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Article: Mapping of DNA markers linked to the cystic fibrosis locus on the long arm of chromosome 7
Title | Mapping of DNA markers linked to the cystic fibrosis locus on the long arm of chromosome 7 |
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Authors | |
Issue Date | 1987 |
Publisher | Cell Press. The Journal's web site is located at http://www.cell.com/AJHG/ |
Citation | American Journal Of Human Genetics, 1987, v. 40 n. 3, p. 228-236 How to Cite? |
Abstract | We have used a panel of eight human/mouse somatic-cell hybrids, each containing various portions of human chromosome 7, and three patient cell lines with interstitial deletions on chromosome 7 for localization of six DNA markers linked to the cystic fibrosis locus. Our data suggest that D7S15 is located in the region 7cen→q22, that MET is located in 7q22→31, and that D7S8 and 7C22 are located in q22→q32. The hybridization results for COL1A2 and TCRB are consistent with their previous assignment to 7q21→q22 and 7q32, respectively. Given the location of these six markers and their linkage relationships, it is probable that the cystic fibrosis locus is in either the distal region of band q22 or the proximal region of q31. Using the same set of cell lines, we have also examined the location of another chromosome 7 marker PGY1. The data show that PGY1 is located in the region 7cen→q22, a position very different from its previous assignment. |
Persistent Identifier | http://hdl.handle.net/10722/42285 |
ISSN | 2023 Impact Factor: 8.1 2023 SCImago Journal Rankings: 4.516 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zengerling, S | en_HK |
dc.contributor.author | Olek, K | en_HK |
dc.contributor.author | Tsui, LC | en_HK |
dc.date.accessioned | 2007-01-08T02:33:41Z | - |
dc.date.available | 2007-01-08T02:33:41Z | - |
dc.date.issued | 1987 | en_HK |
dc.identifier.citation | American Journal Of Human Genetics, 1987, v. 40 n. 3, p. 228-236 | en_HK |
dc.identifier.issn | 0002-9297 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/42285 | - |
dc.description.abstract | We have used a panel of eight human/mouse somatic-cell hybrids, each containing various portions of human chromosome 7, and three patient cell lines with interstitial deletions on chromosome 7 for localization of six DNA markers linked to the cystic fibrosis locus. Our data suggest that D7S15 is located in the region 7cen→q22, that MET is located in 7q22→31, and that D7S8 and 7C22 are located in q22→q32. The hybridization results for COL1A2 and TCRB are consistent with their previous assignment to 7q21→q22 and 7q32, respectively. Given the location of these six markers and their linkage relationships, it is probable that the cystic fibrosis locus is in either the distal region of band q22 or the proximal region of q31. Using the same set of cell lines, we have also examined the location of another chromosome 7 marker PGY1. The data show that PGY1 is located in the region 7cen→q22, a position very different from its previous assignment. | en_HK |
dc.format.extent | 2816754 bytes | - |
dc.format.extent | 30208 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.format.mimetype | application/msword | - |
dc.language | eng | en_HK |
dc.publisher | Cell Press. The Journal's web site is located at http://www.cell.com/AJHG/ | en_HK |
dc.relation.ispartof | American Journal of Human Genetics | en_HK |
dc.rights | American journal of human genetics. Copyright © University of Chicago Press. | en_HK |
dc.subject.mesh | Chromosome deletion | en_HK |
dc.subject.mesh | Dna - diagnostic use | en_HK |
dc.subject.mesh | Genetic markers | en_HK |
dc.subject.mesh | Hybrid cells - ultrastructure | en_HK |
dc.subject.mesh | Nucleic acid hybridization | en_HK |
dc.title | Mapping of DNA markers linked to the cystic fibrosis locus on the long arm of chromosome 7 | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-9297&volume=40&issue=3&spage=228&epage=236&date=1987&atitle=Mapping+of+DNA+markers+linked+to+the+cystic+fibrosis+locus+on+the+long+arm+of+chromosome+7 | en_HK |
dc.identifier.email | Tsui, LC: tsuilc@hkucc.hku.hk | en_HK |
dc.identifier.authority | Tsui, LC=rp00058 | en_HK |
dc.description.nature | published_or_final_version | en_HK |
dc.identifier.pmid | 3472464 | - |
dc.identifier.pmcid | PMC1684102 | - |
dc.identifier.scopus | eid_2-s2.0-0023272069 | en_HK |
dc.identifier.volume | 40 | en_HK |
dc.identifier.issue | 3 | en_HK |
dc.identifier.spage | 228 | en_HK |
dc.identifier.epage | 236 | en_HK |
dc.identifier.isi | WOS:A1987H085400003 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Zengerling, S=6507625753 | en_HK |
dc.identifier.scopusauthorid | Olek, K=16186574200 | en_HK |
dc.identifier.scopusauthorid | Tsui, LC=7102754167 | en_HK |
dc.identifier.issnl | 0002-9297 | - |