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Article: Boosting the Sonodynamic Cancer Therapy Performance of 2D Layered Double Hydroxide Nanosheet-Based Sonosensitizers Via Crystalline-to-Amorphous Phase Transformation
Title | Boosting the Sonodynamic Cancer Therapy Performance of 2D Layered Double Hydroxide Nanosheet-Based Sonosensitizers Via Crystalline-to-Amorphous Phase Transformation |
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Authors | |
Keywords | 2D nanosheets layered double hydroxides phase transformation sonodynamic therapy sonosensitizers |
Issue Date | 2023 |
Citation | Advanced Materials, 2023, v. 35, n. 17, article no. 2209692 How to Cite? |
Abstract | Sonodynamic therapy (SDT) has been a promising therapeutic modality for cancer because of its superior advantages compared with other therapeutic strategies. However, the current sonosensitizers used for SDT normally exhibit low activity for ultrasound (US)-induced reactive oxygen species (ROS) generation. Herein, the crystalline-to-amorphous phase transformation is reported as a simple but powerful strategy to engineer ultrathin 2D CoW-LDH and NiW-LDH nanosheets as highly efficient sonosensitizers for SDT. The phase transformation of CoW-LDH and NiW-LDH nanosheets from polycrystalline to amorphous ones is achieved through a simple acid etching treatment. Importantly, compared with the polycrystalline one, the amorphous CoW-LDH (a-CoW-LDH) nanosheets possess higher ROS generation activity under US irradiation, which is ≈17 times of the commercial TiO2 sonosensitizer. The results suggest that the enhanced performance of ultrathin a-CoW-LDH nanosheets for US-induced ROS generation may be attributed to the phase transformation-induced defect generation and electronic structure changes. After polyethylene glycol modification, the a-CoW-LDH nanosheets can serve as a high-efficiency sonosensitizer for SDT to achieve cell death in vitro and tumor eradication in vivo under US irradiation. |
Persistent Identifier | http://hdl.handle.net/10722/330021 |
ISSN | 2021 Impact Factor: 32.086 2020 SCImago Journal Rankings: 10.707 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Hu, Tingting | - |
dc.contributor.author | Shen, Weicheng | - |
dc.contributor.author | Meng, Fanqi | - |
dc.contributor.author | Yang, Shuqing | - |
dc.contributor.author | Yu, Shilong | - |
dc.contributor.author | Li, Hai | - |
dc.contributor.author | Zhang, Qinghua | - |
dc.contributor.author | Gu, Lin | - |
dc.contributor.author | Tan, Chaoliang | - |
dc.contributor.author | Liang, Ruizheng | - |
dc.date.accessioned | 2023-08-09T03:37:14Z | - |
dc.date.available | 2023-08-09T03:37:14Z | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | Advanced Materials, 2023, v. 35, n. 17, article no. 2209692 | - |
dc.identifier.issn | 0935-9648 | - |
dc.identifier.uri | http://hdl.handle.net/10722/330021 | - |
dc.description.abstract | Sonodynamic therapy (SDT) has been a promising therapeutic modality for cancer because of its superior advantages compared with other therapeutic strategies. However, the current sonosensitizers used for SDT normally exhibit low activity for ultrasound (US)-induced reactive oxygen species (ROS) generation. Herein, the crystalline-to-amorphous phase transformation is reported as a simple but powerful strategy to engineer ultrathin 2D CoW-LDH and NiW-LDH nanosheets as highly efficient sonosensitizers for SDT. The phase transformation of CoW-LDH and NiW-LDH nanosheets from polycrystalline to amorphous ones is achieved through a simple acid etching treatment. Importantly, compared with the polycrystalline one, the amorphous CoW-LDH (a-CoW-LDH) nanosheets possess higher ROS generation activity under US irradiation, which is ≈17 times of the commercial TiO2 sonosensitizer. The results suggest that the enhanced performance of ultrathin a-CoW-LDH nanosheets for US-induced ROS generation may be attributed to the phase transformation-induced defect generation and electronic structure changes. After polyethylene glycol modification, the a-CoW-LDH nanosheets can serve as a high-efficiency sonosensitizer for SDT to achieve cell death in vitro and tumor eradication in vivo under US irradiation. | - |
dc.language | eng | - |
dc.relation.ispartof | Advanced Materials | - |
dc.subject | 2D nanosheets | - |
dc.subject | layered double hydroxides | - |
dc.subject | phase transformation | - |
dc.subject | sonodynamic therapy | - |
dc.subject | sonosensitizers | - |
dc.title | Boosting the Sonodynamic Cancer Therapy Performance of 2D Layered Double Hydroxide Nanosheet-Based Sonosensitizers Via Crystalline-to-Amorphous Phase Transformation | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/adma.202209692 | - |
dc.identifier.scopus | eid_2-s2.0-85150791738 | - |
dc.identifier.volume | 35 | - |
dc.identifier.issue | 17 | - |
dc.identifier.spage | article no. 2209692 | - |
dc.identifier.epage | article no. 2209692 | - |
dc.identifier.eissn | 1521-4095 | - |
dc.identifier.isi | WOS:000950553900001 | - |