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Article: Ovarian surface epithelium: Family history and early events in ovarian cancer

TitleOvarian surface epithelium: Family history and early events in ovarian cancer
Authors
Issue Date2003
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.rbej.com/home
Citation
Reproductive Biology And Endocrinology, 2003, v. 1 How to Cite?
AbstractOvarian cancer is the most common cause of death from gynecological cancers in the Western world. There are many genetic and environmental factors which can influence a woman's risk of getting ovarian cancer. A strong family history of breast or ovarian cancer is definitely one of the most important and best-defined epidemiological risk factors. This review evaluates current knowledge of hereditary ovarian cancer. Histologic, cytologic and molecular studies on the ovarian surface epithelium (OSE), which is the origin of ovarian epithelial carcinomas, from women with a strong family history for ovarian carcinomas or with a mutation in one of the two known cancer susceptibility genes - BRCA1 and BRCA2, provide a background to facilitate understanding of the early changes in ovarian carcinogenesis. This overview is followed by a discussion of recent hypotheses and research on two questions. First, is there a mutational hotspot of BRCA mutation for ovarian cancer? Second, why do mutations in BRCA1 and BRCA2, which are ubiquitously expressed genes that participate in general cellular activities, lead preferentially to breast and ovarian cancer? © 2003 Wong and Auersperg; licensee BioMed Central Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/42266
ISSN
2015 Impact Factor: 2.147
2015 SCImago Journal Rankings: 0.919
PubMed Central ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, ASTen_HK
dc.contributor.authorAuersperg, Nen_HK
dc.date.accessioned2007-01-08T02:33:03Z-
dc.date.available2007-01-08T02:33:03Z-
dc.date.issued2003en_HK
dc.identifier.citationReproductive Biology And Endocrinology, 2003, v. 1en_HK
dc.identifier.issn1477-7827en_HK
dc.identifier.urihttp://hdl.handle.net/10722/42266-
dc.description.abstractOvarian cancer is the most common cause of death from gynecological cancers in the Western world. There are many genetic and environmental factors which can influence a woman's risk of getting ovarian cancer. A strong family history of breast or ovarian cancer is definitely one of the most important and best-defined epidemiological risk factors. This review evaluates current knowledge of hereditary ovarian cancer. Histologic, cytologic and molecular studies on the ovarian surface epithelium (OSE), which is the origin of ovarian epithelial carcinomas, from women with a strong family history for ovarian carcinomas or with a mutation in one of the two known cancer susceptibility genes - BRCA1 and BRCA2, provide a background to facilitate understanding of the early changes in ovarian carcinogenesis. This overview is followed by a discussion of recent hypotheses and research on two questions. First, is there a mutational hotspot of BRCA mutation for ovarian cancer? Second, why do mutations in BRCA1 and BRCA2, which are ubiquitously expressed genes that participate in general cellular activities, lead preferentially to breast and ovarian cancer? © 2003 Wong and Auersperg; licensee BioMed Central Ltd.en_HK
dc.format.extent223639 bytes-
dc.format.extent29696 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/msword-
dc.languageengen_HK
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.rbej.com/homeen_HK
dc.relation.ispartofReproductive Biology and Endocrinologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshBreast neoplasmsen_HK
dc.subject.meshCarcinomaen_HK
dc.subject.meshCell transformation, neoplasticen_HK
dc.subject.meshCells, cultureden_HK
dc.subject.meshEpithelial cellsen_HK
dc.titleOvarian surface epithelium: Family history and early events in ovarian canceren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1477-7827&volume=1&issue=1&spage=70&epage=&date=2003&atitle=Ovarian+surface+epithelium:+family+history+and+early+events+in+ovarian+canceren_HK
dc.identifier.emailWong, AST: awong1@hkucc.hku.hken_HK
dc.identifier.authorityWong, AST=rp00805en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1186/1477-7827-1-70en_HK
dc.identifier.pmid14609432-
dc.identifier.pmcidPMC270003-
dc.identifier.scopuseid_2-s2.0-4344586235en_HK
dc.identifier.hkuros91124-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4344586235&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume1en_HK
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWong, AST=23987963300en_HK
dc.identifier.scopusauthoridAuersperg, N=7006582556en_HK

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