File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Sequence variations in EBNA-1 may dictate restriction of tissue distribution of Epstein-Barr virus in normal and tumour cells

TitleSequence variations in EBNA-1 may dictate restriction of tissue distribution of Epstein-Barr virus in normal and tumour cells
Authors
Issue Date1997
PublisherSociety for General Microbiology. The Journal's web site is located at http://vir.sgmjournals.org
Citation
Journal Of General Virology, 1997, v. 78 n. 7, p. 1663-1670 How to Cite?
AbstractIn seropositive individuals Epstein-Barr virus (EBV) establishes a virus reservoir in peripheral blood lymphocytes (PBLs). Transmission from one individual to another occurs via saliva due to a lytic (virion productive) phase of infection in the oropharynx. EBNA-1 is responsible for maintaining viral episomes in the host cell and could, therefore, also affect the persistence of the virus in different cell lineages. Based on sequence analysis of EBNA-1 we now demonstrate that (i) in addition to the prototype EBNA-1 (identical to the B95.8 virus EBNA-1), EBV in normal individuals encompasses multiple EBNA-1 subtypes, both in PBLs and in oral secretions; (ii) although EBV with prototype EBNA-1 is the predominant virus in normal individuals, it is very rarely associated with either nasopharyngeal carcinoma (NPC) or Burkitt's lymphoma (BL); (iii) EBV with an EBNA-1 subtype (V-val) frequently associated with NPC is also selectively detected in oral secretions and not in PBLs; (iv) EBV with the EBNA-1 subtype V-pro is restricted to PBLs, while a mutated version of this subtype is present in BL, but not in NPC. These findings suggest that the variations in EBNA-1 may be relevant to the ability of EBV to persist in different cell types, and hence relevant to its oncogenic potential.
Persistent Identifierhttp://hdl.handle.net/10722/42020
ISSN
2015 Impact Factor: 3.192
2015 SCImago Journal Rankings: 1.741
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGutiérrez, MIen_HK
dc.contributor.authorRaj, Aen_HK
dc.contributor.authorSpangler, Gen_HK
dc.contributor.authorSharma, Aen_HK
dc.contributor.authorHussain, Aen_HK
dc.contributor.authorJudde, JGen_HK
dc.contributor.authorTsao, SWen_HK
dc.contributor.authorYuen, PWen_HK
dc.contributor.authorJoab, Ien_HK
dc.contributor.authorMagrath, ITen_HK
dc.contributor.authorBhatia, Ken_HK
dc.date.accessioned2007-01-08T02:27:04Z-
dc.date.available2007-01-08T02:27:04Z-
dc.date.issued1997en_HK
dc.identifier.citationJournal Of General Virology, 1997, v. 78 n. 7, p. 1663-1670en_HK
dc.identifier.issn0022-1317en_HK
dc.identifier.urihttp://hdl.handle.net/10722/42020-
dc.description.abstractIn seropositive individuals Epstein-Barr virus (EBV) establishes a virus reservoir in peripheral blood lymphocytes (PBLs). Transmission from one individual to another occurs via saliva due to a lytic (virion productive) phase of infection in the oropharynx. EBNA-1 is responsible for maintaining viral episomes in the host cell and could, therefore, also affect the persistence of the virus in different cell lineages. Based on sequence analysis of EBNA-1 we now demonstrate that (i) in addition to the prototype EBNA-1 (identical to the B95.8 virus EBNA-1), EBV in normal individuals encompasses multiple EBNA-1 subtypes, both in PBLs and in oral secretions; (ii) although EBV with prototype EBNA-1 is the predominant virus in normal individuals, it is very rarely associated with either nasopharyngeal carcinoma (NPC) or Burkitt's lymphoma (BL); (iii) EBV with an EBNA-1 subtype (V-val) frequently associated with NPC is also selectively detected in oral secretions and not in PBLs; (iv) EBV with the EBNA-1 subtype V-pro is restricted to PBLs, while a mutated version of this subtype is present in BL, but not in NPC. These findings suggest that the variations in EBNA-1 may be relevant to the ability of EBV to persist in different cell types, and hence relevant to its oncogenic potential.en_HK
dc.format.extent378434 bytes-
dc.format.extent2252 bytes-
dc.format.extent2353 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherSociety for General Microbiology. The Journal's web site is located at http://vir.sgmjournals.orgen_HK
dc.relation.ispartofJournal of General Virologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshLymphocytes - cytology - virologyen_HK
dc.subject.meshEpstein-barr virus nuclear antigensen_HK
dc.subject.meshHerpesvirus 4, humanen_HK
dc.subject.meshVariation (genetics)en_HK
dc.subject.meshTumor cells, cultureden_HK
dc.titleSequence variations in EBNA-1 may dictate restriction of tissue distribution of Epstein-Barr virus in normal and tumour cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-1317&volume=78&issue=7&spage=1663&epage=1670&date=1997&atitle=Sequence+variations+in+EBNA-1+may+dictate+restriction+of+tissue+distribution+of+Epstein-Barr+virus+in+normal+and+tumour+cellsen_HK
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_HK
dc.identifier.authorityTsao, SW=rp00399en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid9225043-
dc.identifier.scopuseid_2-s2.0-1842289849en_HK
dc.identifier.hkuros29794-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1842289849&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume78en_HK
dc.identifier.issue7en_HK
dc.identifier.spage1663en_HK
dc.identifier.epage1670en_HK
dc.identifier.isiWOS:A1997XJ74700021-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridGutiérrez, MI=35447877900en_HK
dc.identifier.scopusauthoridRaj, A=8122281000en_HK
dc.identifier.scopusauthoridSpangler, G=7006495752en_HK
dc.identifier.scopusauthoridSharma, A=36240766500en_HK
dc.identifier.scopusauthoridHussain, A=16309554700en_HK
dc.identifier.scopusauthoridJudde, JG=6603699005en_HK
dc.identifier.scopusauthoridTsao, SW=7102813116en_HK
dc.identifier.scopusauthoridYuen, PW=7103124007en_HK
dc.identifier.scopusauthoridJoab, I=7004161068en_HK
dc.identifier.scopusauthoridMagrath, IT=7102518023en_HK
dc.identifier.scopusauthoridBhatia, K=7202401240en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats