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- Scopus: eid_2-s2.0-85151110127
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Article: Transcriptomic Profiling the Effects of Airway Exposure of Zinc Oxide and Silver Nanoparticles in Mouse Lungs
Title | Transcriptomic Profiling the Effects of Airway Exposure of Zinc Oxide and Silver Nanoparticles in Mouse Lungs |
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Authors | |
Keywords | animal model immune effects lung silver nanoparticles transcriptomics zinc oxide nanoparticles |
Issue Date | 8-Mar-2023 |
Publisher | MDPI |
Citation | International Journal of Molecular Sciences, 2023, v. 24, n. 6 How to Cite? |
Abstract | Consumers and manufacturers are exposed to nanosized zinc oxide (nZnO) and silver particles (nAg) via airways, but their biological effects are still not fully elucidated. To understand the immune effects, we exposed mice to 2, 10, or 50 μg of nZnO or nAg by oropharyngeal aspiration and analyzed the global gene expression profiles and immunopathological changes in the lungs after 1, 7, or 28 days. Our results show that the kinetics of responses varied in the lungs. Exposure to nZnO resulted in the highest accumulation of F4/80- and CD3-positive cells, and the largest number of differentially expressed genes (DEGs) were identified after day 1, while exposure to nAg caused peak responses at day 7. Additionally, nZnO mainly activated the innate immune responses leading to acute inflammation, whereas the nAg activated both innate and adaptive immune pathways, with long-lasting effects. This kinetic-profiling study provides an important data source to understand the cellular and molecular processes underlying nZnO- and nAg-induced transcriptomic changes, which lead to the characterization of the corresponding biological and toxicological effects of nZnO and nAg in the lungs. These findings could improve science-based hazard and risk assessment and the development of safe applications of engineered nanomaterials (ENMs), e.g., in biomedical applications. |
Persistent Identifier | http://hdl.handle.net/10722/337197 |
ISSN | 2011 Impact Factor: 2.598 2020 SCImago Journal Rankings: 1.455 |
DC Field | Value | Language |
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dc.contributor.author | Zhao, L | - |
dc.contributor.author | Wang, S | - |
dc.contributor.author | Ilves, M | - |
dc.contributor.author | Lehtonen, S | - |
dc.contributor.author | Saikko, L | - |
dc.contributor.author | El-Nezami, H | - |
dc.contributor.author | Alenius, H | - |
dc.contributor.author | Karisola, P | - |
dc.date.accessioned | 2024-03-11T10:18:50Z | - |
dc.date.available | 2024-03-11T10:18:50Z | - |
dc.date.issued | 2023-03-08 | - |
dc.identifier.citation | International Journal of Molecular Sciences, 2023, v. 24, n. 6 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | http://hdl.handle.net/10722/337197 | - |
dc.description.abstract | Consumers and manufacturers are exposed to nanosized zinc oxide (nZnO) and silver particles (nAg) via airways, but their biological effects are still not fully elucidated. To understand the immune effects, we exposed mice to 2, 10, or 50 μg of nZnO or nAg by oropharyngeal aspiration and analyzed the global gene expression profiles and immunopathological changes in the lungs after 1, 7, or 28 days. Our results show that the kinetics of responses varied in the lungs. Exposure to nZnO resulted in the highest accumulation of F4/80- and CD3-positive cells, and the largest number of differentially expressed genes (DEGs) were identified after day 1, while exposure to nAg caused peak responses at day 7. Additionally, nZnO mainly activated the innate immune responses leading to acute inflammation, whereas the nAg activated both innate and adaptive immune pathways, with long-lasting effects. This kinetic-profiling study provides an important data source to understand the cellular and molecular processes underlying nZnO- and nAg-induced transcriptomic changes, which lead to the characterization of the corresponding biological and toxicological effects of nZnO and nAg in the lungs. These findings could improve science-based hazard and risk assessment and the development of safe applications of engineered nanomaterials (ENMs), e.g., in biomedical applications. | - |
dc.language | eng | - |
dc.publisher | MDPI | - |
dc.relation.ispartof | International Journal of Molecular Sciences | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | animal model | - |
dc.subject | immune effects | - |
dc.subject | lung | - |
dc.subject | silver nanoparticles | - |
dc.subject | transcriptomics | - |
dc.subject | zinc oxide nanoparticles | - |
dc.title | Transcriptomic Profiling the Effects of Airway Exposure of Zinc Oxide and Silver Nanoparticles in Mouse Lungs | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/ijms24065183 | - |
dc.identifier.scopus | eid_2-s2.0-85151110127 | - |
dc.identifier.volume | 24 | - |
dc.identifier.issue | 6 | - |
dc.identifier.eissn | 1422-0067 | - |
dc.identifier.issnl | 1422-0067 | - |