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Article: Telomerase activity in pancreatic endocrine tumours: A potential marker for malignancy

TitleTelomerase activity in pancreatic endocrine tumours: A potential marker for malignancy
Authors
KeywordsPancreatic endocrine tumour
Telomerase
Issue Date2000
PublisherB M J Publishing Group. The Journal's web site is located at http://mp.bmjjournals.com/
Citation
Journal Of Clinical Pathology - Molecular Pathology, 2000, v. 53 n. 3, p. 133-136 How to Cite?
AbstractAims: Telomerase activation is known to be a common event in human cancer and may be a useful marker for malignancy. In general, the histological features of pancreatic endocrine tumours cannot be used to determine their malignant potential. The aim of this study was to investigate the role of testing telomerase activity in pancreatic endocrine tumours. Methods: Prospectively collected fresh frozen tissue specimens from 10 patients with pancreatic endocrine tumours (nine insulinomas, one adrenocorticotrophin producing pancreatic endocrine tumour) were examined by a highly sensitive polymerase chain reaction (PCR) based telomerase repeat protocol (TRAP). Results: Of the 10 pancreatic endocrine tumours, three had telomerase activity. The positive cases included two frankly malignant tumours with liver metastases and one pancreatic endocrine tumour occurring in the setting of multiple endocrine neoplasia type 1. The latter had an infiltrative border. Vascular and perineural tumour infiltration was noted. In the two malignant pancreatic endocrine tumours with liver metastases, telomerase activity was noted in the tumour and the adjacent morphologically non-neoplastic pancreas. Conclusion: To our knowledge, this is the first report of the role of telomerase activity in pancreatic endocrine tumours. Telomerase activity might be useful for distinguishing between benign and malignant pancreatic endocrine tumours.
Persistent Identifierhttp://hdl.handle.net/10722/42257
ISSN
2005 Impact Factor: 2.576
2005 SCImago Journal Rankings: 0.122
PubMed Central ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, KYen_HK
dc.contributor.authorLo, CYen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorLuk, JMen_HK
dc.date.accessioned2007-01-08T02:32:48Z-
dc.date.available2007-01-08T02:32:48Z-
dc.date.issued2000en_HK
dc.identifier.citationJournal Of Clinical Pathology - Molecular Pathology, 2000, v. 53 n. 3, p. 133-136en_HK
dc.identifier.issn1366-8714en_HK
dc.identifier.urihttp://hdl.handle.net/10722/42257-
dc.description.abstractAims: Telomerase activation is known to be a common event in human cancer and may be a useful marker for malignancy. In general, the histological features of pancreatic endocrine tumours cannot be used to determine their malignant potential. The aim of this study was to investigate the role of testing telomerase activity in pancreatic endocrine tumours. Methods: Prospectively collected fresh frozen tissue specimens from 10 patients with pancreatic endocrine tumours (nine insulinomas, one adrenocorticotrophin producing pancreatic endocrine tumour) were examined by a highly sensitive polymerase chain reaction (PCR) based telomerase repeat protocol (TRAP). Results: Of the 10 pancreatic endocrine tumours, three had telomerase activity. The positive cases included two frankly malignant tumours with liver metastases and one pancreatic endocrine tumour occurring in the setting of multiple endocrine neoplasia type 1. The latter had an infiltrative border. Vascular and perineural tumour infiltration was noted. In the two malignant pancreatic endocrine tumours with liver metastases, telomerase activity was noted in the tumour and the adjacent morphologically non-neoplastic pancreas. Conclusion: To our knowledge, this is the first report of the role of telomerase activity in pancreatic endocrine tumours. Telomerase activity might be useful for distinguishing between benign and malignant pancreatic endocrine tumours.en_HK
dc.format.extent91600 bytes-
dc.format.extent26112 bytes-
dc.format.extent128386 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/msword-
dc.format.mimetypeapplication/pdf-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://mp.bmjjournals.com/en_HK
dc.relation.ispartofJournal of Clinical Pathology - Molecular Pathologyen_HK
dc.rightsMolecular Pathology. Copyright © B M J Publishing Group.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectPancreatic endocrine tumouren_HK
dc.subjectTelomeraseen_HK
dc.subject.meshTelomerase - metabolismen_HK
dc.subject.meshPancreatic endocrine tumouren_HK
dc.subject.meshPancreatic neoplasms - enzymology - pathologyen_HK
dc.subject.meshMultiple endocrine neoplasia type 1 - enzymologyen_HK
dc.subject.meshInsulinoma - enzymology - pathology - secondaryen_HK
dc.titleTelomerase activity in pancreatic endocrine tumours: A potential marker for malignancyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1366-8714&volume=53&issue=3&spage=133&epage=136&date=2000&atitle=Telomerase+activity+in+pancreatic+endocrine+tumours:+a+potential+marker+for+malignancyen_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailLuk, JM: jmluk@hkucc.hku.hken_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityLuk, JM=rp00349en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1136/mp.53.3.133en_HK
dc.identifier.pmid10897332en_HK
dc.identifier.pmcidPMC1186919-
dc.identifier.scopuseid_2-s2.0-0034091371en_HK
dc.identifier.hkuros49730-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034091371&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume53en_HK
dc.identifier.issue3en_HK
dc.identifier.spage133en_HK
dc.identifier.epage136en_HK
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLam, KY=7403657165en_HK
dc.identifier.scopusauthoridLo, CY=55259176800en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridLuk, JM=7006777791en_HK

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