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Article: Clinical profiles of chinese patients with diffuse panbronchiolitis

TitleClinical profiles of chinese patients with diffuse panbronchiolitis
Authors
KeywordsChinese
Chronic bronchial sepsis
Diffuse panbronchiolitis
Macrolides
Issue Date1998
PublisherB M J Publishing Group. The Journal's web site is located at http://thorax.bmjjournals.com/
Citation
Thorax, 1998, v. 53 n. 4, p. 274-280 How to Cite?
AbstractBackground - Diffuse panbronchiolitis (DPB), characterised by progressive sinobronchial sepsis, is well characterised in Japanese subjects but not in other ethnic groups. The experience with DPB in seven Chinese patients is described and the clinical profiles compared with those of Japanese subjects. Methods - Seven Chinese patients (three women; mean (SD) age 48(18.6) years, all never smokers) who attended a teaching hospital centre and fulfilled the diagnostic criteria for DPB were assessed prospectively for clinical, radiological, lung function, microbiological, and other 'characteristic' laboratory parameters. Results - Lung function assessment showed a typical obstructive pattern (n = 5) and air trapping (n = 7). Typical bronchiolar infiltration by lymphocytes and plasma cells and accumulation of foamy macrophages in the intraluminal tissue were detected in open lung biopsy specimens (n = 2). Chest radiographs and high resolution computed tomographic scans revealed hyperinflation, diffuse nodules, bronchial thickening and dilatation, peripheral hypoattenuation, and bronchiolectasis. Radiological improvement, manifest as a reduction in nodular density and bronchial thickening, and persistence of other abnormalities such as air trapping were not accurately depicted by the classical Nakata or Akira classifications. The other 'characteristic' features such as HLA-B54, IgG subclass deficiency, raised GD4/CD8 T lymphocyte ratio, cold haemagglutinaemia, raised IgA, IgG, and rheumatoid factor were not present. Treatment with erythromycin led to excellent responses in symptoms, lung function indices, and the radiological picture. A review of the non-Japanese cases in the literature reveals that this absence of typical 'additional features' in DPB might also be applicable to non- Japanese patients. Conclusions - We report the only series of non-Japanese Mongoloid patients with well characterised DPB who had uncharacteristic investigation profiles. This experience should help other clinicians in the investigation and management of DPB in non-Japanese patients.
Persistent Identifierhttp://hdl.handle.net/10722/42673
ISSN
2014 Impact Factor: 8.290
2014 SCImago Journal Rankings: 3.142
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTsang, KWTen_HK
dc.contributor.authorOoi, CGCen_HK
dc.contributor.authorIp, MSMen_HK
dc.contributor.authorLam, WKen_HK
dc.contributor.authorNgan, Hen_HK
dc.contributor.authorChan, EYTen_HK
dc.contributor.authorHawkins, Ben_HK
dc.contributor.authorHo, CSen_HK
dc.contributor.authorAmitani, Ren_HK
dc.contributor.authorTanaka, Een_HK
dc.contributor.authorItoh, Hen_HK
dc.date.accessioned2007-03-23T04:29:33Z-
dc.date.available2007-03-23T04:29:33Z-
dc.date.issued1998en_HK
dc.identifier.citationThorax, 1998, v. 53 n. 4, p. 274-280en_HK
dc.identifier.issn0040-6376en_HK
dc.identifier.urihttp://hdl.handle.net/10722/42673-
dc.description.abstractBackground - Diffuse panbronchiolitis (DPB), characterised by progressive sinobronchial sepsis, is well characterised in Japanese subjects but not in other ethnic groups. The experience with DPB in seven Chinese patients is described and the clinical profiles compared with those of Japanese subjects. Methods - Seven Chinese patients (three women; mean (SD) age 48(18.6) years, all never smokers) who attended a teaching hospital centre and fulfilled the diagnostic criteria for DPB were assessed prospectively for clinical, radiological, lung function, microbiological, and other 'characteristic' laboratory parameters. Results - Lung function assessment showed a typical obstructive pattern (n = 5) and air trapping (n = 7). Typical bronchiolar infiltration by lymphocytes and plasma cells and accumulation of foamy macrophages in the intraluminal tissue were detected in open lung biopsy specimens (n = 2). Chest radiographs and high resolution computed tomographic scans revealed hyperinflation, diffuse nodules, bronchial thickening and dilatation, peripheral hypoattenuation, and bronchiolectasis. Radiological improvement, manifest as a reduction in nodular density and bronchial thickening, and persistence of other abnormalities such as air trapping were not accurately depicted by the classical Nakata or Akira classifications. The other 'characteristic' features such as HLA-B54, IgG subclass deficiency, raised GD4/CD8 T lymphocyte ratio, cold haemagglutinaemia, raised IgA, IgG, and rheumatoid factor were not present. Treatment with erythromycin led to excellent responses in symptoms, lung function indices, and the radiological picture. A review of the non-Japanese cases in the literature reveals that this absence of typical 'additional features' in DPB might also be applicable to non- Japanese patients. Conclusions - We report the only series of non-Japanese Mongoloid patients with well characterised DPB who had uncharacteristic investigation profiles. This experience should help other clinicians in the investigation and management of DPB in non-Japanese patients.en_HK
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dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://thorax.bmjjournals.com/en_HK
dc.relation.ispartofThoraxen_HK
dc.rightsThorax. Copyright © B M J Publishing Group.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectChineseen_HK
dc.subjectChronic bronchial sepsisen_HK
dc.subjectDiffuse panbronchiolitisen_HK
dc.subjectMacrolidesen_HK
dc.subject.meshAnti-Bacterial Agents - therapeutic use-
dc.subject.meshAsian Continental Ancestry Group-
dc.subject.meshBronchiolitis - ethnology - physiopathology - radiography-
dc.subject.meshChina-
dc.subject.meshErythromycin - therapeutic use-
dc.titleClinical profiles of chinese patients with diffuse panbronchiolitisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0040-6376&volume=53&issue=4&spage=274&epage=280&date=1998&atitle=The+clinical+profiles+of+Chinese+patients+with+diffuse+panbronchiolitisen_HK
dc.identifier.emailIp, MSM:msmip@hku.hken_HK
dc.identifier.authorityIp, MSM=rp00347en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid9741370en_HK
dc.identifier.pmcidPMC1745191-
dc.identifier.scopuseid_2-s2.0-7144251170en_HK
dc.identifier.hkuros36078-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-7144251170&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume53en_HK
dc.identifier.issue4en_HK
dc.identifier.spage274en_HK
dc.identifier.epage280en_HK
dc.identifier.isiWOS:000073334300010-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridTsang, KWT=7201555024en_HK
dc.identifier.scopusauthoridOoi, CGC=7007084909en_HK
dc.identifier.scopusauthoridIp, MSM=7102423259en_HK
dc.identifier.scopusauthoridLam, WK=7203021937en_HK
dc.identifier.scopusauthoridNgan, H=7102173824en_HK
dc.identifier.scopusauthoridChan, EYT=7401994013en_HK
dc.identifier.scopusauthoridHawkins, B=35944486200en_HK
dc.identifier.scopusauthoridHo, CS=36985962300en_HK
dc.identifier.scopusauthoridAmitani, R=7006768416en_HK
dc.identifier.scopusauthoridTanaka, E=7401815855en_HK
dc.identifier.scopusauthoridItoh, H=35402942000en_HK

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