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- Publisher Website: 10.1126/science.1223813
- Scopus: eid_2-s2.0-84861978076
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Article: Host-gut microbiota metabolic interactions
| Title | Host-gut microbiota metabolic interactions |
|---|---|
| Authors | |
| Issue Date | 2012 |
| Citation | Science, 2012, v. 336, n. 6086, p. 1262-1267 How to Cite? |
| Abstract | The composition and activity of the gut microbiota codevelop with the host from birth and is subject to a complex interplay that depends on the host genome, nutrition, and life-style. The gut microbiota is involved in the regulation of multiple host metabolic pathways, giving rise to interactive host-microbiota metabolic, signaling, and immune-inflammatory axes that physiologically connect the gut, liver, muscle, and brain. A deeper understanding of these axes is a prerequisite for optimizing therapeutic strategies to manipulate the gut microbiota to combat disease and improve health. |
| Persistent Identifier | http://hdl.handle.net/10722/342414 |
| ISSN | 2021 Impact Factor: 63.714 2020 SCImago Journal Rankings: 12.556 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Nicholson, Jeremy K. | - |
| dc.contributor.author | Holmes, Elaine | - |
| dc.contributor.author | Kinross, James | - |
| dc.contributor.author | Burcelin, Remy | - |
| dc.contributor.author | Gibson, Glenn | - |
| dc.contributor.author | Jia, Wei | - |
| dc.contributor.author | Pettersson, Sven | - |
| dc.date.accessioned | 2024-04-17T07:03:38Z | - |
| dc.date.available | 2024-04-17T07:03:38Z | - |
| dc.date.issued | 2012 | - |
| dc.identifier.citation | Science, 2012, v. 336, n. 6086, p. 1262-1267 | - |
| dc.identifier.issn | 0036-8075 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/342414 | - |
| dc.description.abstract | The composition and activity of the gut microbiota codevelop with the host from birth and is subject to a complex interplay that depends on the host genome, nutrition, and life-style. The gut microbiota is involved in the regulation of multiple host metabolic pathways, giving rise to interactive host-microbiota metabolic, signaling, and immune-inflammatory axes that physiologically connect the gut, liver, muscle, and brain. A deeper understanding of these axes is a prerequisite for optimizing therapeutic strategies to manipulate the gut microbiota to combat disease and improve health. | - |
| dc.language | eng | - |
| dc.relation.ispartof | Science | - |
| dc.title | Host-gut microbiota metabolic interactions | - |
| dc.type | Article | - |
| dc.description.nature | link_to_subscribed_fulltext | - |
| dc.identifier.doi | 10.1126/science.1223813 | - |
| dc.identifier.scopus | eid_2-s2.0-84861978076 | - |
| dc.identifier.volume | 336 | - |
| dc.identifier.issue | 6086 | - |
| dc.identifier.spage | 1262 | - |
| dc.identifier.epage | 1267 | - |
| dc.identifier.eissn | 1095-9203 | - |