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Article: Clinicopathological significance of p16 gene expression in the surgical treatment of head and neck squamous cell carcinomas

TitleClinicopathological significance of p16 gene expression in the surgical treatment of head and neck squamous cell carcinomas
Authors
Issue Date2002
PublisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/
Citation
Journal Of Clinical Pathology, 2002, v. 55 n. 1, p. 58-60 How to Cite?
AbstractAims: To evaluate the clinicopathological significance of p16 expression in the surgical management of squamous cell carcinomas of the oral cavity, oropharynx, hypopharynx, and larynx. Method: p16 expression in 225 head and neck squamous cell carcinomas (HNSCCs) was studied using an immunohistochemical method and paraffin wax embedded tumour tissues. Associations between p16 expression and clinicopathological features were investigated. Results: Decreased p16 expression was found in 48% of the tumours. There was a higher frequency of decreased p16 expression in tumours of the larynx compared with those from the pharynx and oral cavity. There was a significant correlation between decreased p16 expression and more advanced T stage. There was no significant correlation between p16 expression and sex, age, tumour grade, nodal metastasis, recurrence, or survival. Conclusion: There was a high frequency of downregulation of p16 expression in HNSCC. Tumours of the larynx had a significantly higher frequency of weak p16 expression compared with tumours of the oral cavity and pharynx. Downregulation of p16 contributed to cellular proliferation, resulting locally in a more advanced tumour. It had no prognostic significance for nodal metastasis and survival.
Persistent Identifierhttp://hdl.handle.net/10722/42313
ISSN
2015 Impact Factor: 2.912
2015 SCImago Journal Rankings: 1.260
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuen, PWen_HK
dc.contributor.authorMan, Men_HK
dc.contributor.authorLam, KYen_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2007-01-08T02:34:22Z-
dc.date.available2007-01-08T02:34:22Z-
dc.date.issued2002en_HK
dc.identifier.citationJournal Of Clinical Pathology, 2002, v. 55 n. 1, p. 58-60en_HK
dc.identifier.issn0021-9746en_HK
dc.identifier.urihttp://hdl.handle.net/10722/42313-
dc.description.abstractAims: To evaluate the clinicopathological significance of p16 expression in the surgical management of squamous cell carcinomas of the oral cavity, oropharynx, hypopharynx, and larynx. Method: p16 expression in 225 head and neck squamous cell carcinomas (HNSCCs) was studied using an immunohistochemical method and paraffin wax embedded tumour tissues. Associations between p16 expression and clinicopathological features were investigated. Results: Decreased p16 expression was found in 48% of the tumours. There was a higher frequency of decreased p16 expression in tumours of the larynx compared with those from the pharynx and oral cavity. There was a significant correlation between decreased p16 expression and more advanced T stage. There was no significant correlation between p16 expression and sex, age, tumour grade, nodal metastasis, recurrence, or survival. Conclusion: There was a high frequency of downregulation of p16 expression in HNSCC. Tumours of the larynx had a significantly higher frequency of weak p16 expression compared with tumours of the oral cavity and pharynx. Downregulation of p16 contributed to cellular proliferation, resulting locally in a more advanced tumour. It had no prognostic significance for nodal metastasis and survival.en_HK
dc.format.extent422280 bytes-
dc.format.extent2353 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/en_HK
dc.relation.ispartofJournal of Clinical Pathologyen_HK
dc.rightsJournal of Clinical Pathology. Copyright © B M J Publishing Group.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshCarcinoma, squamous cellen_HK
dc.subject.meshMetabolism - pathology - surgeryen_HK
dc.subject.meshHead and neck neoplasmsen_HK
dc.subject.meshCyclin-dependent kinase inhibitor p16en_HK
dc.subject.meshNeoplasm proteins - metabolismen_HK
dc.titleClinicopathological significance of p16 gene expression in the surgical treatment of head and neck squamous cell carcinomasen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9746&volume=55&issue=1&spage=58&epage=60&date=2002&atitle=Clinicopathological+significance+of+p16+gene+expression+in+the+surgical+treatment+of+head+and+neck+squamous+cell+carcinomasen_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid11825926-
dc.identifier.pmcidPMC1769568-
dc.identifier.scopuseid_2-s2.0-0036141797en_HK
dc.identifier.hkuros72142-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036141797&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume55en_HK
dc.identifier.issue1en_HK
dc.identifier.spage58en_HK
dc.identifier.epage60en_HK
dc.identifier.isiWOS:000173281300012-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYuen, PW=7103124007en_HK
dc.identifier.scopusauthoridMan, M=7007001514en_HK
dc.identifier.scopusauthoridLam, KY=7403657165en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK

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