Article: Linkage of DNA probe B79a (D7S13) to cystic fibrosis

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TitleLinkage of DNA probe B79a (D7S13) to cystic fibrosis
AuthorsWainwright, BJ1
Tsui, LC1
Leppert, M1
Buchwald, M1
Estivill, X1
O'Connell, P1
Lathrop, M1
LaLouel, JM1
White, R1
Williamson, R1
Farrall, M1
Issue Date1987
PublisherCell Press. The Journal's web site is located at http://www.cell.com/AJHG/
CitationAmerican Journal Of Human Genetics, 1987, v. 41 n. 5, p. 944-947 [How to Cite?]
AbstractWe have conducted, in 64 affected families, a study of linkage between the anonymous DNA segment pB79a (D7S13) and the locus for cystic fibrosis (CF) on chromosome 7q. The maximum lod score was 12.60 at θ = .08 (confidence bounds .045-.135). Although D7S13 is not sufficiently close to CF for routine use in DNA-based prenatal diagnosis, it will be helpful in certain families when other nearby markers are uninformative. D7S13 will also be useful for refining the linkage map of the CF region.
ISSN0002-9297
2011 Impact Factor: 10.603
2011 SCImago Journal Rankings: 2.479
PubMed Central IDPMC1684343
DC Field
Value
dc.contributor.authorWainwright, BJ
dc.contributor.authorTsui, LC
dc.contributor.authorLeppert, M
dc.contributor.authorBuchwald, M
dc.contributor.authorEstivill, X
dc.contributor.authorO'Connell, P
dc.contributor.authorLathrop, M
dc.contributor.authorLaLouel, JM
dc.contributor.authorWhite, R
dc.contributor.authorWilliamson, R
dc.contributor.authorFarrall, M
dc.date.accessioned2007-01-08T02:33:44Z
dc.date.available2007-01-08T02:33:44Z
dc.date.issued1987
dc.description.abstractWe have conducted, in 64 affected families, a study of linkage between the anonymous DNA segment pB79a (D7S13) and the locus for cystic fibrosis (CF) on chromosome 7q. The maximum lod score was 12.60 at θ = .08 (confidence bounds .045-.135). Although D7S13 is not sufficiently close to CF for routine use in DNA-based prenatal diagnosis, it will be helpful in certain families when other nearby markers are uninformative. D7S13 will also be useful for refining the linkage map of the CF region.
dc.description.naturepublished_or_final_version
dc.format.extent512587 bytes
dc.format.extent30208 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypeapplication/msword
dc.identifier.citationAmerican Journal Of Human Genetics, 1987, v. 41 n. 5, p. 944-947 [How to Cite?]
dc.identifier.epage947
dc.identifier.issn0002-9297
2011 Impact Factor: 10.603
2011 SCImago Journal Rankings: 2.479
dc.identifier.issue5
dc.identifier.openurl
dc.identifier.pmcidPMC1684343
dc.identifier.pmid2890297
dc.identifier.scopuseid_2-s2.0-0023634434
dc.identifier.spage944
dc.identifier.urihttp://hdl.handle.net/10722/42287
dc.identifier.volume41
dc.languageeng
dc.publisherCell Press. The Journal's web site is located at http://www.cell.com/AJHG/
dc.publisher.placeUnited States
dc.relation.ispartofAmerican Journal of Human Genetics
dc.rightsAmerican journal of human genetics. Copyright © University of Chicago Press.
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.subject.meshLinkage (genetics)
dc.subject.meshGenetic markers
dc.subject.meshDna
dc.subject.meshCystic fibrosis
dc.subject.meshPolymorphism, restriction fragment length
dc.titleLinkage of DNA probe B79a (D7S13) to cystic fibrosis
dc.typeArticle
Author Affiliations
  1. Imperial College London