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Article: Nanomolar cholera toxin inhibitors based on symmetrical pentavalent ganglioside GM1os-sym-corannulenes

TitleNanomolar cholera toxin inhibitors based on symmetrical pentavalent ganglioside GM1os-sym-corannulenes
Authors
Mattarella, MartinGarcia-Hartjes, JaimeWennekes, TomZuilhof, HanSiegel, Jay S.
Issue Date2013
Citation
Organic and Biomolecular Chemistry, 2013, v. 11, n. 26, p. 4333-4339 How to Cite?
DOI: http://dx.doi.org/10.1039/c3ob40438b
AbstractEight symmetric and pentavalent corannulene derivatives were functionalized with galactose and the ganglioside GM1-oligosaccharide (GM1os) via copper-catalyzed alkyne-azide cycloaddition (CuAAC) reactions. The compounds were evaluated for their ability to inhibit the binding of the pentavalent cholera toxin to its natural ligand, ganglioside GM1. In this assay, all ganglioside GM1os-sym-corannulenes proved to be highly potent nanomolar inhibitors of cholera toxin. © The Royal Society of Chemistry 2013.
Persistent Identifierhttp://hdl.handle.net/10722/341140
ISSN
1477-0520
2021 Impact Factor: 3.890
2020 SCImago Journal Rankings: 0.923
ISI Accession Number ID
WOS:000320330000010

 

DC FieldValueLanguage
dc.contributor.authorMattarella, Martin-
dc.contributor.authorGarcia-Hartjes, Jaime-
dc.contributor.authorWennekes, Tom-
dc.contributor.authorZuilhof, Han-
dc.contributor.authorSiegel, Jay S.-
dc.date.accessioned2024-03-13T08:40:28Z-
dc.date.available2024-03-13T08:40:28Z-
dc.date.issued2013-
dc.identifier.citationOrganic and Biomolecular Chemistry, 2013, v. 11, n. 26, p. 4333-4339-
dc.identifier.issn1477-0520-
dc.identifier.urihttp://hdl.handle.net/10722/341140-
dc.description.abstractEight symmetric and pentavalent corannulene derivatives were functionalized with galactose and the ganglioside GM1-oligosaccharide (GM1os) via copper-catalyzed alkyne-azide cycloaddition (CuAAC) reactions. The compounds were evaluated for their ability to inhibit the binding of the pentavalent cholera toxin to its natural ligand, ganglioside GM1. In this assay, all ganglioside GM1os-sym-corannulenes proved to be highly potent nanomolar inhibitors of cholera toxin. © The Royal Society of Chemistry 2013.-
dc.languageeng-
dc.relation.ispartofOrganic and Biomolecular Chemistry-
dc.titleNanomolar cholera toxin inhibitors based on symmetrical pentavalent ganglioside GM1os-sym-corannulenes-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/c3ob40438b-
dc.identifier.scopuseid_2-s2.0-84881033671-
dc.identifier.volume11-
dc.identifier.issue26-
dc.identifier.spage4333-
dc.identifier.epage4339-
dc.identifier.isiWOS:000320330000010-

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