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Article: Asthma, atopy and tuberculin responses in Chinese schoolchildren in Hong Kong

TitleAsthma, atopy and tuberculin responses in Chinese schoolchildren in Hong Kong
Authors
KeywordsAsthma
Atopy
Tuberculosis
Immunisation
Children
Issue Date2001
PublisherB M J Publishing Group. The Journal's web site is located at http://thorax.bmjjournals.com/
Citation
Thorax, 2001, v. 56 n. 10, p. 770-773 How to Cite?
Abstract[Headnote] Background-The prevalence rates of asthma and other atopic disorders have increased steadily in many developed countries over the past few decades. Recent epidemiological and animal studies have suggested that BCG vaccination might be beneficial in reducing the subsequent development of atopy. This study investigates the relationship between asthma, allergic symptoms, atopy, and tuberculin response in Chinese school-- children who received BCG vaccination at birth. Methods-A total of 3110 schoolchildren aged 10 years were recruited for the Hong Kong arm of the phase II International Study of Asthma and Allergies in Childhood. Of the 2599 children born in Hong Kong and vaccinated with BCG after birth, 2201 had tuberculin testing performed at a mean (SD) age of 8.4 (1.4) years. A random subsample of 980 children was also recruited for skin prick testing. [Headnote] Results-The prevalence rates of asthma ever, wheeze ever, current wheeze, current rhinoconjunctivitis, and current flexural eczema were not significantly different between tuberculin positive and negative subjects. The mean (SE) tuberculin response was 3.4 (0.2) mm in atopic subjects and 3.3 (0.2) nun in non-atopic subjects (difference not significant). Logistic regression analyses did not reveal any significant relationship between asthma ever, current wheeze, atopy, and positive tuberculin responses. Conclusions-This study did not find any relationship between asthma, allergic symptoms, atopy, and positive tuberculin reactivity in Chinese schoolchildren vaccinated with BCG at birth.
Persistent Identifierhttp://hdl.handle.net/10722/42419
ISSN
2015 Impact Factor: 8.121
2015 SCImago Journal Rankings: 3.650
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, Gen_HK
dc.contributor.authorHui, DSCen_HK
dc.contributor.authorTam, CMen_HK
dc.contributor.authorChan, HHen_HK
dc.contributor.authorFok, TFen_HK
dc.contributor.authorChan, MMWen_HK
dc.contributor.authorLai, CKWen_HK
dc.date.accessioned2007-01-29T08:49:31Z-
dc.date.available2007-01-29T08:49:31Z-
dc.date.issued2001en_HK
dc.identifier.citationThorax, 2001, v. 56 n. 10, p. 770-773en_HK
dc.identifier.issn0040-6376en_HK
dc.identifier.urihttp://hdl.handle.net/10722/42419-
dc.description.abstract[Headnote] Background-The prevalence rates of asthma and other atopic disorders have increased steadily in many developed countries over the past few decades. Recent epidemiological and animal studies have suggested that BCG vaccination might be beneficial in reducing the subsequent development of atopy. This study investigates the relationship between asthma, allergic symptoms, atopy, and tuberculin response in Chinese school-- children who received BCG vaccination at birth. Methods-A total of 3110 schoolchildren aged 10 years were recruited for the Hong Kong arm of the phase II International Study of Asthma and Allergies in Childhood. Of the 2599 children born in Hong Kong and vaccinated with BCG after birth, 2201 had tuberculin testing performed at a mean (SD) age of 8.4 (1.4) years. A random subsample of 980 children was also recruited for skin prick testing. [Headnote] Results-The prevalence rates of asthma ever, wheeze ever, current wheeze, current rhinoconjunctivitis, and current flexural eczema were not significantly different between tuberculin positive and negative subjects. The mean (SE) tuberculin response was 3.4 (0.2) mm in atopic subjects and 3.3 (0.2) nun in non-atopic subjects (difference not significant). Logistic regression analyses did not reveal any significant relationship between asthma ever, current wheeze, atopy, and positive tuberculin responses. Conclusions-This study did not find any relationship between asthma, allergic symptoms, atopy, and positive tuberculin reactivity in Chinese schoolchildren vaccinated with BCG at birth.en_HK
dc.format.extent496674 bytes-
dc.format.extent25600 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/msword-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://thorax.bmjjournals.com/en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsThorax. Copyright © B M J Publishing Group.en_HK
dc.subjectAsthmaen_HK
dc.subjectAtopyen_HK
dc.subjectTuberculosisen_HK
dc.subjectImmunisationen_HK
dc.subjectChildrenen_HK
dc.titleAsthma, atopy and tuberculin responses in Chinese schoolchildren in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0040-6376&volume=56&issue=10&spage=770&epage=773&date=2001&atitle=Asthma,+atopy+and+tuberculin+responses+in+Chinese+schoolchildren+in+Hong+Kongen_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1136/thorax.56.10.770-
dc.identifier.pmid11562515-
dc.identifier.pmcidPMC1745922-
dc.identifier.scopuseid_2-s2.0-0034805631-
dc.identifier.hkuros72775-
dc.identifier.isiWOS:000171289100007-

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