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Article: Sonic hedgehog regulates the proliferation, differentiation, and migration of enteric neural crest cells in gut

TitleSonic hedgehog regulates the proliferation, differentiation, and migration of enteric neural crest cells in gut
Authors
KeywordsEnteric nervous system
Glial cell-line derived neurotrophic factor
Neural plexuses
Neurogenesis
Sonic hedgehog
Issue Date2004
PublisherRockefeller University Press. The Journal's web site is located at http://www.jcb.org
Citation
Journal Of Cell Biology, 2004, v. 166 n. 5, p. 673-684 How to Cite?
AbstractEnteric neural crest cells (NCCs) migrate and colonize the entire gut and proliferate and differentiate into neurons and glia of the enteric nervous system in vertebrate embryos. We have investigated the mitogenic and morphogenic functions of Sonic hedgehog (Shh) on enteric NCCs in cell and organ culture. Enteric NCCs expressed Shh receptor Patched and transcripts encoding the Shh signal transducer (Gli1). Shh promoted the proliferation and inhibited the differentiation of NCCs. The pro-neurogenic effect of glial cell line-derived neurotrophic factor (GDNF) on NCCs was abolished by Shh. In gut explants, NCCs migrated from the explants onto the adjacent substratum if GDNF was added, whereas addition of Shh abolished this migration. Neuronal differentiation and coalescence of neural crest-derived cells into myenteric plexuses in explants was repressed by the addition of Shh. Our data suggest that Shh controls the proliferation and differentiation of NCCs and modulates the responsiveness of NCCs toward GDNF inductions.
Persistent Identifierhttp://hdl.handle.net/10722/42619
ISSN
2015 Impact Factor: 8.717
2015 SCImago Journal Rankings: 7.923
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFu, Men_HK
dc.contributor.authorLui, VCHen_HK
dc.contributor.authorSham, MHen_HK
dc.contributor.authorPachnis, Ven_HK
dc.contributor.authorTam, PKHen_HK
dc.date.accessioned2007-03-23T04:28:00Z-
dc.date.available2007-03-23T04:28:00Z-
dc.date.issued2004en_HK
dc.identifier.citationJournal Of Cell Biology, 2004, v. 166 n. 5, p. 673-684en_HK
dc.identifier.issn0021-9525en_HK
dc.identifier.urihttp://hdl.handle.net/10722/42619-
dc.description.abstractEnteric neural crest cells (NCCs) migrate and colonize the entire gut and proliferate and differentiate into neurons and glia of the enteric nervous system in vertebrate embryos. We have investigated the mitogenic and morphogenic functions of Sonic hedgehog (Shh) on enteric NCCs in cell and organ culture. Enteric NCCs expressed Shh receptor Patched and transcripts encoding the Shh signal transducer (Gli1). Shh promoted the proliferation and inhibited the differentiation of NCCs. The pro-neurogenic effect of glial cell line-derived neurotrophic factor (GDNF) on NCCs was abolished by Shh. In gut explants, NCCs migrated from the explants onto the adjacent substratum if GDNF was added, whereas addition of Shh abolished this migration. Neuronal differentiation and coalescence of neural crest-derived cells into myenteric plexuses in explants was repressed by the addition of Shh. Our data suggest that Shh controls the proliferation and differentiation of NCCs and modulates the responsiveness of NCCs toward GDNF inductions.en_HK
dc.languageengen_HK
dc.publisherRockefeller University Press. The Journal's web site is located at http://www.jcb.orgen_HK
dc.relation.ispartofJournal of Cell Biologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectEnteric nervous systemen_HK
dc.subjectGlial cell-line derived neurotrophic factoren_HK
dc.subjectNeural plexusesen_HK
dc.subjectNeurogenesisen_HK
dc.subjectSonic hedgehogen_HK
dc.subject.meshEnteric nervous system - cytology - embryology - metabolismen_HK
dc.subject.meshGastrointestinal tract - cytology - embryology - innervationen_HK
dc.subject.meshNeural crest - cytology - embryology - metabolismen_HK
dc.subject.meshNeurons - cytology - drug effects - metabolismen_HK
dc.subject.meshTrans-activators - genetics - metabolism - pharmacologyen_HK
dc.titleSonic hedgehog regulates the proliferation, differentiation, and migration of enteric neural crest cells in guten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9525&volume=166&issue=5&spage=673&epage=684&date=2004&atitle=Sonic+hedgehog+regulates+the+proliferation,+differentiation,+and+migration+of+enteric+neural+crest+cells+in+guten_HK
dc.identifier.emailLui, VCH: vchlui@hkucc.hku.hken_HK
dc.identifier.emailSham, MH: mhsham@hkucc.hku.hken_HK
dc.identifier.emailTam, PKH: paultam@hkucc.hku.hken_HK
dc.identifier.authorityLui, VCH=rp00363en_HK
dc.identifier.authoritySham, MH=rp00380en_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1083/jcb.200401077en_HK
dc.identifier.pmid15337776-
dc.identifier.pmcidPMC2172437-
dc.identifier.scopuseid_2-s2.0-4444312892en_HK
dc.identifier.hkuros91497-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4444312892&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume166en_HK
dc.identifier.issue5en_HK
dc.identifier.spage673en_HK
dc.identifier.epage684en_HK
dc.identifier.isiWOS:000223708100008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridFu, M=49761323800en_HK
dc.identifier.scopusauthoridLui, VCH=7004231344en_HK
dc.identifier.scopusauthoridSham, MH=7003729109en_HK
dc.identifier.scopusauthoridPachnis, V=7003446290en_HK
dc.identifier.scopusauthoridTam, PKH=7202539421en_HK

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