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Article: Cystic fibrosis: Progress in mapping the disease locus using polymorphic DNA markers. I.

TitleCystic fibrosis: Progress in mapping the disease locus using polymorphic DNA markers. I.
Authors
KeywordsBiology
Genetics biology
Cytology and histology
Issue Date1985
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/CGR
Citation
Cytogenetics And Cell Genetics, 1985, v. 39 n. 4, p. 299-301 How to Cite?
AbstractThe conventional approach to the identification of the affected gene in inherited diseases is through the demonstration of specific biochemical abnormalities in patients, their tissues, or cells. This approach has, unfortunately, been unsuccessful in the case of cystic fibrosis (CF), the most common severe autosomal recessive disorder in Causasians. An alternative approach is to locate the CF gene by linkage studies with chromosomal markers. We report here our results of testing 39 DNA restriction fragment length polymorphic (RFLP) markers using a panel of 45 two-generation Canadian families each with two or more affected children. The probability of linkage between each marker and CF was analyzed by the lod score method using the LIPED program. The results of these analyses show that none of the markers tested is closely linked to the disease locus.
Persistent Identifierhttp://hdl.handle.net/10722/42527
ISSN
2003 Impact Factor: 1.162
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorZsiga, Men_HK
dc.contributor.authorKennedy, Den_HK
dc.date.accessioned2007-01-29T08:52:13Z-
dc.date.available2007-01-29T08:52:13Z-
dc.date.issued1985en_HK
dc.identifier.citationCytogenetics And Cell Genetics, 1985, v. 39 n. 4, p. 299-301en_HK
dc.identifier.issn0301-0171en_HK
dc.identifier.urihttp://hdl.handle.net/10722/42527-
dc.description.abstractThe conventional approach to the identification of the affected gene in inherited diseases is through the demonstration of specific biochemical abnormalities in patients, their tissues, or cells. This approach has, unfortunately, been unsuccessful in the case of cystic fibrosis (CF), the most common severe autosomal recessive disorder in Causasians. An alternative approach is to locate the CF gene by linkage studies with chromosomal markers. We report here our results of testing 39 DNA restriction fragment length polymorphic (RFLP) markers using a panel of 45 two-generation Canadian families each with two or more affected children. The probability of linkage between each marker and CF was analyzed by the lod score method using the LIPED program. The results of these analyses show that none of the markers tested is closely linked to the disease locus.en_HK
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dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/msword-
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/CGRen_HK
dc.relation.ispartofCytogenetics and Cell Geneticsen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectBiologyen_HK
dc.subjectGenetics biologyen_HK
dc.subjectCytology and histologyen_HK
dc.titleCystic fibrosis: Progress in mapping the disease locus using polymorphic DNA markers. I.en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0301-0171&volume=39&spage=299&epage=301&date=1985&atitle=Cystic+fibrosis:+progress+in+mapping+the+disease+locus+using+polymorphic+DNA+markers.+I.en_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1159/000132162-
dc.identifier.pmid3863749-
dc.identifier.scopuseid_2-s2.0-0022352151en_HK
dc.identifier.volume39en_HK
dc.identifier.issue4en_HK
dc.identifier.spage299en_HK
dc.identifier.epage301en_HK
dc.identifier.isiWOS:A1985ATK8400012-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridZsiga, M=7801563333en_HK
dc.identifier.scopusauthoridKennedy, D=7403112289en_HK

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