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Article: Linkage of cystic fibrosis to two tightly linked DNA markers: joint report from a collaborative study

TitleLinkage of cystic fibrosis to two tightly linked DNA markers: joint report from a collaborative study
Authors
Issue Date1986
PublisherUniversity of Chicago Press. The Journal's web site is located at http://www.journals.uchicago.edu/AJHG
Citation
American journal of human genetics, 1986, v. 39 n. 6, p. 681-693 How to Cite?
AbstractA collaborative study involving seven research groups provided an opportunity to investigate the linkage relationships between cystic fibrosis and two DNA marker loci, MET and pJ3.11 (D7S8), on an extended sample of 211 tested families. The maximum lod scores, recombination estimates, and confidence upper bounds (in parentheses) were 91.0 at theta = .004 (.012) for CF and MET, 71.3 at theta = .003 (.011) for CF and D7S8, and 69.3 at theta = .018 (.036) for MET and D7S8. Three-locus analyses yielded best support for the order MET-CF-D7S8, with odds against the alternate orders CF-MET-D7S8 and CF-D7S8-MET of 9:1 and 161:1, respectively. However, the number of observed recombinants was small and only one of the recombinants was jointly informative for all three markers. Significant allelic association was found between CF and both MET and D7S8. Weaker association between the latter two loci is consistent with the order MET-CF-D7S8.
Persistent Identifierhttp://hdl.handle.net/10722/42283
ISSN
2015 Impact Factor: 10.794
2015 SCImago Journal Rankings: 8.769
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBeaudet, Aen_HK
dc.contributor.authorBowcock, Aen_HK
dc.contributor.authorBuchwald, Men_HK
dc.contributor.authorCavalli-Sforza, Len_HK
dc.contributor.authorFarrall, Men_HK
dc.contributor.authorKing, MCen_HK
dc.contributor.authorKlinger, Ken_HK
dc.contributor.authorLalouel, JMen_HK
dc.contributor.authorLathrop, Gen_HK
dc.contributor.authorNaylor, Sen_HK
dc.contributor.authorOtt, Jen_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorWainwright, Ben_HK
dc.contributor.authorWatkins, Pen_HK
dc.contributor.authorWhite, Ren_HK
dc.contributor.authorWilliamson, Ren_HK
dc.date.accessioned2007-01-08T02:33:38Z-
dc.date.available2007-01-08T02:33:38Z-
dc.date.issued1986en_HK
dc.identifier.citationAmerican journal of human genetics, 1986, v. 39 n. 6, p. 681-693en_HK
dc.identifier.issn0002-9297en_HK
dc.identifier.urihttp://hdl.handle.net/10722/42283-
dc.description.abstractA collaborative study involving seven research groups provided an opportunity to investigate the linkage relationships between cystic fibrosis and two DNA marker loci, MET and pJ3.11 (D7S8), on an extended sample of 211 tested families. The maximum lod scores, recombination estimates, and confidence upper bounds (in parentheses) were 91.0 at theta = .004 (.012) for CF and MET, 71.3 at theta = .003 (.011) for CF and D7S8, and 69.3 at theta = .018 (.036) for MET and D7S8. Three-locus analyses yielded best support for the order MET-CF-D7S8, with odds against the alternate orders CF-MET-D7S8 and CF-D7S8-MET of 9:1 and 161:1, respectively. However, the number of observed recombinants was small and only one of the recombinants was jointly informative for all three markers. Significant allelic association was found between CF and both MET and D7S8. Weaker association between the latter two loci is consistent with the order MET-CF-D7S8.en_HK
dc.format.extent2023167 bytes-
dc.format.extent30208 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/msword-
dc.languageengen_HK
dc.publisherUniversity of Chicago Press. The Journal's web site is located at http://www.journals.uchicago.edu/AJHGen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsAmerican journal of human genetics. Copyright © University of Chicago Press.en_HK
dc.subject.meshCystic fibrosis - geneticsen_HK
dc.subject.meshGenetic markersen_HK
dc.subject.meshLinkage (genetics)en_HK
dc.subject.meshHeterozygoteen_HK
dc.subject.meshDna restriction enzymesen_HK
dc.titleLinkage of cystic fibrosis to two tightly linked DNA markers: joint report from a collaborative studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-9297&volume=39&issue=6&spage=681&epage=693&date=1986&atitle=Linkage+of+cystic+fibrosis+to+two+tightly+linked+DNA+markers:+joint+report+from+a+collaborative+studyen_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid3026171-
dc.identifier.pmcidPMC1684135-
dc.identifier.scopuseid_2-s2.0-0022893783-
dc.identifier.isiWOS:A1986F541400001-

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