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- Publisher Website: 10.1055/s-0028-1088332
- Scopus: eid_2-s2.0-64749100650
- PMID: 19003727
- WOS: WOS:000263032200002
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Article: Paeonol attenuates high-fat-diet-induced atherosclerosis in rabbits by anti-inflammatory activity
Title | Paeonol attenuates high-fat-diet-induced atherosclerosis in rabbits by anti-inflammatory activity |
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Authors | |
Keywords | Atherosclerosis Cortex Moutan NF-kB Paeonia suffruticosa Andrews (Ranunculaceae) Paeonol Proinflammatory cytokine |
Issue Date | 2009 |
Citation | Planta Medica, 2009, v. 75, n. 1, p. 7-11 How to Cite? |
Abstract | Cortex Moutan (Paeonia suffruticosa Andrews, Ranunculaceae) has several uses in traditional medicine, such as analgesic, antipyretic, and anti-inflammatory applications and use in the prevention of thromboembolic diseases. Paeonol, a main active component in Cortex Moutan, possesses various pharmacological activities, particularly an anti-atherosclerosis effect. However, so far there have been no reports evaluating the anti-inflammatory action of paeonol in atherosclerosis therapy. The purpose of this study was to investigate the association of the therapeutic effect of paeonol on atherosclerotic rabbits with its anti-inflammatory action. The atherosclerotic model was developed in 24 rabbits fed a high-fat diet for 12 weeks. Twelve rabbits on the high-fat diet then were administered with paeonol (p.o) for a subsequent 6 weeks at the doses of 75 mg/kg and 150 mg/kg. Histological analysis showed significant improvement in atherosclerosis plaque in the paeonol groups. Moreover, the blood levels of TNF-α, IL-1β, and CRP and the translocation of NF-κB to the nucleus were significantly suppressed in paeonol groups, as was the inhibition of lipid peroxidation. In conclusion, these findings suggest that the anti-inflammatory action of paeonol may contribute to its anti-atherosclerosis effect. © Georg Thieme Verlag KG Stuttgart. |
Persistent Identifier | http://hdl.handle.net/10722/342351 |
ISSN | 2021 Impact Factor: 3.007 2020 SCImago Journal Rankings: 0.422 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Li, Houkai | - |
dc.contributor.author | Dai, Min | - |
dc.contributor.author | Jia, Wei | - |
dc.date.accessioned | 2024-04-17T07:03:10Z | - |
dc.date.available | 2024-04-17T07:03:10Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Planta Medica, 2009, v. 75, n. 1, p. 7-11 | - |
dc.identifier.issn | 0032-0943 | - |
dc.identifier.uri | http://hdl.handle.net/10722/342351 | - |
dc.description.abstract | Cortex Moutan (Paeonia suffruticosa Andrews, Ranunculaceae) has several uses in traditional medicine, such as analgesic, antipyretic, and anti-inflammatory applications and use in the prevention of thromboembolic diseases. Paeonol, a main active component in Cortex Moutan, possesses various pharmacological activities, particularly an anti-atherosclerosis effect. However, so far there have been no reports evaluating the anti-inflammatory action of paeonol in atherosclerosis therapy. The purpose of this study was to investigate the association of the therapeutic effect of paeonol on atherosclerotic rabbits with its anti-inflammatory action. The atherosclerotic model was developed in 24 rabbits fed a high-fat diet for 12 weeks. Twelve rabbits on the high-fat diet then were administered with paeonol (p.o) for a subsequent 6 weeks at the doses of 75 mg/kg and 150 mg/kg. Histological analysis showed significant improvement in atherosclerosis plaque in the paeonol groups. Moreover, the blood levels of TNF-α, IL-1β, and CRP and the translocation of NF-κB to the nucleus were significantly suppressed in paeonol groups, as was the inhibition of lipid peroxidation. In conclusion, these findings suggest that the anti-inflammatory action of paeonol may contribute to its anti-atherosclerosis effect. © Georg Thieme Verlag KG Stuttgart. | - |
dc.language | eng | - |
dc.relation.ispartof | Planta Medica | - |
dc.subject | Atherosclerosis | - |
dc.subject | Cortex Moutan | - |
dc.subject | NF-kB | - |
dc.subject | Paeonia suffruticosa Andrews (Ranunculaceae) | - |
dc.subject | Paeonol | - |
dc.subject | Proinflammatory cytokine | - |
dc.title | Paeonol attenuates high-fat-diet-induced atherosclerosis in rabbits by anti-inflammatory activity | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1055/s-0028-1088332 | - |
dc.identifier.pmid | 19003727 | - |
dc.identifier.scopus | eid_2-s2.0-64749100650 | - |
dc.identifier.volume | 75 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 7 | - |
dc.identifier.epage | 11 | - |
dc.identifier.eissn | 1439-0221 | - |
dc.identifier.isi | WOS:000263032200002 | - |