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- Publisher Website: 10.1038/s41541-023-00621-1
- Scopus: eid_2-s2.0-85148738594
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Article: Impact of host genetic polymorphisms on response to inactivated influenza vaccine in children
| Title | Impact of host genetic polymorphisms on response to inactivated influenza vaccine in children |
|---|---|
| Authors | |
| Issue Date | 20-Feb-2023 |
| Publisher | Springer Nature in partnership with the Sealy Center for Vaccine Development |
| Citation | NPJ vaccines., 2023, v. 8, n. 1 How to Cite? |
| Abstract | In randomized controlled trials of influenza vaccination, 550 children received trivalent-inactivated influenza vaccine, permitting us to explore relationship between vaccine response and host single nucleotide polymorphisms (SNPs) in 23 candidate genes with adjustment of multiple testing. For host SNPs in TLR7-1817G/T (rs5741880), genotype GT was associated with lower odds (OR: 0.22, 95% CI: 0.09, 0.53) of have post-vaccination hemagglutination-inhibiting (HAI) titers >= 40, compared with genotype GG and TT combined under the over-dominant model. For host SNPs in TLR8-129G/C (rs3764879), genotype GT was associated with lower odds (OR: 0.47; 95% CI: 0.28, 0.80) of have post vaccination HAI titers >= 40 compared with genotype GG and AA combined under the over-dominant model. Our results could contribute to the development of better vaccines that may offer improved protection to all recipients. |
| Persistent Identifier | http://hdl.handle.net/10722/332052 |
| ISSN | 2021 Impact Factor: 9.399 2020 SCImago Journal Rankings: 2.691 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Tsang, Tim K | - |
| dc.contributor.author | Wang, Can | - |
| dc.contributor.author | Tsang, Nicole N Y | - |
| dc.contributor.author | Fang, Vicky J | - |
| dc.contributor.author | Perera, Ranawaka A P M | - |
| dc.contributor.author | Peiris, Malik J S | - |
| dc.contributor.author | Leung, Gabriel M | - |
| dc.contributor.author | Cowling, Benjamin J | - |
| dc.contributor.author | Ip, Dennis K M | - |
| dc.date.accessioned | 2023-09-28T05:00:31Z | - |
| dc.date.available | 2023-09-28T05:00:31Z | - |
| dc.date.issued | 2023-02-20 | - |
| dc.identifier.citation | NPJ vaccines., 2023, v. 8, n. 1 | - |
| dc.identifier.issn | 2059-0105 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/332052 | - |
| dc.description.abstract | <p>In randomized controlled trials of influenza vaccination, 550 children received trivalent-inactivated influenza vaccine, permitting us to explore relationship between vaccine response and host single nucleotide polymorphisms (SNPs) in 23 candidate genes with adjustment of multiple testing. For host SNPs in TLR7-1817G/T (rs5741880), genotype GT was associated with lower odds (OR: 0.22, 95% CI: 0.09, 0.53) of have post-vaccination hemagglutination-inhibiting (HAI) titers >= 40, compared with genotype GG and TT combined under the over-dominant model. For host SNPs in TLR8-129G/C (rs3764879), genotype GT was associated with lower odds (OR: 0.47; 95% CI: 0.28, 0.80) of have post vaccination HAI titers >= 40 compared with genotype GG and AA combined under the over-dominant model. Our results could contribute to the development of better vaccines that may offer improved protection to all recipients.<br></p> | - |
| dc.language | eng | - |
| dc.publisher | Springer Nature in partnership with the Sealy Center for Vaccine Development | - |
| dc.relation.ispartof | NPJ vaccines. | - |
| dc.title | Impact of host genetic polymorphisms on response to inactivated influenza vaccine in children | - |
| dc.type | Article | - |
| dc.identifier.doi | 10.1038/s41541-023-00621-1 | - |
| dc.identifier.scopus | eid_2-s2.0-85148738594 | - |
| dc.identifier.volume | 8 | - |
| dc.identifier.issue | 1 | - |
| dc.identifier.eissn | 2059-0105 | - |