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Article: Expression of IL-2R, IL-4R, IL-6R on peripheral blood lymphocytes in systemic lupus erythematosus and correlation with disease activity: A prospective study

TitleExpression of IL-2R, IL-4R, IL-6R on peripheral blood lymphocytes in systemic lupus erythematosus and correlation with disease activity: A prospective study
Authors
KeywordsCytokine receptors
Peripheral blood lymphocytes
Systemic lupus erythematosus
Issue Date1996
PublisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/
Citation
Journal Of Clinical Pathology, 1996, v. 49 n. 8, p. 660-663 How to Cite?
AbstractAims - To study the expression of interleukin-2 receptor (IL-2R), interleukin-4 receptor (IL-4R) and interleukin-6 receptor (IL-6R) on peripheral blood lymphocytes (PBL) in patients with systemic lupus erythematosus (SLE); to correlate the level of expression of these receptors with SLE disease activity, Methods - Peripheral blood lymphocytes were studied by a high sensitivity flow cytometry technique using monoclonal antibodies directed against CD25 (IL-2R α chain), CD122 (IL-2R β chain), CD124 (IL-4R), and CD126 (IL-6R). SLE disease activity was scored using the SLE Disease Activity Index, C3 and C4 concentrations, anti-dsDNA level, and absolute lymphocyte count. Results - Compared with normal controls, PBL from patients with SLE had a higher percentage of CD25+ cells (median 20.8% v 16.5%) and a lower percentage of CD122+ cells (median 13.1% v 22.4%). The difference in CD122+ cells was greater in the CD122(weak) population than the CD122(strong) (natural killer cell) population. The percentages of CD124+ and CD126+ PBLs in patients with SLE and controls were similar. On CD25+ cells, the relative antigenic level of the IL-2R α chain was significantly higher in patients with SLE (median 2.01 v 1.81). The relative antigenic levels of CD122+, CD124+ and CD126+ cells were similar in patients and controls. Neither the percentages nor the relative antigenic levels of all of these cytokine receptors were correlated with any of the parameters of disease activity. Conclusion - Lymphocyte activation in patients with SLE was evident from the increase in CD25 expression on PBL, with a reciprocal decrease in CD122 expression. As the expression of IL-2R, IL-4R, IL-6R did not correlate with disease activity, it seems that these cytokine/receptor systems do not play a direct role in disease activation in SLE.
Persistent Identifierhttp://hdl.handle.net/10722/42312
ISSN
2015 Impact Factor: 2.912
2015 SCImago Journal Rankings: 1.260
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, EYTen_HK
dc.contributor.authorLau, CSen_HK
dc.contributor.authorZola, Hen_HK
dc.date.accessioned2007-01-08T02:34:19Z-
dc.date.available2007-01-08T02:34:19Z-
dc.date.issued1996en_HK
dc.identifier.citationJournal Of Clinical Pathology, 1996, v. 49 n. 8, p. 660-663en_HK
dc.identifier.issn0021-9746en_HK
dc.identifier.urihttp://hdl.handle.net/10722/42312-
dc.description.abstractAims - To study the expression of interleukin-2 receptor (IL-2R), interleukin-4 receptor (IL-4R) and interleukin-6 receptor (IL-6R) on peripheral blood lymphocytes (PBL) in patients with systemic lupus erythematosus (SLE); to correlate the level of expression of these receptors with SLE disease activity, Methods - Peripheral blood lymphocytes were studied by a high sensitivity flow cytometry technique using monoclonal antibodies directed against CD25 (IL-2R α chain), CD122 (IL-2R β chain), CD124 (IL-4R), and CD126 (IL-6R). SLE disease activity was scored using the SLE Disease Activity Index, C3 and C4 concentrations, anti-dsDNA level, and absolute lymphocyte count. Results - Compared with normal controls, PBL from patients with SLE had a higher percentage of CD25+ cells (median 20.8% v 16.5%) and a lower percentage of CD122+ cells (median 13.1% v 22.4%). The difference in CD122+ cells was greater in the CD122(weak) population than the CD122(strong) (natural killer cell) population. The percentages of CD124+ and CD126+ PBLs in patients with SLE and controls were similar. On CD25+ cells, the relative antigenic level of the IL-2R α chain was significantly higher in patients with SLE (median 2.01 v 1.81). The relative antigenic levels of CD122+, CD124+ and CD126+ cells were similar in patients and controls. Neither the percentages nor the relative antigenic levels of all of these cytokine receptors were correlated with any of the parameters of disease activity. Conclusion - Lymphocyte activation in patients with SLE was evident from the increase in CD25 expression on PBL, with a reciprocal decrease in CD122 expression. As the expression of IL-2R, IL-4R, IL-6R did not correlate with disease activity, it seems that these cytokine/receptor systems do not play a direct role in disease activation in SLE.en_HK
dc.format.extent406460 bytes-
dc.format.extent110770 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/pdf-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/en_HK
dc.relation.ispartofJournal of Clinical Pathologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsJournal of Clinical Pathology. Copyright © B M J Publishing Group.en_HK
dc.subjectCytokine receptorsen_HK
dc.subjectPeripheral blood lymphocytesen_HK
dc.subjectSystemic lupus erythematosusen_HK
dc.subject.meshLupus erythematosus, systemic - blood - genetics - metabolismen_HK
dc.subject.meshLymphocytes - metabolismen_HK
dc.subject.meshReceptors, interleukin - blooden_HK
dc.subject.meshBiological markers - analysisen_HK
dc.subject.meshAntigens, cd - analysisen_HK
dc.titleExpression of IL-2R, IL-4R, IL-6R on peripheral blood lymphocytes in systemic lupus erythematosus and correlation with disease activity: A prospective studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9746&volume=49&issue=8&spage=660&epage=663&date=1996&atitle=Expression+of+IL-2R,+IL-4R,+IL-6R+on+peripheral+blood+lymphocytes+in+systemic+lupus+erythematosus+and+correlation+with+disease+activity:+a+prospective+studyen_HK
dc.identifier.emailLau, CS:cslau@hku.hken_HK
dc.identifier.authorityLau, CS=rp01348en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid8881918-
dc.identifier.pmcidPMC500611-
dc.identifier.scopuseid_2-s2.0-0029788923en_HK
dc.identifier.hkuros38147-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0029788923&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume49en_HK
dc.identifier.issue8en_HK
dc.identifier.spage660en_HK
dc.identifier.epage663en_HK
dc.identifier.isiWOS:A1996VB66000014-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChan, EYT=7401994013en_HK
dc.identifier.scopusauthoridLau, CS=14035682100en_HK
dc.identifier.scopusauthoridZola, H=7101742796en_HK

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