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- Publisher Website: 10.3390/ijms17030300
- Scopus: eid_2-s2.0-84961239062
- PMID: 26999104
- WOS: WOS:000373712800127
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Article: Gut microbiota and nonalcoholic fatty liver disease: Insights on mechanism and application of metabolomics
| Title | Gut microbiota and nonalcoholic fatty liver disease: Insights on mechanism and application of metabolomics |
|---|---|
| Authors | |
| Keywords | Bile acids Choline Gut microbiota Insulin resistance NAFLD Obesity |
| Issue Date | 2016 |
| Citation | International Journal of Molecular Sciences, 2016, v. 17, n. 3, article no. 300 How to Cite? |
| Abstract | Gut microbiota are intricately involved in the development of obesity-related metabolic diseases such as nonalcoholic fatty liver disease (NAFLD), type 2 diabetes, and insulin resistance. In the current review, we discuss the role of gut microbiota in the development of NAFLD by focusing on the mechanisms of gut microbiota-mediated host energy metabolism, insulin resistance, regulation of bile acids and choline metabolism, as well as gut microbiota-targeted therapy. We also discuss the application of a metabolomic approach to characterize gut microbial metabotypes in NAFLD. |
| Persistent Identifier | http://hdl.handle.net/10722/342511 |
| ISSN | 2011 Impact Factor: 2.598 2020 SCImago Journal Rankings: 1.455 |
| ISI Accession Number ID |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | He, Xuyun | - |
| dc.contributor.author | Ji, Guang | - |
| dc.contributor.author | Jia, Wei | - |
| dc.contributor.author | Li, Houkai | - |
| dc.date.accessioned | 2024-04-17T07:04:20Z | - |
| dc.date.available | 2024-04-17T07:04:20Z | - |
| dc.date.issued | 2016 | - |
| dc.identifier.citation | International Journal of Molecular Sciences, 2016, v. 17, n. 3, article no. 300 | - |
| dc.identifier.issn | 1661-6596 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/342511 | - |
| dc.description.abstract | Gut microbiota are intricately involved in the development of obesity-related metabolic diseases such as nonalcoholic fatty liver disease (NAFLD), type 2 diabetes, and insulin resistance. In the current review, we discuss the role of gut microbiota in the development of NAFLD by focusing on the mechanisms of gut microbiota-mediated host energy metabolism, insulin resistance, regulation of bile acids and choline metabolism, as well as gut microbiota-targeted therapy. We also discuss the application of a metabolomic approach to characterize gut microbial metabotypes in NAFLD. | - |
| dc.language | eng | - |
| dc.relation.ispartof | International Journal of Molecular Sciences | - |
| dc.subject | Bile acids | - |
| dc.subject | Choline | - |
| dc.subject | Gut microbiota | - |
| dc.subject | Insulin resistance | - |
| dc.subject | NAFLD | - |
| dc.subject | Obesity | - |
| dc.title | Gut microbiota and nonalcoholic fatty liver disease: Insights on mechanism and application of metabolomics | - |
| dc.type | Article | - |
| dc.description.nature | link_to_subscribed_fulltext | - |
| dc.identifier.doi | 10.3390/ijms17030300 | - |
| dc.identifier.pmid | 26999104 | - |
| dc.identifier.scopus | eid_2-s2.0-84961239062 | - |
| dc.identifier.volume | 17 | - |
| dc.identifier.issue | 3 | - |
| dc.identifier.spage | article no. 300 | - |
| dc.identifier.epage | article no. 300 | - |
| dc.identifier.eissn | 1422-0067 | - |
| dc.identifier.isi | WOS:000373712800127 | - |