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- Publisher Website: 10.1016/j.ntt.2011.10.003
- Scopus: eid_2-s2.0-82655169242
- PMID: 22056924
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Article: Waterborne manganese exposure alters plasma, brain, and liver metabolites accompanied by changes in stereotypic behaviors
Title | Waterborne manganese exposure alters plasma, brain, and liver metabolites accompanied by changes in stereotypic behaviors |
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Authors | |
Keywords | Behavior Biomarker Circadian rhythm Manganese Metabolomics Neurotoxicity |
Issue Date | 2012 |
Citation | Neurotoxicology and Teratology, 2012, v. 34, n. 1, p. 27-36 How to Cite? |
Abstract | Overexposure to waterborne manganese (Mn) is linked with cognitive impairment in children and neurochemical abnormalities in other experimental models. In order to characterize the threshold between Mn-exposure and altered neurochemistry, it is important to identify biomarkers that positively correspond with brain Mn-accumulation. The objective of this study was to identify Mn-induced alterations in plasma, liver, and brain metabolites using liquid/gas chromatography-time of flight-mass spectrometry metabolomic analyses; and to monitor corresponding Mn-induced behavior changes. Weanling Sprague-Dawley rats had access to deionized drinking water either Mn-free or containing 1. g Mn/L for 6. weeks. Behaviors were monitored during the sixth week for a continuous 24. h period while in a home cage environment using video surveillance. Mn-exposure significantly increased liver, plasma, and brain Mn concentrations compared to control, specifically targeting the globus pallidus (GP). Mn significantly altered 98 metabolites in the brain, liver, and plasma; notably shifting cholesterol and fatty acid metabolism in the brain (increased oleic and palmitic acid; 12.57 and 15.48 fold change (FC), respectively), and liver (increased oleic acid, 14.51 FC; decreased hydroxybutyric acid, - 14.29 FC). Additionally, Mn-altered plasma metabolites homogentisic acid, chenodeoxycholic acid, and aspartic acid correlated significantly with GP and striatal Mn. Total distance traveled was significantly increased and positively correlated with Mn-exposure, while nocturnal stereotypic and exploratory behaviors were reduced with Mn-exposure and performed largely during the light cycle compared to unexposed rats. These data provide putative biomarkers for Mn-neurotoxicity and suggest that Mn disrupts the circadian cycle in rats. © 2011 Elsevier Inc. |
Persistent Identifier | http://hdl.handle.net/10722/342400 |
ISSN | 2021 Impact Factor: 4.071 2020 SCImago Journal Rankings: 0.947 |
DC Field | Value | Language |
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dc.contributor.author | Fordahl, Steve | - |
dc.contributor.author | Cooney, Paula | - |
dc.contributor.author | Qiu, Yunping | - |
dc.contributor.author | Xie, Guoxiang | - |
dc.contributor.author | Jia, Wei | - |
dc.contributor.author | Erikson, Keith M. | - |
dc.date.accessioned | 2024-04-17T07:03:33Z | - |
dc.date.available | 2024-04-17T07:03:33Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Neurotoxicology and Teratology, 2012, v. 34, n. 1, p. 27-36 | - |
dc.identifier.issn | 0892-0362 | - |
dc.identifier.uri | http://hdl.handle.net/10722/342400 | - |
dc.description.abstract | Overexposure to waterborne manganese (Mn) is linked with cognitive impairment in children and neurochemical abnormalities in other experimental models. In order to characterize the threshold between Mn-exposure and altered neurochemistry, it is important to identify biomarkers that positively correspond with brain Mn-accumulation. The objective of this study was to identify Mn-induced alterations in plasma, liver, and brain metabolites using liquid/gas chromatography-time of flight-mass spectrometry metabolomic analyses; and to monitor corresponding Mn-induced behavior changes. Weanling Sprague-Dawley rats had access to deionized drinking water either Mn-free or containing 1. g Mn/L for 6. weeks. Behaviors were monitored during the sixth week for a continuous 24. h period while in a home cage environment using video surveillance. Mn-exposure significantly increased liver, plasma, and brain Mn concentrations compared to control, specifically targeting the globus pallidus (GP). Mn significantly altered 98 metabolites in the brain, liver, and plasma; notably shifting cholesterol and fatty acid metabolism in the brain (increased oleic and palmitic acid; 12.57 and 15.48 fold change (FC), respectively), and liver (increased oleic acid, 14.51 FC; decreased hydroxybutyric acid, - 14.29 FC). Additionally, Mn-altered plasma metabolites homogentisic acid, chenodeoxycholic acid, and aspartic acid correlated significantly with GP and striatal Mn. Total distance traveled was significantly increased and positively correlated with Mn-exposure, while nocturnal stereotypic and exploratory behaviors were reduced with Mn-exposure and performed largely during the light cycle compared to unexposed rats. These data provide putative biomarkers for Mn-neurotoxicity and suggest that Mn disrupts the circadian cycle in rats. © 2011 Elsevier Inc. | - |
dc.language | eng | - |
dc.relation.ispartof | Neurotoxicology and Teratology | - |
dc.subject | Behavior | - |
dc.subject | Biomarker | - |
dc.subject | Circadian rhythm | - |
dc.subject | Manganese | - |
dc.subject | Metabolomics | - |
dc.subject | Neurotoxicity | - |
dc.title | Waterborne manganese exposure alters plasma, brain, and liver metabolites accompanied by changes in stereotypic behaviors | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.ntt.2011.10.003 | - |
dc.identifier.pmid | 22056924 | - |
dc.identifier.scopus | eid_2-s2.0-82655169242 | - |
dc.identifier.volume | 34 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 27 | - |
dc.identifier.epage | 36 | - |
dc.identifier.eissn | 1872-9738 | - |