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Article: The prevalence and clinical characteristics of cystic fibrosis in South Asian Canadian immigrants

TitleThe prevalence and clinical characteristics of cystic fibrosis in South Asian Canadian immigrants
Authors
Issue Date2005
PublisherB M J Publishing Group. The Journal's web site is located at http://www.archdischild.com/
Citation
Archives Of Disease In Childhood, 2005, v. 90 n. 7, p. 675-679 How to Cite?
Abstract
Background: Cystic fibrosis (CF) is considered to be rare among individuals from the Indian subcontinent. Furthermore, affected individuals are reported to experience a more severe clinical course. Aims: It was hypothesised that CF is under diagnosed in people of South Asian origin and therefore the prevalence may be higher than previously estimated. Methods: The prevalence of CF in the South Asian and in the general population living in the same geographic region (Metropolitan Toronto) were compared between 1996 and 2001. Population data were obtained from the Canadian census survey. CF phenotype and genotype data were obtained from the Toronto CF database. Results: Among 381 patients with CF, 15 were of South Asian descent. The age related prevalence of CF among the South Asian and general populations was: 0-14 years, 1:9200 versus 1:6600; 15-24 years, 1:13 200 versus 1:7600; older than 25 years, 1:56 600 versus 1:12 400. Age at diagnosis, duration and severity of symptoms at diagnosis, current nutritional status, and FEV 1 were similar in the two groups. While not significant, FEV 1 tended to be lower (48% versus 57% predicted) among adult South Asians, compared to the general CF population. Also, the percentage with pancreatic sufficiency was higher (27% versus 16%) and the frequency of ΔF508 allele was lower (50% versus 65.1%). Conclusions: These data suggest that the prevalence and natural history of CF in South Asians is similar to that among individuals of European origin. The relatively lower prevalence among older South Asians may reflect an improving recognition of CF in this ethnic subgroup.
Persistent Identifierhttp://hdl.handle.net/10722/42311
ISSN
2013 Impact Factor: 2.905
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMeiZahav, Men_HK
dc.contributor.authorDurie, Pen_HK
dc.contributor.authorZielenski, Jen_HK
dc.contributor.authorSolomon, Men_HK
dc.contributor.authorTullis, Een_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorCorey, Men_HK
dc.date.accessioned2007-01-08T02:34:16Z-
dc.date.available2007-01-08T02:34:16Z-
dc.date.issued2005en_HK
dc.identifier.citationArchives Of Disease In Childhood, 2005, v. 90 n. 7, p. 675-679en_HK
dc.identifier.issn0003-9888en_HK
dc.identifier.urihttp://hdl.handle.net/10722/42311-
dc.description.abstractBackground: Cystic fibrosis (CF) is considered to be rare among individuals from the Indian subcontinent. Furthermore, affected individuals are reported to experience a more severe clinical course. Aims: It was hypothesised that CF is under diagnosed in people of South Asian origin and therefore the prevalence may be higher than previously estimated. Methods: The prevalence of CF in the South Asian and in the general population living in the same geographic region (Metropolitan Toronto) were compared between 1996 and 2001. Population data were obtained from the Canadian census survey. CF phenotype and genotype data were obtained from the Toronto CF database. Results: Among 381 patients with CF, 15 were of South Asian descent. The age related prevalence of CF among the South Asian and general populations was: 0-14 years, 1:9200 versus 1:6600; 15-24 years, 1:13 200 versus 1:7600; older than 25 years, 1:56 600 versus 1:12 400. Age at diagnosis, duration and severity of symptoms at diagnosis, current nutritional status, and FEV 1 were similar in the two groups. While not significant, FEV 1 tended to be lower (48% versus 57% predicted) among adult South Asians, compared to the general CF population. Also, the percentage with pancreatic sufficiency was higher (27% versus 16%) and the frequency of ΔF508 allele was lower (50% versus 65.1%). Conclusions: These data suggest that the prevalence and natural history of CF in South Asians is similar to that among individuals of European origin. The relatively lower prevalence among older South Asians may reflect an improving recognition of CF in this ethnic subgroup.en_HK
dc.format.extent87665 bytes-
dc.format.extent30208 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/msword-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://www.archdischild.com/en_HK
dc.relation.ispartofArchives of Disease in Childhooden_HK
dc.rightsArchives of disease in childhood. Copyright © B M J Publishing Group.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshMedical sciences - pediatricsen_HK
dc.subject.meshCystic fibrosisen_HK
dc.subject.meshDiagnosisen_HK
dc.subject.meshEthnicityen_HK
dc.subject.meshPrevalenceen_HK
dc.titleThe prevalence and clinical characteristics of cystic fibrosis in South Asian Canadian immigrantsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0003-9888&volume=90&issue=7&spage=675&epage=679&date=2005&atitle=The+prevalence+and+clinical+characteristics+of+cystic+fibrosis+in+South+Asian+Canadian+immigrantsen_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1136/adc.2003.042614en_HK
dc.identifier.pmid15970608en_HK
dc.identifier.pmcidPMC1720469-
dc.identifier.scopuseid_2-s2.0-21544438793en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-21544438793&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume90en_HK
dc.identifier.issue7en_HK
dc.identifier.spage675en_HK
dc.identifier.epage679en_HK
dc.identifier.isiWOS:000229950600008-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridMeiZahav, M=6603103045en_HK
dc.identifier.scopusauthoridDurie, P=7005360997en_HK
dc.identifier.scopusauthoridZielenski, J=7003732699en_HK
dc.identifier.scopusauthoridSolomon, M=7202021353en_HK
dc.identifier.scopusauthoridTullis, E=6602749234en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridCorey, M=7005819978en_HK

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