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Article: Mapping of DNA markers linked to the cystic fibrosis locus on the long arm of chromosome 7

TitleMapping of DNA markers linked to the cystic fibrosis locus on the long arm of chromosome 7
Authors
Issue Date1987
PublisherCell Press. The Journal's web site is located at http://www.cell.com/AJHG/
Citation
American Journal Of Human Genetics, 1987, v. 40 n. 3, p. 228-236 How to Cite?
AbstractWe have used a panel of eight human/mouse somatic-cell hybrids, each containing various portions of human chromosome 7, and three patient cell lines with interstitial deletions on chromosome 7 for localization of six DNA markers linked to the cystic fibrosis locus. Our data suggest that D7S15 is located in the region 7cen→q22, that MET is located in 7q22→31, and that D7S8 and 7C22 are located in q22→q32. The hybridization results for COL1A2 and TCRB are consistent with their previous assignment to 7q21→q22 and 7q32, respectively. Given the location of these six markers and their linkage relationships, it is probable that the cystic fibrosis locus is in either the distal region of band q22 or the proximal region of q31. Using the same set of cell lines, we have also examined the location of another chromosome 7 marker PGY1. The data show that PGY1 is located in the region 7cen→q22, a position very different from its previous assignment.
Persistent Identifierhttp://hdl.handle.net/10722/42285
ISSN
2015 Impact Factor: 10.794
2015 SCImago Journal Rankings: 8.769
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZengerling, Sen_HK
dc.contributor.authorOlek, Ken_HK
dc.contributor.authorTsui, LCen_HK
dc.date.accessioned2007-01-08T02:33:41Z-
dc.date.available2007-01-08T02:33:41Z-
dc.date.issued1987en_HK
dc.identifier.citationAmerican Journal Of Human Genetics, 1987, v. 40 n. 3, p. 228-236en_HK
dc.identifier.issn0002-9297en_HK
dc.identifier.urihttp://hdl.handle.net/10722/42285-
dc.description.abstractWe have used a panel of eight human/mouse somatic-cell hybrids, each containing various portions of human chromosome 7, and three patient cell lines with interstitial deletions on chromosome 7 for localization of six DNA markers linked to the cystic fibrosis locus. Our data suggest that D7S15 is located in the region 7cen→q22, that MET is located in 7q22→31, and that D7S8 and 7C22 are located in q22→q32. The hybridization results for COL1A2 and TCRB are consistent with their previous assignment to 7q21→q22 and 7q32, respectively. Given the location of these six markers and their linkage relationships, it is probable that the cystic fibrosis locus is in either the distal region of band q22 or the proximal region of q31. Using the same set of cell lines, we have also examined the location of another chromosome 7 marker PGY1. The data show that PGY1 is located in the region 7cen→q22, a position very different from its previous assignment.en_HK
dc.format.extent2816754 bytes-
dc.format.extent30208 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/msword-
dc.languageengen_HK
dc.publisherCell Press. The Journal's web site is located at http://www.cell.com/AJHG/en_HK
dc.relation.ispartofAmerican Journal of Human Geneticsen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsAmerican journal of human genetics. Copyright © University of Chicago Press.en_HK
dc.subject.meshChromosome deletionen_HK
dc.subject.meshDna - diagnostic useen_HK
dc.subject.meshGenetic markersen_HK
dc.subject.meshHybrid cells - ultrastructureen_HK
dc.subject.meshNucleic acid hybridizationen_HK
dc.titleMapping of DNA markers linked to the cystic fibrosis locus on the long arm of chromosome 7en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-9297&volume=40&issue=3&spage=228&epage=236&date=1987&atitle=Mapping+of+DNA+markers+linked+to+the+cystic+fibrosis+locus+on+the+long+arm+of+chromosome+7en_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid3472464-
dc.identifier.pmcidPMC1684102-
dc.identifier.scopuseid_2-s2.0-0023272069en_HK
dc.identifier.volume40en_HK
dc.identifier.issue3en_HK
dc.identifier.spage228en_HK
dc.identifier.epage236en_HK
dc.identifier.isiWOS:A1987H085400003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZengerling, S=6507625753en_HK
dc.identifier.scopusauthoridOlek, K=16186574200en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK

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