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Article: Ontogeny of 2-[ 125I]iodomelatonin binding sites in the chicken (Gallus domesticus) kidney and spleen

TitleOntogeny of 2-[ 125I]iodomelatonin binding sites in the chicken (Gallus domesticus) kidney and spleen
Authors
KeywordsAge-related change
Development
Immune system
Melatonin receptor
Pineal gland
Renal system
Issue Date1995
PublisherN R C Research Press. The Journal's web site is located at http://pubs.nrc-cnrc.gc.ca/cgi-bin/rp/rp2_desc_e?cjpp
Citation
Canadian Journal Of Physiology And Pharmacology, 1995, v. 73 n. 6, p. 685-692 How to Cite?
AbstractTo understand the possible role of melatonin receptors in the development of renal and immune functions, age-related variations of 2-[ 125I]iodomelatonin binding sites in the chicken kidney and spleen were investigated by radioreceptor assay. Chickens at embryonic day 20, as well as 2 days, 9 days, 2 weeks, 6 weeks, 12 weeks, and 16 weeks after hatching, were kept under a 12 h light : 12 h dark photoperiod and killed at the middle of the light period. Binding sites for 2-[ 125I]iodomelatonin in membrane preparations of the chicken kidney and spleen were present on embryonic day 20. The maximum binding densities (B(max)) in the kidney increased to a peak between 9 days and 2 weeks of age, then progressively decreased. B(max) values of 2-[ 125I]iodomelatonin binding sites in the chicken spleen were lower than in the kidney. The peak density in the chicken spleen was recorded at day 2 after hatching and decreased significantly after 6 weeks of age. There were no significant differences in binding affinities (K(d)) in kidney and spleen of chicken in the different age groups studied. The unity of Hill coefficients of 2-[ 125I]iodomelatonin binding sites of the chicken kidney and spleen in all age groups tested suggested that only a single class of binding sites was present in these tissues during development. It is proposed that the developmental changes in 2-[ 125I]iodomelatonin binding sites in the chicken kidney and spleen may be pertinent to the development of diurnal rhythms of kidney functions and the post-pubertal decline in immune functions of the chicken.
Persistent Identifierhttp://hdl.handle.net/10722/42506
ISSN
2015 Impact Factor: 1.704
2015 SCImago Journal Rankings: 0.683
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSong, Yen_HK
dc.contributor.authorPoon, AMSen_HK
dc.contributor.authorBrown, GMen_HK
dc.contributor.authorPang, SFen_HK
dc.date.accessioned2007-01-29T08:51:22Z-
dc.date.available2007-01-29T08:51:22Z-
dc.date.issued1995en_HK
dc.identifier.citationCanadian Journal Of Physiology And Pharmacology, 1995, v. 73 n. 6, p. 685-692en_HK
dc.identifier.issn0008-4212en_HK
dc.identifier.urihttp://hdl.handle.net/10722/42506-
dc.description.abstractTo understand the possible role of melatonin receptors in the development of renal and immune functions, age-related variations of 2-[ 125I]iodomelatonin binding sites in the chicken kidney and spleen were investigated by radioreceptor assay. Chickens at embryonic day 20, as well as 2 days, 9 days, 2 weeks, 6 weeks, 12 weeks, and 16 weeks after hatching, were kept under a 12 h light : 12 h dark photoperiod and killed at the middle of the light period. Binding sites for 2-[ 125I]iodomelatonin in membrane preparations of the chicken kidney and spleen were present on embryonic day 20. The maximum binding densities (B(max)) in the kidney increased to a peak between 9 days and 2 weeks of age, then progressively decreased. B(max) values of 2-[ 125I]iodomelatonin binding sites in the chicken spleen were lower than in the kidney. The peak density in the chicken spleen was recorded at day 2 after hatching and decreased significantly after 6 weeks of age. There were no significant differences in binding affinities (K(d)) in kidney and spleen of chicken in the different age groups studied. The unity of Hill coefficients of 2-[ 125I]iodomelatonin binding sites of the chicken kidney and spleen in all age groups tested suggested that only a single class of binding sites was present in these tissues during development. It is proposed that the developmental changes in 2-[ 125I]iodomelatonin binding sites in the chicken kidney and spleen may be pertinent to the development of diurnal rhythms of kidney functions and the post-pubertal decline in immune functions of the chicken.en_HK
dc.format.extent1605830 bytes-
dc.format.extent25600 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/msword-
dc.languageengen_HK
dc.publisherN R C Research Press. The Journal's web site is located at http://pubs.nrc-cnrc.gc.ca/cgi-bin/rp/rp2_desc_e?cjppen_HK
dc.relation.ispartofCanadian Journal of Physiology and Pharmacologyen_HK
dc.rightsCanadian Journal of Physiology and Pharmacology. Copyright © N R C Research Press.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAge-related changeen_HK
dc.subjectDevelopmenten_HK
dc.subjectImmune systemen_HK
dc.subjectMelatonin receptoren_HK
dc.subjectPineal glanden_HK
dc.subjectRenal systemen_HK
dc.subject.meshDose-response relationship, drugen_HK
dc.subject.meshBinding sitesen_HK
dc.subject.meshKidney - metabolismen_HK
dc.subject.meshMelatonin - pharmacologyen_HK
dc.subject.meshSpleen - metabolismen_HK
dc.titleOntogeny of 2-[ 125I]iodomelatonin binding sites in the chicken (Gallus domesticus) kidney and spleenen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0008-4212&volume=73&issue=6&spage=685&epage=692&date=1995&atitle=Ontogeny+of+2-[125I]iodomelatonin+binding+sites+in+the+chicken+(Gallus+domesticus)+kidney+and+spleenen_HK
dc.identifier.emailPoon, AMS: amspoon@hkucc.hku.hken_HK
dc.identifier.authorityPoon, AMS=rp00354en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid7585338-
dc.identifier.scopuseid_2-s2.0-0028991693en_HK
dc.identifier.hkuros15378-
dc.identifier.volume73en_HK
dc.identifier.issue6en_HK
dc.identifier.spage685en_HK
dc.identifier.epage692en_HK
dc.identifier.isiWOS:A1995RQ31100002-
dc.publisher.placeCanadaen_HK
dc.identifier.scopusauthoridSong, Y=25960367300en_HK
dc.identifier.scopusauthoridPoon, AMS=7103068868en_HK
dc.identifier.scopusauthoridBrown, GM=35493704500en_HK
dc.identifier.scopusauthoridPang, SF=7402528719en_HK

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