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Article: The prevalence and clinical characteristics of cystic fibrosis in South Asian Canadian immigrants
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TitleThe prevalence and clinical characteristics of cystic fibrosis in South Asian Canadian immigrants
 
AuthorsMeiZahav, M2
Durie, P2
Zielenski, J2
Solomon, M2
Tullis, E1
Tsui, LC2
Corey, M2
 
Issue Date2005
 
PublisherB M J Publishing Group. The Journal's web site is located at http://www.archdischild.com/
 
CitationArchives Of Disease In Childhood, 2005, v. 90 n. 7, p. 675-679 [How to Cite?]
DOI: http://dx.doi.org/10.1136/adc.2003.042614
 
AbstractBackground: Cystic fibrosis (CF) is considered to be rare among individuals from the Indian subcontinent. Furthermore, affected individuals are reported to experience a more severe clinical course. Aims: It was hypothesised that CF is under diagnosed in people of South Asian origin and therefore the prevalence may be higher than previously estimated. Methods: The prevalence of CF in the South Asian and in the general population living in the same geographic region (Metropolitan Toronto) were compared between 1996 and 2001. Population data were obtained from the Canadian census survey. CF phenotype and genotype data were obtained from the Toronto CF database. Results: Among 381 patients with CF, 15 were of South Asian descent. The age related prevalence of CF among the South Asian and general populations was: 0-14 years, 1:9200 versus 1:6600; 15-24 years, 1:13 200 versus 1:7600; older than 25 years, 1:56 600 versus 1:12 400. Age at diagnosis, duration and severity of symptoms at diagnosis, current nutritional status, and FEV 1 were similar in the two groups. While not significant, FEV 1 tended to be lower (48% versus 57% predicted) among adult South Asians, compared to the general CF population. Also, the percentage with pancreatic sufficiency was higher (27% versus 16%) and the frequency of ΔF508 allele was lower (50% versus 65.1%). Conclusions: These data suggest that the prevalence and natural history of CF in South Asians is similar to that among individuals of European origin. The relatively lower prevalence among older South Asians may reflect an improving recognition of CF in this ethnic subgroup.
 
ISSN0003-9888
2012 Impact Factor: 3.051
2012 SCImago Journal Rankings: 1.173
 
DOIhttp://dx.doi.org/10.1136/adc.2003.042614
 
PubMed Central IDPMC1720469
 
ISI Accession Number IDWOS:000229950600008
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorMeiZahav, M
 
dc.contributor.authorDurie, P
 
dc.contributor.authorZielenski, J
 
dc.contributor.authorSolomon, M
 
dc.contributor.authorTullis, E
 
dc.contributor.authorTsui, LC
 
dc.contributor.authorCorey, M
 
dc.date.accessioned2007-01-08T02:34:16Z
 
dc.date.available2007-01-08T02:34:16Z
 
dc.date.issued2005
 
dc.description.abstractBackground: Cystic fibrosis (CF) is considered to be rare among individuals from the Indian subcontinent. Furthermore, affected individuals are reported to experience a more severe clinical course. Aims: It was hypothesised that CF is under diagnosed in people of South Asian origin and therefore the prevalence may be higher than previously estimated. Methods: The prevalence of CF in the South Asian and in the general population living in the same geographic region (Metropolitan Toronto) were compared between 1996 and 2001. Population data were obtained from the Canadian census survey. CF phenotype and genotype data were obtained from the Toronto CF database. Results: Among 381 patients with CF, 15 were of South Asian descent. The age related prevalence of CF among the South Asian and general populations was: 0-14 years, 1:9200 versus 1:6600; 15-24 years, 1:13 200 versus 1:7600; older than 25 years, 1:56 600 versus 1:12 400. Age at diagnosis, duration and severity of symptoms at diagnosis, current nutritional status, and FEV 1 were similar in the two groups. While not significant, FEV 1 tended to be lower (48% versus 57% predicted) among adult South Asians, compared to the general CF population. Also, the percentage with pancreatic sufficiency was higher (27% versus 16%) and the frequency of ΔF508 allele was lower (50% versus 65.1%). Conclusions: These data suggest that the prevalence and natural history of CF in South Asians is similar to that among individuals of European origin. The relatively lower prevalence among older South Asians may reflect an improving recognition of CF in this ethnic subgroup.
 
dc.description.naturepublished_or_final_version
 
dc.format.extent87665 bytes
 
dc.format.extent30208 bytes
 
dc.format.mimetypeapplication/pdf
 
dc.format.mimetypeapplication/msword
 
dc.identifier.citationArchives Of Disease In Childhood, 2005, v. 90 n. 7, p. 675-679 [How to Cite?]
DOI: http://dx.doi.org/10.1136/adc.2003.042614
 
dc.identifier.doihttp://dx.doi.org/10.1136/adc.2003.042614
 
dc.identifier.epage679
 
dc.identifier.isiWOS:000229950600008
 
dc.identifier.issn0003-9888
2012 Impact Factor: 3.051
2012 SCImago Journal Rankings: 1.173
 
dc.identifier.issue7
 
dc.identifier.openurl
 
dc.identifier.pmcidPMC1720469
 
dc.identifier.pmid15970608
 
dc.identifier.scopuseid_2-s2.0-21544438793
 
dc.identifier.spage675
 
dc.identifier.urihttp://hdl.handle.net/10722/42311
 
dc.identifier.volume90
 
dc.languageeng
 
dc.publisherB M J Publishing Group. The Journal's web site is located at http://www.archdischild.com/
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofArchives of Disease in Childhood
 
dc.relation.referencesReferences in Scopus
 
dc.rightsArchives of disease in childhood. Copyright © B M J Publishing Group.
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshMedical sciences - pediatrics
 
dc.subject.meshCystic fibrosis
 
dc.subject.meshDiagnosis
 
dc.subject.meshEthnicity
 
dc.subject.meshPrevalence
 
dc.titleThe prevalence and clinical characteristics of cystic fibrosis in South Asian Canadian immigrants
 
dc.typeArticle
 
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Author Affiliations
  1. Saint Michael's Hospital University of Toronto
  2. Hospital for Sick Children University of Toronto