Article: The prevalence and clinical characteristics of cystic fibrosis in South Asian Canadian immigrants

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TitleThe prevalence and clinical characteristics of cystic fibrosis in South Asian Canadian immigrants
AuthorsMeiZahav, M2
Durie, P2
Zielenski, J2
Solomon, M2
Tullis, E1
Tsui, LC2
Corey, M2
Issue Date2005
PublisherB M J Publishing Group. The Journal's web site is located at http://www.archdischild.com/
CitationArchives Of Disease In Childhood, 2005, v. 90 n. 7, p. 675-679 [How to Cite?]
DOI: http://dx.doi.org/10.1136/adc.2003.042614
AbstractBackground: Cystic fibrosis (CF) is considered to be rare among individuals from the Indian subcontinent. Furthermore, affected individuals are reported to experience a more severe clinical course. Aims: It was hypothesised that CF is under diagnosed in people of South Asian origin and therefore the prevalence may be higher than previously estimated. Methods: The prevalence of CF in the South Asian and in the general population living in the same geographic region (Metropolitan Toronto) were compared between 1996 and 2001. Population data were obtained from the Canadian census survey. CF phenotype and genotype data were obtained from the Toronto CF database. Results: Among 381 patients with CF, 15 were of South Asian descent. The age related prevalence of CF among the South Asian and general populations was: 0-14 years, 1:9200 versus 1:6600; 15-24 years, 1:13 200 versus 1:7600; older than 25 years, 1:56 600 versus 1:12 400. Age at diagnosis, duration and severity of symptoms at diagnosis, current nutritional status, and FEV 1 were similar in the two groups. While not significant, FEV 1 tended to be lower (48% versus 57% predicted) among adult South Asians, compared to the general CF population. Also, the percentage with pancreatic sufficiency was higher (27% versus 16%) and the frequency of ΔF508 allele was lower (50% versus 65.1%). Conclusions: These data suggest that the prevalence and natural history of CF in South Asians is similar to that among individuals of European origin. The relatively lower prevalence among older South Asians may reflect an improving recognition of CF in this ethnic subgroup.
ISSN0003-9888
2011 Impact Factor: 2.881
2011 SCImago Journal Rankings: 0.199
DOIhttp://dx.doi.org/10.1136/adc.2003.042614
ISI Accession Number IDWOS:000229950600008
PubMed Central IDPMC1720469
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorMeiZahav, M
dc.contributor.authorDurie, P
dc.contributor.authorZielenski, J
dc.contributor.authorSolomon, M
dc.contributor.authorTullis, E
dc.contributor.authorTsui, LC
dc.contributor.authorCorey, M
dc.date.accessioned2007-01-08T02:34:16Z
dc.date.available2007-01-08T02:34:16Z
dc.date.issued2005
dc.description.abstractBackground: Cystic fibrosis (CF) is considered to be rare among individuals from the Indian subcontinent. Furthermore, affected individuals are reported to experience a more severe clinical course. Aims: It was hypothesised that CF is under diagnosed in people of South Asian origin and therefore the prevalence may be higher than previously estimated. Methods: The prevalence of CF in the South Asian and in the general population living in the same geographic region (Metropolitan Toronto) were compared between 1996 and 2001. Population data were obtained from the Canadian census survey. CF phenotype and genotype data were obtained from the Toronto CF database. Results: Among 381 patients with CF, 15 were of South Asian descent. The age related prevalence of CF among the South Asian and general populations was: 0-14 years, 1:9200 versus 1:6600; 15-24 years, 1:13 200 versus 1:7600; older than 25 years, 1:56 600 versus 1:12 400. Age at diagnosis, duration and severity of symptoms at diagnosis, current nutritional status, and FEV 1 were similar in the two groups. While not significant, FEV 1 tended to be lower (48% versus 57% predicted) among adult South Asians, compared to the general CF population. Also, the percentage with pancreatic sufficiency was higher (27% versus 16%) and the frequency of ΔF508 allele was lower (50% versus 65.1%). Conclusions: These data suggest that the prevalence and natural history of CF in South Asians is similar to that among individuals of European origin. The relatively lower prevalence among older South Asians may reflect an improving recognition of CF in this ethnic subgroup.
dc.description.naturepublished_or_final_version
dc.format.extent87665 bytes
dc.format.extent30208 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypeapplication/msword
dc.identifier.citationArchives Of Disease In Childhood, 2005, v. 90 n. 7, p. 675-679 [How to Cite?]
DOI: http://dx.doi.org/10.1136/adc.2003.042614
dc.identifier.doihttp://dx.doi.org/10.1136/adc.2003.042614
dc.identifier.epage679
dc.identifier.isiWOS:000229950600008
dc.identifier.issn0003-9888
2011 Impact Factor: 2.881
2011 SCImago Journal Rankings: 0.199
dc.identifier.issue7
dc.identifier.openurl
dc.identifier.pmcidPMC1720469
dc.identifier.pmid15970608
dc.identifier.scopuseid_2-s2.0-21544438793
dc.identifier.spage675
dc.identifier.urihttp://hdl.handle.net/10722/42311
dc.identifier.volume90
dc.languageeng
dc.publisherB M J Publishing Group. The Journal's web site is located at http://www.archdischild.com/
dc.publisher.placeUnited Kingdom
dc.relation.ispartofArchives of Disease in Childhood
dc.relation.referencesReferences in Scopus
dc.rightsArchives of disease in childhood. Copyright © B M J Publishing Group.
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.subject.meshMedical sciences - pediatrics
dc.subject.meshCystic fibrosis
dc.subject.meshDiagnosis
dc.subject.meshEthnicity
dc.subject.meshPrevalence
dc.titleThe prevalence and clinical characteristics of cystic fibrosis in South Asian Canadian immigrants
dc.typeArticle
Author Affiliations
  1. Saint Michael's Hospital, Toronto
  2. Hospital for Sick Children, Toronto