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Article: Increase in plasma adrenomedullin in patients with heart failure characterised by diastolic dysfunction

TitleIncrease in plasma adrenomedullin in patients with heart failure characterised by diastolic dysfunction
Authors
KeywordsAdrenomedullin
Diastolic dysfunction
Doppler echocardiography
Heart failure
Issue Date2001
PublisherB M J Publishing Group. The Journal's web site is located at http://heart.bmjjournals.com/
Citation
Heart, 2001, v. 86 n. 2, p. 155-160 How to Cite?
AbstractObjective - To investigate the relation between plasma adrenomedullin and the severity of diastolic dysfunction in patients with heart failure. Design - Prospective study. Setting - University teaching hospital. Patients - 77 patients (mean (SEM) age 66.3 (1.2) years; 75% male) who were being followed in the outpatient clinic after admission to hospital for acute heart failure. Interventions - Same day echocardiography with Doppler studies; determination of venous adrenomedullin concentration by radioimmunoassay. Main outcome measures - Plasma adrenomedullin concentration and its correlation with systolic and diastolic function. Results - 31 patients (40%) had isolated diastolic dysfunction (ejection fraction > 50%), and the remaining 46 had a depressed ejection fraction (< 50%). Of the patients with diastolic dysfunction, 17 had a restrictive filling pattern. In all but one of these there was coexisting systolic failure (X 2 = 10.7, p = 0.001). Patients with systolic heart failure and a restrictive filling pattern (group 1, n = 16) had a higher plasma adrenomedullin than those with systolic failure and a non-restrictive filling pattern (group 2, n = 30) or with isolated diastolic heart failure and a nonrestrictive filling pattern (group 3, n = 30) (mean (SEM): 91.7 (21.1) v 38.4 (8.8) v 34.0 (6.5) pmol/1, both p < 0.05). All heart failure values were higher (p < 0.01) than the control value (6.9 (1.2) pmol/1). Ejection fraction and left ventricular dimensions were similar in groups 1 and 2. Plasma adrenomedullin did not correlate with ejection fraction or New York Heart Association functional class. Stepwise multiple regression analysis showed that the presence of a restrictive filling pattern was the only independent variable associated with a high plasma adrenomedullin. Conclusions - Plasma adrenomedullin concentrations in patients with heart failure are determined by the presence of diastolic dysfunction, and are especially raised in the presence of a restrictive filling pattern. There appears to be no correlation with systolic dysfunction.
Persistent Identifierhttp://hdl.handle.net/10722/42416
ISSN
2015 Impact Factor: 5.693
2015 SCImago Journal Rankings: 2.647
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYu, CMen_HK
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorLeung, Ren_HK
dc.contributor.authorWang, Qen_HK
dc.contributor.authorLai, WHen_HK
dc.contributor.authorLau, CPen_HK
dc.date.accessioned2007-01-29T08:49:27Z-
dc.date.available2007-01-29T08:49:27Z-
dc.date.issued2001en_HK
dc.identifier.citationHeart, 2001, v. 86 n. 2, p. 155-160en_HK
dc.identifier.issn1355-6037en_HK
dc.identifier.urihttp://hdl.handle.net/10722/42416-
dc.description.abstractObjective - To investigate the relation between plasma adrenomedullin and the severity of diastolic dysfunction in patients with heart failure. Design - Prospective study. Setting - University teaching hospital. Patients - 77 patients (mean (SEM) age 66.3 (1.2) years; 75% male) who were being followed in the outpatient clinic after admission to hospital for acute heart failure. Interventions - Same day echocardiography with Doppler studies; determination of venous adrenomedullin concentration by radioimmunoassay. Main outcome measures - Plasma adrenomedullin concentration and its correlation with systolic and diastolic function. Results - 31 patients (40%) had isolated diastolic dysfunction (ejection fraction > 50%), and the remaining 46 had a depressed ejection fraction (< 50%). Of the patients with diastolic dysfunction, 17 had a restrictive filling pattern. In all but one of these there was coexisting systolic failure (X 2 = 10.7, p = 0.001). Patients with systolic heart failure and a restrictive filling pattern (group 1, n = 16) had a higher plasma adrenomedullin than those with systolic failure and a non-restrictive filling pattern (group 2, n = 30) or with isolated diastolic heart failure and a nonrestrictive filling pattern (group 3, n = 30) (mean (SEM): 91.7 (21.1) v 38.4 (8.8) v 34.0 (6.5) pmol/1, both p < 0.05). All heart failure values were higher (p < 0.01) than the control value (6.9 (1.2) pmol/1). Ejection fraction and left ventricular dimensions were similar in groups 1 and 2. Plasma adrenomedullin did not correlate with ejection fraction or New York Heart Association functional class. Stepwise multiple regression analysis showed that the presence of a restrictive filling pattern was the only independent variable associated with a high plasma adrenomedullin. Conclusions - Plasma adrenomedullin concentrations in patients with heart failure are determined by the presence of diastolic dysfunction, and are especially raised in the presence of a restrictive filling pattern. There appears to be no correlation with systolic dysfunction.en_HK
dc.format.extent160512 bytes-
dc.format.extent25600 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/msword-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://heart.bmjjournals.com/en_HK
dc.relation.ispartofHearten_HK
dc.rightsHeart. Copyright © B M J Publishing Group.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAdrenomedullinen_HK
dc.subjectDiastolic dysfunctionen_HK
dc.subjectDoppler echocardiographyen_HK
dc.subjectHeart failureen_HK
dc.subject.meshCardiac output, low - blood - ultrasonographyen_HK
dc.subject.meshPeptides - blooden_HK
dc.subject.meshEchocardiographyen_HK
dc.subject.meshVentricular dysfunction, left - blooden_HK
dc.subject.meshBiological markers - blooden_HK
dc.titleIncrease in plasma adrenomedullin in patients with heart failure characterised by diastolic dysfunctionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1355-6037&volume=86&issue=2&spage=155&epage=160&date=2001&atitle=Increase+in+plasma+adrenomedullin+in+patients+with+heart+failure+characterised+by+diastolic+dysfunctionen_HK
dc.identifier.emailCheung, BMY:mycheung@hku.hken_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1136/heart.86.2.155en_HK
dc.identifier.pmid11454830-
dc.identifier.pmcidPMC1729865-
dc.identifier.scopuseid_2-s2.0-0034776015en_HK
dc.identifier.hkuros60540-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034776015&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume86en_HK
dc.identifier.issue2en_HK
dc.identifier.spage155en_HK
dc.identifier.epage160en_HK
dc.identifier.isiWOS:000170107600014-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYu, CM=7404976646en_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridLeung, R=7101876102en_HK
dc.identifier.scopusauthoridWang, Q=7406919551en_HK
dc.identifier.scopusauthoridLai, WH=18434390500en_HK
dc.identifier.scopusauthoridLau, CP=7401968501en_HK

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