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Article: Genetic analysis of cystic fibrosis using linked DNA markers

TitleGenetic analysis of cystic fibrosis using linked DNA markers
Authors
Issue Date1986
PublisherCell Press. The Journal's web site is located at http://www.cell.com/AJHG/
Citation
American Journal Of Human Genetics, 1986, v. 39 n. 6, p. 720-728 How to Cite?
AbstractGenetic linkage has been analyzed between cystic fibrosis (CF) and a number of markers on the long arm of chromosome 7, including D7S15, COL1A2, PON, MET, D7S8, and TCRB, using a cohort of 47 Canadian and 13 Danish CF families. The analysis confirms the previous observations that both MET and D7S8 are closely linked to CF. Based on the result from one family, MET appears to be more proximal to the centromere than CF. Our analysis also suggests that genetic heterogeneity may occur for the high recombination fraction between CF and D7S8 observed in another family. In addition, a strong linkage disequilibrium has been observed between CF and the two closely flanking markers.
Persistent Identifierhttp://hdl.handle.net/10722/42284
ISSN
2015 Impact Factor: 10.794
2015 SCImago Journal Rankings: 8.769
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorBuetow, Ken_HK
dc.contributor.authorBuchwald, Men_HK
dc.date.accessioned2007-01-08T02:33:40Z-
dc.date.available2007-01-08T02:33:40Z-
dc.date.issued1986en_HK
dc.identifier.citationAmerican Journal Of Human Genetics, 1986, v. 39 n. 6, p. 720-728en_HK
dc.identifier.issn0002-9297en_HK
dc.identifier.urihttp://hdl.handle.net/10722/42284-
dc.description.abstractGenetic linkage has been analyzed between cystic fibrosis (CF) and a number of markers on the long arm of chromosome 7, including D7S15, COL1A2, PON, MET, D7S8, and TCRB, using a cohort of 47 Canadian and 13 Danish CF families. The analysis confirms the previous observations that both MET and D7S8 are closely linked to CF. Based on the result from one family, MET appears to be more proximal to the centromere than CF. Our analysis also suggests that genetic heterogeneity may occur for the high recombination fraction between CF and D7S8 observed in another family. In addition, a strong linkage disequilibrium has been observed between CF and the two closely flanking markers.en_HK
dc.format.extent1483016 bytes-
dc.format.extent30208 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/msword-
dc.languageengen_HK
dc.publisherCell Press. The Journal's web site is located at http://www.cell.com/AJHG/en_HK
dc.relation.ispartofAmerican Journal of Human Geneticsen_HK
dc.rightsAmerican journal of human genetics. Copyright © University of Chicago Press.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshChromosomes, human, pair 7en_HK
dc.subject.meshCystic fibrosis - geneticsen_HK
dc.subject.meshDna/geneticsen_HK
dc.subject.meshGenetic markersen_HK
dc.subject.meshLinkage (genetics)en_HK
dc.titleGenetic analysis of cystic fibrosis using linked DNA markersen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-9297&volume=39&issue=6&spage=720&epage=728&date=1986&atitle=Genetic+analysis+of+cystic+fibrosis+using+linked+DNA+markersen_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid3467587-
dc.identifier.pmcidPMC1684123-
dc.identifier.scopuseid_2-s2.0-0022894810en_HK
dc.identifier.volume39en_HK
dc.identifier.issue6en_HK
dc.identifier.spage720en_HK
dc.identifier.epage728en_HK
dc.identifier.isiWOS:A1986F541400006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridBuetow, K=7004956250en_HK
dc.identifier.scopusauthoridBuchwald, M=7006759922en_HK

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