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- Publisher Website: 10.1016/j.mce.2023.111990
- Scopus: eid_2-s2.0-85162090068
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Article: Role of omentin-1 in susceptibility to anxiety and depression like behaviors
Title | Role of omentin-1 in susceptibility to anxiety and depression like behaviors |
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Authors | |
Keywords | Blood-brain barrier Depression Microglial activation Omentin-1 |
Issue Date | 20-Aug-2023 |
Publisher | Elsevier |
Citation | Molecular and Cellular Endocrinology, 2023, v. 574 How to Cite? |
Abstract | Neuro-inflammation and blood-brain barrier (BBB) dysfunction are associated with depression. Evidence shows that adipokines enter the brain from the circulation, which regulates depressive behaviors. Omentin-1 is a newly identified adipocytokine that has anti-inflammatory effects, but little is known about its role in neuro-inflammation and mood-relevant behavior. Our results showed omentin-1 knockout mice (Omentin-1−/−) increased susceptibility to anxiety and depressive-like behaviors, which are associated with abnormalities of cerebral blood flow (CBF) and impaired BBB permeability. Moreover, omentin-1 depletion significantly increased hippocampal pro-inflammatory cytokines (IL-1β, TNFα, IL-6), caused microglial activation, inhibited hippocampus neurogenesis, and resulted in autophagy impairment by dysregulating ATG genes. Omentin-1 deficiency also sensitized mice to the behavioral changes induced by lipopolysaccharide (LPS), suggesting that omentin-1 could rescue neuro-inflammation by acting as an anti-depressant. Our in vitro microglia cell culture data confirmed that recombinant omentin-1 suppresses microglial activation and pro-inflammatory cytokine expression induced by LPS. Our study suggests that omentin-1 can be used as a promising therapeutic agent for the prevention or treatment of depression by providing a barrier-promoting effect and an endogenous anti-inflammatory balance to downregulate the proinflammatory cytokines. |
Persistent Identifier | http://hdl.handle.net/10722/338834 |
ISSN | 2021 Impact Factor: 4.369 2020 SCImago Journal Rankings: 1.296 |
DC Field | Value | Language |
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dc.contributor.author | Ji, L | - |
dc.contributor.author | Zhang, L | - |
dc.contributor.author | Liang, Z | - |
dc.contributor.author | Zhong, S | - |
dc.contributor.author | Liu, X | - |
dc.contributor.author | Liu, Z | - |
dc.contributor.author | Poon, WS | - |
dc.contributor.author | Song, Y | - |
dc.contributor.author | Chen, B | - |
dc.contributor.author | Wang, R | - |
dc.date.accessioned | 2024-03-11T10:31:54Z | - |
dc.date.available | 2024-03-11T10:31:54Z | - |
dc.date.issued | 2023-08-20 | - |
dc.identifier.citation | Molecular and Cellular Endocrinology, 2023, v. 574 | - |
dc.identifier.issn | 0303-7207 | - |
dc.identifier.uri | http://hdl.handle.net/10722/338834 | - |
dc.description.abstract | <p>Neuro-inflammation and blood-brain barrier (BBB) dysfunction are associated with depression. Evidence shows that adipokines enter the brain from the circulation, which regulates depressive behaviors. Omentin-1 is a newly identified adipocytokine that has anti-inflammatory effects, but little is known about its role in neuro-inflammation and mood-relevant behavior. Our results showed omentin-1 knockout mice (Omentin-1−/−) increased susceptibility to anxiety and depressive-like behaviors, which are associated with abnormalities of cerebral blood flow (CBF) and impaired BBB permeability. Moreover, omentin-1 depletion significantly increased hippocampal pro-inflammatory cytokines (IL-1β, TNFα, IL-6), caused microglial activation, inhibited hippocampus neurogenesis, and resulted in autophagy impairment by dysregulating ATG genes. Omentin-1 deficiency also sensitized mice to the behavioral changes induced by lipopolysaccharide (LPS), suggesting that omentin-1 could rescue neuro-inflammation by acting as an anti-depressant. Our in vitro microglia cell culture data confirmed that recombinant omentin-1 suppresses microglial activation and pro-inflammatory cytokine expression induced by LPS. Our study suggests that omentin-1 can be used as a promising therapeutic agent for the prevention or treatment of depression by providing a barrier-promoting effect and an endogenous anti-inflammatory balance to downregulate the proinflammatory cytokines.</p> | - |
dc.language | eng | - |
dc.publisher | Elsevier | - |
dc.relation.ispartof | Molecular and Cellular Endocrinology | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Blood-brain barrier | - |
dc.subject | Depression | - |
dc.subject | Microglial activation | - |
dc.subject | Omentin-1 | - |
dc.title | Role of omentin-1 in susceptibility to anxiety and depression like behaviors | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.mce.2023.111990 | - |
dc.identifier.scopus | eid_2-s2.0-85162090068 | - |
dc.identifier.volume | 574 | - |
dc.identifier.issnl | 0303-7207 | - |