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Article: Stages, scaffolds and strings in the spatial organisation of non-homologous end joining: Insights from X-ray diffraction and Cryo-EM

TitleStages, scaffolds and strings in the spatial organisation of non-homologous end joining: Insights from X-ray diffraction and Cryo-EM
Authors
Liang, ShikangChaplin, Amanda K.Stavridi, Antonia KefalaAppleby, RobertHnizda, AlesBlundell, Tom L.
KeywordsCryo-EM
DNA repair
Double-strand breaks
NHEJ
Scaffolds
Stages
Strings
X-ray diffraction
Issue Date2021
Citation
Progress in Biophysics and Molecular Biology, 2021, v. 163, p. 60-73 How to Cite?
DOI: http://dx.doi.org/10.1016/j.pbiomolbio.2020.11.008
AbstractNon-homologous end joining (NHEJ) is the preferred pathway for the repair of DNA double-strand breaks in humans. Here we describe three structural aspects of the repair pathway: stages, scaffolds and strings. We discuss the orchestration of DNA repair to guarantee robust and efficient NHEJ. We focus on structural studies over the past two decades, not only using X-ray diffraction, but also increasingly exploiting cryo-EM to investigate the macromolecular assemblies.
Persistent Identifierhttp://hdl.handle.net/10722/336258
ISSN
0079-6107
2021 Impact Factor: 4.799
2020 SCImago Journal Rankings: 0.859
ISI Accession Number ID
WOS:000658757700007

 

DC FieldValueLanguage
dc.contributor.authorLiang, Shikang-
dc.contributor.authorChaplin, Amanda K.-
dc.contributor.authorStavridi, Antonia Kefala-
dc.contributor.authorAppleby, Robert-
dc.contributor.authorHnizda, Ales-
dc.contributor.authorBlundell, Tom L.-
dc.date.accessioned2024-01-15T08:24:58Z-
dc.date.available2024-01-15T08:24:58Z-
dc.date.issued2021-
dc.identifier.citationProgress in Biophysics and Molecular Biology, 2021, v. 163, p. 60-73-
dc.identifier.issn0079-6107-
dc.identifier.urihttp://hdl.handle.net/10722/336258-
dc.description.abstractNon-homologous end joining (NHEJ) is the preferred pathway for the repair of DNA double-strand breaks in humans. Here we describe three structural aspects of the repair pathway: stages, scaffolds and strings. We discuss the orchestration of DNA repair to guarantee robust and efficient NHEJ. We focus on structural studies over the past two decades, not only using X-ray diffraction, but also increasingly exploiting cryo-EM to investigate the macromolecular assemblies.-
dc.languageeng-
dc.relation.ispartofProgress in Biophysics and Molecular Biology-
dc.subjectCryo-EM-
dc.subjectDNA repair-
dc.subjectDouble-strand breaks-
dc.subjectNHEJ-
dc.subjectScaffolds-
dc.subjectStages-
dc.subjectStrings-
dc.subjectX-ray diffraction-
dc.titleStages, scaffolds and strings in the spatial organisation of non-homologous end joining: Insights from X-ray diffraction and Cryo-EM-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.pbiomolbio.2020.11.008-
dc.identifier.pmid33285184-
dc.identifier.scopuseid_2-s2.0-85097877815-
dc.identifier.volume163-
dc.identifier.spage60-
dc.identifier.epage73-
dc.identifier.isiWOS:000658757700007-

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