.6) years, all never smokers) who attended a teaching hospital centre and fulfilled the diagnostic criteria for DPB were assessed prospectively for clinical, radiological, lung function, microbiological, and other 'characteristic' laboratory parameters. Results - Lung function assessment showed a typical obstructive pattern (n = 5) and air trapping (n = 7). Typical bronchiolar infiltration by lymphocytes and plasma cells and accumulation of foamy macrophages in the intraluminal tissue were detected in open lung biopsy specimens (n = 2). Chest radiographs and high resolution computed tomographic scans revealed hyperinflation, diffuse nodules, bronchial thickening and dilatation, peripheral hypoattenuation, and bronchiolectasis. Radiological improvement, manifest as a reduction in nodular density and bronchial thickening, and persistence of other abnormalities such as air trapping were not accurately depicted by the classical Nakata or Akira classifications. The other 'characteristic' features such as HLA-B54, IgG subclass deficiency, raised GD4/CD8 T lymphocyte ratio, cold haemagglutinaemia, raised IgA, IgG, and rheumatoid factor were not present. Treatment with erythromycin led to excellent responses in symptoms, lung function indices, and the radiological picture. A review of the non-Japanese cases in the literature reveals that this absence of typical 'additional features' in DPB might also be applicable to non- Japanese patients. Conclusions - We report the only series of non-Japanese Mongoloid patients with well characterised DPB who had uncharacteristic investigation profiles. This experience should help other clinicians in the investigation and management of DPB in non-Japanese patients.
 
ISSN0040-6376
2013 Impact Factor: 8.562
 
PubMed Central IDPMC1745191
 
ISI Accession Number IDWOS:000073334300010
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorTsang, KWT
 
dc.contributor.authorOoi, CGC
 
dc.contributor.authorIp, MSM
 
dc.contributor.authorLam, WK
 
dc.contributor.authorNgan, H
 
dc.contributor.authorChan, EYT
 
dc.contributor.authorHawkins, B
 
dc.contributor.authorHo, CS
 
dc.contributor.authorAmitani, R
 
dc.contributor.authorTanaka, E
 
dc.contributor.authorItoh, H
 
dc.date.accessioned2007-03-23T04:29:33Z
 
dc.date.available2007-03-23T04:29:33Z
 
dc.date.issued1998
 
dc.description.abstractBackground - Diffuse panbronchiolitis (DPB), characterised by progressive sinobronchial sepsis, is well characterised in Japanese subjects but not in other ethnic groups. The experience with DPB in seven Chinese patients is described and the clinical profiles compared with those of Japanese subjects. Methods - Seven Chinese patients (three women; mean (SD) age 48(18.6) years, all never smokers) who attended a teaching hospital centre and fulfilled the diagnostic criteria for DPB were assessed prospectively for clinical, radiological, lung function, microbiological, and other 'characteristic' laboratory parameters. Results - Lung function assessment showed a typical obstructive pattern (n = 5) and air trapping (n = 7). Typical bronchiolar infiltration by lymphocytes and plasma cells and accumulation of foamy macrophages in the intraluminal tissue were detected in open lung biopsy specimens (n = 2). Chest radiographs and high resolution computed tomographic scans revealed hyperinflation, diffuse nodules, bronchial thickening and dilatation, peripheral hypoattenuation, and bronchiolectasis. Radiological improvement, manifest as a reduction in nodular density and bronchial thickening, and persistence of other abnormalities such as air trapping were not accurately depicted by the classical Nakata or Akira classifications. The other 'characteristic' features such as HLA-B54, IgG subclass deficiency, raised GD4/CD8 T lymphocyte ratio, cold haemagglutinaemia, raised IgA, IgG, and rheumatoid factor were not present. Treatment with erythromycin led to excellent responses in symptoms, lung function indices, and the radiological picture. A review of the non-Japanese cases in the literature reveals that this absence of typical 'additional features' in DPB might also be applicable to non- Japanese patients. Conclusions - We report the only series of non-Japanese Mongoloid patients with well characterised DPB who had uncharacteristic investigation profiles. This experience should help other clinicians in the investigation and management of DPB in non-Japanese patients.
 
dc.description.naturepublished_or_final_version
 
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dc.identifier.citationThorax, 1998, v. 53 n. 4, p. 274-280 [How to Cite?]
 
dc.identifier.epage280
 
dc.identifier.hkuros36078
 
dc.identifier.isiWOS:000073334300010
 
dc.identifier.issn0040-6376
2013 Impact Factor: 8.562
 
dc.identifier.issue4
 
dc.identifier.openurl
 
dc.identifier.pmcidPMC1745191
 
dc.identifier.pmid9741370
 
dc.identifier.scopuseid_2-s2.0-7144251170
 
dc.identifier.spage274
 
dc.identifier.urihttp://hdl.handle.net/10722/42673
 
dc.identifier.volume53
 
dc.languageeng
 
dc.publisherB M J Publishing Group. The Journal's web site is located at http://thorax.bmjjournals.com/
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofThorax
 
dc.relation.referencesReferences in Scopus
 
dc.rightsThorax. Copyright © B M J Publishing Group.
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshAnti-Bacterial Agents - therapeutic use
 
dc.subject.meshAsian Continental Ancestry Group
 
dc.subject.meshBronchiolitis - ethnology - physiopathology - radiography
 
dc.subject.meshChina
 
dc.subject.meshErythromycin - therapeutic use
 
dc.subjectChinese
 
dc.subjectChronic bronchial sepsis
 
dc.subjectDiffuse panbronchiolitis
 
dc.subjectMacrolides
 
dc.titleClinical profiles of chinese patients with diffuse panbronchiolitis
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Kyoto University