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Article: Linkage of DNA probe B79a (D7S13) to cystic fibrosis
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TitleLinkage of DNA probe B79a (D7S13) to cystic fibrosis
 
AuthorsWainwright, BJ1
Tsui, LC1
Leppert, M1
Buchwald, M1
Estivill, X1
O'Connell, P1
Lathrop, M1
LaLouel, JM1
White, R1
Williamson, R1
Farrall, M1
 
Issue Date1987
 
PublisherCell Press. The Journal's web site is located at http://www.cell.com/AJHG/
 
CitationAmerican Journal Of Human Genetics, 1987, v. 41 n. 5, p. 944-947 [How to Cite?]
 
AbstractWe have conducted, in 64 affected families, a study of linkage between the anonymous DNA segment pB79a (D7S13) and the locus for cystic fibrosis (CF) on chromosome 7q. The maximum lod score was 12.60 at θ = .08 (confidence bounds .045-.135). Although D7S13 is not sufficiently close to CF for routine use in DNA-based prenatal diagnosis, it will be helpful in certain families when other nearby markers are uninformative. D7S13 will also be useful for refining the linkage map of the CF region.
 
ISSN0002-9297
2013 Impact Factor: 10.987
 
PubMed Central IDPMC1684343
 
ISI Accession Number IDWOS:A1987K936100014
 
DC FieldValue
dc.contributor.authorWainwright, BJ
 
dc.contributor.authorTsui, LC
 
dc.contributor.authorLeppert, M
 
dc.contributor.authorBuchwald, M
 
dc.contributor.authorEstivill, X
 
dc.contributor.authorO'Connell, P
 
dc.contributor.authorLathrop, M
 
dc.contributor.authorLaLouel, JM
 
dc.contributor.authorWhite, R
 
dc.contributor.authorWilliamson, R
 
dc.contributor.authorFarrall, M
 
dc.date.accessioned2007-01-08T02:33:44Z
 
dc.date.available2007-01-08T02:33:44Z
 
dc.date.issued1987
 
dc.description.abstractWe have conducted, in 64 affected families, a study of linkage between the anonymous DNA segment pB79a (D7S13) and the locus for cystic fibrosis (CF) on chromosome 7q. The maximum lod score was 12.60 at θ = .08 (confidence bounds .045-.135). Although D7S13 is not sufficiently close to CF for routine use in DNA-based prenatal diagnosis, it will be helpful in certain families when other nearby markers are uninformative. D7S13 will also be useful for refining the linkage map of the CF region.
 
dc.description.naturepublished_or_final_version
 
dc.format.extent512587 bytes
 
dc.format.extent30208 bytes
 
dc.format.mimetypeapplication/pdf
 
dc.format.mimetypeapplication/msword
 
dc.identifier.citationAmerican Journal Of Human Genetics, 1987, v. 41 n. 5, p. 944-947 [How to Cite?]
 
dc.identifier.epage947
 
dc.identifier.isiWOS:A1987K936100014
 
dc.identifier.issn0002-9297
2013 Impact Factor: 10.987
 
dc.identifier.issue5
 
dc.identifier.openurl
 
dc.identifier.pmcidPMC1684343
 
dc.identifier.pmid2890297
 
dc.identifier.scopuseid_2-s2.0-0023634434
 
dc.identifier.spage944
 
dc.identifier.urihttp://hdl.handle.net/10722/42287
 
dc.identifier.volume41
 
dc.languageeng
 
dc.publisherCell Press. The Journal's web site is located at http://www.cell.com/AJHG/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofAmerican Journal of Human Genetics
 
dc.rightsAmerican journal of human genetics. Copyright © University of Chicago Press.
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshLinkage (genetics)
 
dc.subject.meshGenetic markers
 
dc.subject.meshDna
 
dc.subject.meshCystic fibrosis
 
dc.subject.meshPolymorphism, restriction fragment length
 
dc.titleLinkage of DNA probe B79a (D7S13) to cystic fibrosis
 
dc.typeArticle
 
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<contributor.author>Lathrop, M</contributor.author>
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Author Affiliations
  1. Imperial College London